Protein Alignment clumsy and Grik2

DIOPT Version :10

• Sequence 1: NP_001036373.1
• Gene: clumsy / 35394
• FlyBaseID: FBgn0026255
• Length: 1002
• Species: Drosophila melanogaster
• Sequence 2: NP_062182.1
• Gene: Grik2 / 54257
• RGDID: 2733
• Length: 908
• Species: Rattus norvegicus
• Alignment Length: 881
• Identity: 341/881 - (38%)
• Similarity: 508/881 - (57%)
• Gaps: 69/881 - (7%)

  Fly     2 YSLFLTHFLLIALPVLADIDRSQFMVGSIF----TSDKDESEIAFRTAVDRANILERNVELVP-- 60
            ||...||.|               ..|.||    :......|:|||.||   |.:.||..|:|
  Rat    28 YSQGTTHVL---------------RFGGIFEYVESGPMGAEELAFRFAV---NTINRNRTLLPNT 74

  Fly    61 IVVY----ANTDDSFIMEKMVCNLISQGVIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNES 121
            .:.|    .|..|||...|..|:.:|.||.||||||..||::.:.|||:.|.:|||...|  ...
  Rat    75 TLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRW--KHQ 137

  Fly   122 IPDREHSTMTLNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEPISNPTTV 186
            :.|.:.| ..::::||...||:.:.::||.|.|::.||||:....|.:||::::.....:....:
  Rat   138 VSDNKDS-FYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKI 201

  Fly   187 KQLGPGD--DHRPFLKEIKLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSID 249
            :|| |.|  |.:|.|||:|...:..:|..|:.:....||:||..:.|:.||.......||..::|
  Rat   202 RQL-PADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALD 265

  Fly   250 FG--ELSGVEANITTVRLMDPSDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMI--------- 303
            ..  ..|||  |:|..|:::..:..|.:::..| ..|:.:.      |.:..|.::
  Rat   266 VEPYRYSGV--NMTGFRILNTENTQVSSIIEKW-SMERLQA------PPKPDSGLLDGFMTTDAA 321

  Fly   304 LLNDAVWLFSKGLTELGIFEELTAPDLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNE-NGQ 367
            |:.|||.:.|..:.:   |.::|...|:|.|.|||.||.|.:..||....|..||||.||: ||.
  Rat   322 LMYDAVHVVSVAVQQ---FPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGL 383

  Fly   368 RSFFTLRFMELNSDGFLDLATWDPVNGLDVLNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLRE 432
            |:.|.|..:.|..:|...:.||||.:||::....:.....:...|||::.||::.|..|::..::
  Rat   384 RTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKK 448

  Fly   433 PQEGEILTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNAD 497
            ..:.  |.||.|:|||.|||:.|::.:|.|.:|.|:..||||||.:.|...|:|:||:|||..||
  Rat   449 SDKP--LYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKAD 511

  Fly   498 LGICDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISL 562
            |.:..|.:|..|.:.:||:.||||||||||:.||......:||||:|.|.|:|:|:..|.|.:|.
  Rat   512 LAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSC 576

  Fly   563 LLFALARMAPDDWENPHPCK-EPEEVENIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMWW 626
            :||.:||.:|.:|.|||||. :.:.|||.::::|:.|..:|:||.||.:::|||.|||:|.|:||
  Rat   577 VLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMRQGSELMPKALSTRIVGGIWW 641

  Fly   627 FFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQKMW 691
            ||.|::::|||||||||||..|..:.|:||:|||.|:||:|||:..|:||.||:.|..|||.|||
  Rat   642 FFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMW 706

  Fly   692 TAMESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVERKCDLVQIGGWLDYKSYGIAMP 756
            ..|.|...||..|:|:||::||....  |||||||||:|:..:|.|:|.||||.:|.|.||:..|
  Rat   707 AFMSSRRQSVLVKSNEEGIQRVLTSD--YAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTP 769

  Fly   757 FNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVGGVFLVLG 821
            ..||||.:|:.|:|:|.|.|:|..:|.|||:    |..|  .:|:..:...||::|:||:|:||.
  Rat   770 MGSPYRDKITIAILQLQEEGKLHMMKEKWWR----GNGC--PEEESKEASALGVQNIGGIFIVLA 828

  Fly   822 LGLLSAMVLGCTEFLWNVKSVAIEEKISLKEAFKSE 857
            .||:.::.:...|||:..|..|..||.|...|...|
  Rat   829 AGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEE 864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	27..397	CDD:380605	128/393 (33%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	182/373 (49%)
Grik2	NP_062182.1	PBP1_iGluR_Kainate	37..414	CDD:380605	128/395 (32%)
		Periplasmic_Binding_Protein_Type_2	430..800	CDD:473866	182/373 (49%)