Protein Alignment clumsy and grin2aa

DIOPT Version :9

• Sequence 1: NP_001036373.1
• Gene: clumsy / 35394
• FlyBaseID: FBgn0026255
• Length: 1002
• Species: Drosophila melanogaster
• Sequence 2: XP_021329529.1
• Gene: grin2aa / 563297
• ZFINID: ZDB-GENE-070424-129
• Length: 1460
• Species: Danio rerio
• Alignment Length: 1093
• Identity: 247/1093 - (22%)
• Similarity: 422/1093 - (38%)
• Gaps: 267/1093 - (24%)

  Fly    31 FTSDKDESEIAFRTAVDRANILERNVELVPIVVYANTDDSFIMEKMVCNLIS----QGVIAIFGP 91
            :.||:|     .|....:.:.::.||    :.:..|..|...:...||:|:|    .||  :||
Zfish    46 YISDRD-----IRALWSKDDPIDVNV----VTLLVNETDPKSIITHVCDLMSGTKIHGV--VFG- 98

  Fly    92 STGSSSDIIASICDTLD----IPHIVYDWIPNESIPDRE-HST---MTLNVHPDNLLLSQGLAEI 148
             .|:..:.||.|.|.:.    ||.:......:..:.|:: .||   ...::..:.||    :..|
Zfish    99 -DGTDQEAIAQILDFISSQTLIPILGIHGGSSMIMADKDVKSTFFQFGASIQQEALL----MLNI 158

  Fly   149 VQSFAWRSFTVVYETDKELQQLQDILQ-------VGEPISNPTTVKQLGPGDDHRPFLKEIKLST 206
            ::.:.|..|::|.......|....||:       ||..:.:..|:..: .||.....  ::|...
Zfish   159 MEEYDWHVFSIVTSKFPGYQDFIAILKTTVDNSFVGWDLQHIITLDAV-DGDSRTQI--QLKKVQ 220

  Fly   207 DNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHS------------------------ 247
            ...::|:|:.|....||::|..|.:.|......:|.|.|.:
Zfish   221 SPVVLLYCSKDEAAYILEEARSLGLTGFGYIWIVPSLTTGNPEITPDTFPSGMISVSYDDWDYPL 285

  Fly   248 -------------------IDFGELSGVEANITTVRLMD-----PSDFH--VKNVVHDWEEREKR 286
                               .:||::.  ||..:....|:     ||..|  :.||..|.::....
Zfish   286 EARVRDGLGIITTAAAAMLEEFGDIP--EAKTSCYGQMEKTKLPPSALHKYMMNVTWDGKDLSFT 348

  Fly   287 EGRYFKVDPNRVKSQMILLN-DAVWLFSKGLTELGIFE--ELTAPDLECRRKKP-WPFGKRIIEF 347
            |..| :|.|..|   :|:|| |..|      .::|.:|  .||.       |.| ||
Zfish   349 EDGY-QVHPKLV---VIVLNKDREW------EKMGKWENQSLTL-------KYPVWP-------- 388

  Fly   348 IKARSEETSTGRIDFNENGQRSFFTLRFMELNSDGFLDLATWDPVNGLDVLNDDEESEKRVGQKL 412
                         .||..|...         ..|..|.:.|.:....:.|    |..|:..|..:
Zfish   389 -------------RFNSFGDAE---------TDDNHLTIVTLEEKPFVIV----ENVERLTGTCM 427

  Fly   413 SNKTFIVSSRLGAPFLTLREPQEGEILTGNSRY-----EGYSIDLINEIAKMLNFKFEFRMSPDG 472
            .|.            :..|:..:.....|...|     :|:.||::.:||:.:.|.::..:..:|
Zfish   428 RNS------------VPCRKHIKDNTTEGGGTYIKKCCKGFCIDILKKIARNVKFTYDLYLVTNG 480

  Fly   473 KYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSKP--PTPP 535
            |:|  .|:...|:|:|.::::..|.:.:..||:...|.:.:||:.||:..|||::.|:.  ...|
Zfish   481 KHG--KKINNVWNGMVGEVVNKKAVMAVGSLTINEERSEVIDFSVPFVETGISVMVSRSNGTVSP 543

  Fly   536 TDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENPHPC---------KEPEEVENIW 591
            :   :||.|||..||:.|     |:.|||  :..||...:|...|.         |:|....  :
Zfish   544 S---AFLEPFSASVWVMM-----FVMLLL--VTAMAVFMFEYISPLGFNRNLAQGKDPHGPS--F 596

  Fly   592 SIMNTTWLSIGSLMGQGCDIL-PKAASTRLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINS 655
            ::....||..|.:......:. ||..:::.:..:|.|||::.|.|||||||||:......:.:..
Zfish   597 TMGKAVWLLWGLVFNNSVPVQNPKGTTSKFIVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTG 661

  Fly   656 AEDLAAQSKIKY------GAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTKTNDEGVE--- 711
            ..|...||...|      |.:..|||....|.:....:|.|            .|.:..||.
Zfish   662 LSDKKFQSPYSYSPPFRFGTVPNGSTERNIRKNYPDMHQYM------------VKYHQTGVNDAL 714

  Fly   712 -RVQKGKNLYAFLMESTTLEYNVERK--CDLVQIGGWLDYKS--YGIAMPFNSPYRKQISAAVLK 771
             .::.|| |.||:.::..|.|...|.  |.||.||....:.:  ||||:...|.:::.:..|:|.
Zfish   715 VSLKTGK-LDAFIYDAAVLNYMAGRDEGCKLVTIGSGYIFATTGYGIALQKGSLWKRPVDLAILA 778

  Fly   772 LGELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVGGVFLVLGLGLLSAMVLGCTEFL 836
            :...|::.||:.:|..     |.|. ::::...:.:|.::|:.|||.:|.    :||.|....|:
Zfish   779 IIGDGEMEELEAQWLT-----GICH-NEKNEVMSSQLDVDNMAGVFYMLA----TAMGLSLITFV 833

  Fly   837 WNVKSVAIEEKI---SLKEAFKSEA------LFAAR--IWITTKPVHTSSESGSSNSSSSSSSRS 890
            |        |.:   .|:..|....      ||:..  ||.....||...:..||:...|..|..
Zfish   834 W--------EHLFYWRLRYCFTGVCSGTPGLLFSISRGIWSCIHGVHIDMKKKSSDLDFSPQSNM 890

  Fly   891 KHSFKS--QGLSMKSLKSSGYQDVEAS---VHSKLKKIGSMFSLKSQKTVTPPPEIGWKLDKS-T 949
            ....||  |..:|.:|..|.....:..   :||....|..|.:.|.....|.        ::| .
Zfish   891 LKLIKSAKQMTNMTNLSGSRINSPKRGGEFMHSASPMIMDMMAEKGNFIYTD--------NRSYA 947

  Fly   950 QIDVVPTSDVDQELIPEVEPHLPHRHHHHHHHRHHHHHHQPDQEHDRNPSPPE 1002
            |.|:...|.       :::.:|.:||..|.::......| |...::.||:..|
Zfish   948 QKDIYGDSS-------DLQSYLTNRHKDHLNNYIFQGQH-PLTLNESNPNTVE 992

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	87/437 (20%)
		ANF_receptor	39..379	CDD:279440	81/412 (20%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	105/403 (26%)
		Lig_chan	548..812	CDD:278489	73/287 (25%)
grin2aa	XP_021329529.1	PBP1_iGluR_NMDA_NR2	33..389	CDD:107373	81/402 (20%)
		PBP2_iGluR_NMDA_Nr2	400..799	CDD:270436	114/447 (26%)
		NMDAR2_C	836..1460	CDD:313729	37/173 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591006
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740