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Protein Alignment clumsy and Gria3

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_001268858.2	Gene:	Gria3 / 53623	MGIID:	95810	Length:	888	Species:	Mus musculus

Alignment Length:	859	Identity:	288/859 - (33%)
Similarity:	450/859 - (52%)	Gaps:	70/859 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VGSIFTSDKDESEIAFRTAVD----RANILERNVELVPIVVYANTDDSFIMEKMVCNLISQGVIA 87
            :|.:|..:..:...|||.||.    ..|..|:...|...|.:.::.:||.:....|:..|:||.|
Mouse    30 IGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYA 94

  Fly    88 IFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESIPDREHSTMTLNVHPDNLLLSQGLAEIVQSF 152
            |||.....|.:.:.|.|..|....:      ..|.|........:.:.|   .|...:..::..:
Mouse    95 IFGFYDQMSMNTLTSFCGALHTSFV------TPSFPTDADVQFVIQMRP---ALKGAILSLLGYY 150

  Fly   153 AWRSFTVVYETDKELQQLQDILQVGEPISNPTTVKQLGPGDDHRPF---LKEIKLSTDNCLILHC 214
            .|..|..:|:|::....||.|::.....:...|.:.:|...|.:.|   ::|:....:...::.|
Mouse   151 KWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDIQEFRRIIEEMDRRQEKRYLIDC 215

  Fly   215 APDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFGEL-------SGVEANITTVRLMDPSDFH 272
            ..:.:..||:|   :.:||::...:..:|  .::.|.::       .|  ||||..::::..:..
Mouse   216 EVERINTILEQ---VVILGKHSRGYHYML--ANLGFTDIVLERVMHGG--ANITGFQIVNNENPM 273

  Fly   273 VKNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDAVWLFSKGLTEL-----GIFEELTAPDLEC 332
            |:..:..|...::||....|..|  :|....|.:||:.:.::....|     .:....:|.|...
Mouse   274 VQQFIQRWVRLDEREFPEAKNAP--LKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLA 336

  Fly   333 RRKKPWPFGKRIIEFIKARSEETSTGRIDFNENGQRSFFTLRFMELNSDGFLDLATWD------P 391
            ....||..|..|...:|....:..||.|.|:..|:|:.:|:...|:...|......|:      |
Mouse   337 NPAVPWSQGIDIERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVP 401

  Fly   392 VNGLDVLNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLREPQEGEILTGNSRYEGYSIDLINEI 456
            .:...:.||...||        |:|.:|::.|.:|::..::..|.  |.||.|||||.:||..||
Mouse   402 FSDQQISNDSSSSE--------NRTIVVTTILESPYVMYKKNHEQ--LEGNERYEGYCVDLAYEI 456

  Fly   457 AKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMT 521
            ||.:..|::..:..||||||.:..|:.|:|:|.:|:.|.||:.:..||:|..|.:.:||:.|||:
Mouse   457 AKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMS 521

  Fly   522 LGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDW------ENPHP 580
            |||||:..||......:||||.|.:.::|:.:..||:.:|::||.::|.:|.:|      |.|..
Mouse   522 LGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRD 586

  Fly   581 CKEPEEVENIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMWWFFALMMLNSYTANLAAFLT 645
            .:.|.:..|.:.|.|:.|.|:|:.|.|||||.|::.|.|:|.|:||||.|::::|||||||||||
Mouse   587 PQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLT 651

  Fly   646 NSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTKTNDEGV 710
            ..|..:.|.||||||.|::|.||.:..|||..|||.|..:.|:|||:.|:||.|||||||..:||
Mouse   652 VERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGV 716

  Fly   711 ERVQKGKNLYAFLMESTTLEYNVERK-CDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLGE 774
            .||:|.|..:|||:|||..||..:|| ||.:::||.||.|.||:|.|..|..|..::.|||||.|
Mouse   717 ARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRTPVNLAVLKLSE 781

  Fly   775 LGQLAELKRKWWKEMHGGGNCEKSDEDGGD-TPELGLENVGGVFLVL--GLGLLSAMVLGCTEFL 836
            .|.|.:||.|||   :..|.|...|....| |..|.|.||.|||.:|  ||||  ||::...||.
Mouse   782 QGILDKLKNKWW---YDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGL--AMMVALIEFC 841

  Fly   837 WNVKSVAIEEKISL 850
            :  ||.|..:::.|
Mouse   842 Y--KSRAESKRMKL 853

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.