DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and grik1b

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	XP_690040.5	Gene:	grik1b / 561540	ZFINID:	ZDB-GENE-070821-1	Length:	906	Species:	Danio rerio

Alignment Length:	874	Identity:	328/874 - (37%)
Similarity:	508/874 - (58%)	Gaps:	62/874 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FLLIALPVLADIDRSQFM-VGSIFTSDKDE----SEIAFRTAVDRANILERNVELVP--IVVY-- 64
            |:|:.|.....:...|.: :|.||.:.::|    .|:||:.||...|   ||..|:|  .:.|
Zfish    47 FILLCLMAEVGLSAQQVLRIGGIFETLENEPISVEELAFKFAVTNIN---RNRTLMPNTTLTYDI 108

  Fly    65 --ANTDDSFIMEKMVCNLISQGVIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESIPDREH 127
              .|..|||...:..|:.::.||.|:||||..||...:.|||:.|::|||...| .:.|:.:::
Zfish   109 QRINLFDSFEASRRACDQLALGVAAVFGPSHSSSVSAVQSICNALEVPHIQTRW-KHPSVDNKD- 171

  Fly   128 STMTLNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEPISNPTTVKQLGPG 192
             :..:|::||...:|:.:.:|||.:.|::.|||||....|.:||::::.....|....::||..|
Zfish   172 -SFYINLYPDYASISRAVLDIVQFYKWKAVTVVYEDATGLIRLQELIKAPSRYSIKIKIRQLPTG 235

  Fly   193 D-DHRPFLKEIKLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFG--ELS 254
            . |.||.|||:|...:.|:|..|:......:|:|...:.|:.||...|...||.:|:|..  ..|
Zfish   236 SKDARPLLKEMKKGKEFCVIFDCSYQTAADVLKQLLSMGMMTEYYHFFFTTLDLYSLDLEPFRYS 300

  Fly   255 GVEANITTVRLMDPSDFHVKNVVHDWE-ER-----EKREGRYFKVDPNRVKSQMILLNDAVWLFS 313
            ||  |:|..||::..:..|.:||..|. ||     :...|    :....:.::..|:.|||::.:
Zfish   301 GV--NMTGFRLLNIDNPQVASVVEKWSMERLQAPPKPETG----LQDGMMTTEAALMYDAVYMVA 359

  Fly   314 KGLTELGIFEELTAPDLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNE-NGQRSFFTLRFME 377
            ......   .::|...|:|.|.|||.||.|.|...|.......||:|..|: :|.|..|.|..:.
Zfish   360 AASQRA---SQITVSSLQCHRHKPWRFGSRFISMFKEAQWNGLTGQIIINKTDGLRKDFDLDIIS 421

  Fly   378 LNSDG-------------FLDLATWDPVNGLDVLNDDEESEKRVGQKLSNKTFIVSSRLGAPFLT 429
            |..||             :..:..|:...||::.:.:::....|...::|:|.||::.|..|::.
Zfish   422 LKEDGLEKPLESGRFNKVWKKIGVWNSNTGLNLTDSNKDKNTNVTDSMANRTLIVTTILENPYVM 486

  Fly   430 LREPQEGEILTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDG 494
            .::..:.  |.||.|:|||.:||:.|::.:|.|.:|.::..||||||.|...: |:|:||:|||.
Zfish   487 YKKSDKP--LYGNDRFEGYCLDLLKELSNILGFSYEVKLVTDGKYGAQNDKGE-WNGMVRELIDH 548

  Fly   495 NADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLF 559
            .|||.:..||:|..|.:.:||:.||||||||||:.||......:||||:|.|.|:|:|:..|.|.
Zfish   549 VADLAVAPLTITYVREKVIDFSKPFMTLGISILYHKPNGTNPGVFSFLNPLSPDIWMYVLLACLG 613

  Fly   560 ISLLLFALARMAPDDWENPHPCK-EPEEVENIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTG 623
            :|.:||.:||..|.:|.|||||. :.:.|||.::::|:.|..:|:||.||.:::|||.|||:|.|
Zfish   614 VSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLINSVWFGVGALMQQGSELMPKALSTRIVGG 678

  Fly   624 MWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQ 688
            :||||.|::::|||||||||||..|..:.|:||:|||.|:||:|||:..||||.||:.|..|||:
Zfish   679 IWWFFTLIIISSYTANLAAFLTVERMDSPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYE 743

  Fly   689 KMWTAMESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVERKCDLVQIGGWLDYKSYGI 753
            |||..|.|...:...|.|.||::||....  ||.|||||::||..:|.|:|.||||.:|.|.||:
Zfish   744 KMWAFMSSRKNTALVKNNREGIQRVLTTD--YALLMESTSIEYISQRNCNLTQIGGLIDSKGYGV 806

  Fly   754 AMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVGGVFL 818
            ..|..||||.:::.|:|:|.|.|:|..:|.|||:    |..|  .:||..:...||:||:||:|:
Zfish   807 GTPIGSPYRDKVTIAILQLQEEGKLHMMKEKWWR----GNGC--PEEDSKEASALGVENIGGIFI 865

  Fly   819 VLGLGLLSAMVLGCTEFLW-NVKSVAIEE 846
            ||..||:.::.:...||:: :.|::.|||
Zfish   866 VLAAGLVLSVFVAIGEFIYKSRKNLDIEE 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	121/403 (30%)
		ANF_receptor	39..379	CDD:279440	112/355 (32%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	179/373 (48%)
		Lig_chan	548..812	CDD:278489	126/264 (48%)
grik1b	XP_690040.5	Periplasmic_Binding_Protein_Type_1	62..455	CDD:299141	123/407 (30%)
		ANF_receptor	80..423	CDD:279440	112/357 (31%)
		Periplasmic_Binding_Protein_Type_2	471..840	CDD:304360	179/373 (48%)
		Lig_chan	602..871	CDD:278489	133/276 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591026
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.760