back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and Gria1

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_113796.1	Gene:	Gria1 / 50592	RGDID:	621531	Length:	907	Species:	Rattus norvegicus

Alignment Length:	962	Identity:	312/962 - (32%)
Similarity:	487/962 - (50%)	Gaps:	98/962 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYSLFLTHFLLIALPVLADIDRSQFMVGSIFTSDKDESEIAFRTAVDRANILERNVELVPIVVYA 65
            :::.|.|.||  ...|.|:.. :...:|.:|.:.:.:...|||.|:.:   |....:|:|.:...
  Rat     4 IFAFFCTGFL--GAVVGANFP-NNIQIGGLFPNQQSQEHAAFRFALSQ---LTEPPKLLPQIDIV 62

  Fly    66 NTDDSFIMEKMVCNLISQGVIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESIPDREHSTM 130
            |..|||.|....|:..|:||.||||.....:.:::.|.|..|.:..|      ..|.|....:..
  Rat    63 NISDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFI------TPSFPVDTSNQF 121

  Fly   131 TLNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQ-VGEPISNPTTVKQLGPGDD 194
            .|.:.|:   |.:.|..|:..:.|::|..:|:.|:.|..||.:|. ..|.....|.|..|...::
  Rat   122 VLQLRPE---LQEALISIIDHYKWQTFVYIYDADRGLSVLQRVLDTAAEKNWQVTAVNILTTTEE 183

  Fly   195 -HRPFLKEIKLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFGELSGVEA 258
             :|...::::...:..:::.|..:.|..||.|..:|:..|......:..|....||..:.....|
  Rat   184 GYRMLFQDLEKKKERLVVVDCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDLNKFKESGA 248

  Fly   259 NITTVRLMDPSDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDAVWLFSKGLTEL---- 319
            |:|..:|::.:|.....::..|...:.|:  :.:||..|.|....|..|.|.:.::....|
  Rat   249 NVTGFQLVNYTDTIPARIMQQWRTSDSRD--HTRVDWKRPKYTSALTYDGVKVMAEAFQSLRRQR 311

  Fly   320 -GIFEELTAPDLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNENGQRSFFTLRFMELNSDGF 383
             .|.....|.|.......||..|..|...::....|..||.:.|||.|:|:.:||..:|:..||.
  Rat   312 IDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGI 376

  Fly   384 LDLATWDPVNGLDVLNDDEE-----SEKRVG---QKLSNKTFIVSSRLGAPFLTLREPQEGEILT 440
            ..:..|         |:|::     ::.:.|   ..:.|:|:||::.|..|::.|:  :......
  Rat   377 RKIGYW---------NEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYVMLK--KNANQFE 430

  Fly   441 GNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTM 505
            ||.|||||.::|..||||.:.:.:...:..||||||.:..|:.|:|:|.:|:.|.||:.:..||:
  Rat   431 GNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTI 495

  Fly   506 TSSRRQAVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARM 570
            |..|.:.:||:.|||:|||||:..||......:||||.|.:.::|:.:..||:.:|::||.::|.
  Rat   496 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRF 560

  Fly   571 APDDWENPHPCKEPEEVE-----------NIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGM 624
            :|.:|.:       ||.|           |.:.|.|:.|.|:|:.|.|||||.|::.|.|:|.|:
  Rat   561 SPYEWHS-------EEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGV 618

  Fly   625 WWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQK 689
            ||||.|::::|||||||||||..|..:.|.||||||.|::|.||.:..|||..|||.|..:.::|
  Rat   619 WWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEK 683

  Fly   690 MWTAMESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVERK-CDLVQIGGWLDYKSYGI 753
            |||.|:||.||||.:|.:||:.||:|.|..||:|:|||..||..:|| ||.:::||.||.|.|||
  Rat   684 MWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGI 748

  Fly   754 AMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGD-TPELGLENVGGVF 817
            |.|..|..|..::.|||||.|.|.|.:||.|||   :..|.|.....|..| |..|.|.||.|||
  Rat   749 ATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWW---YDKGECGSGGGDSKDKTSALSLSNVAGVF 810

  Fly   818 LVL--GLGLLSAMVLGCTEFLW-------NVKSVAIEEKISLKEAFKSEALFAARIWITTKPVHT 873
            .:|  ||||  ||::...||.:       .:|...:..:.|:.||            |.|..:..
  Rat   811 YILIGGLGL--AMLVALIEFCYKSRSESKRMKGFCLIPQQSINEA------------IRTSTLPR 861

  Fly   874 SSESGSSNSSSSSSSRSKHSFKSQGLSMKSLKSSGYQDVEASVHSKLKKIGS 925
            :|.:|:|....|..:       .:.:|....||  .|.:....||....:|:
  Rat   862 NSGAGASGGGGSGEN-------GRVVSQDFPKS--MQSIPCMSHSSGMPLGA 904

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.