DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and grid2

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_001004123.1	Gene:	grid2 / 448841	ZFINID:	ZDB-GENE-040913-1	Length:	1009	Species:	Danio rerio

Alignment Length:	1084	Identity:	273/1084 - (25%)
Similarity:	464/1084 - (42%)	Gaps:	218/1084 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LFL-THFLLIALPVLADIDRSQFMVGSIFTSDKDESEIAFRTAVDRANILERNVELVPIVV---Y 64
            ||| |.:.|...|||.|   |...:|:||.....:.:..||.||...|:....:|...|.|   :
Zfish     8 LFLITFWSLEWEPVLPD---SIIHIGAIFDESAKKDDEVFRMAVADLNLNNEILETEKITVSVEF 69

  Fly    65 ANTDDSFIMEKMVCNLISQGVIAIFGPSTGSSSDIIASICDTLDIPHIVYD----WIPNESIPDR 125
            .:.::.|...:..|.|:::|::|:.......|:..:.|:.|.:.|||:...    ..|..|.|.
Zfish    70 VDGNNPFQAVQEACELMNRGILALVSSIGCMSAGSLQSLADAMHIPHLFIQRAPAGTPRSSCPP- 133

  Fly   126 EHSTMTLNVHPDN--------LLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDIL----QVGE 178
                 |....||:        :.|:..:.::|..:.|:.|.:.|:||.:::.:::.|    |.|.
Zfish   134 -----TTRAQPDDYTLFVRPPVYLNDVIFQVVMEYTWQKFIIFYDTDYDIRGIENFLDQTSQQGM 193

  Fly   179 PISNPTTVKQLGPGDDHRPFLKEIKLSTDNCLI-----------LHCAPDNLLKILQQANELKML 232
            .:|                 |:::: |..|.:|           ||...|.|.:.:     |.|.
Zfish   194 DVS-----------------LQKVE-SNINMMITGMFRTMRVEELHRYRDTLRRAV-----LFMS 235

  Fly   233 GEYQSVFI-PLLDTHSIDFG--------ELSGVE---------ANITTVRLMDPSDFHVKNVVHD 279
            ......|| .:::|:.:.|.        |:|.::         ..:|.||...|       :..:
Zfish   236 PATAKAFITEVVETNLVAFDCQWIIINEEISDMDVQELVMKSIGRLTLVRQTFP-------LPQN 293

  Fly   280 WEEREKREGRYFKV---DPNRVKSQMILLNDAVWLFSKGLTELGIFEEL-------TAPDLECRR 334
            ..:|..|.......   ||...|:||:.:.:. :::...|.....|...       :...|.|.|
Zfish   294 TSQRCVRNNHRINTSLCDPKDPKAQMLEITNR-YIYDTVLLLANTFHRKLEDRKWHSMASLSCIR 357

  Fly   335 K--KPWPFGKRIIEFIKARSEETSTGRIDFNENGQRSFFTLRFMELN-----SDGFLDLATWDPV 392
            |  |||..||.::|.:|.......|..::||:||.........:..|     ..|...||||||:
Zfish   358 KGSKPWQGGKSMLETVKKGGVSGLTSLLEFNDNGSNPNIHFEILGTNYGEDRGRGVSRLATWDPI 422

  Fly   393 NGLD-VLNDDEESEKRVGQKLSNK----TFIVSSRLGAPFLTLREPQEGEILTGNSRYEGYSIDL 452
            :||: .|.|         :||.|.    ...|.:.|..||:.:.|    .:|....:|:|:|||:
Zfish   423 HGLNGTLTD---------RKLENNMRGVVLRVVTVLEEPFVMVSE----NVLGKPKKYQGFSIDV 474

  Fly   453 INEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTP 517
            ::.:|..|.||:|..::||.|||: .:...||:|::.:|:...||:|:..||:|..|...||||.
Zfish   475 LDALANYLGFKYEIYVAPDHKYGS-QQADGTWNGLIGELVFKRADVGLSALTITPERESVVDFTT 538

  Fly   518 PFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENPHPCK 582
            .:|...:.:|..|... ..|:|:.|:||.|.:|..:....|.:..|::.|      :|.||.  :
Zfish   539 RYMDYSVGVLLRKAER-TVDMFACLAPFDLSLWACIAGTVLLVGTLVYLL------NWLNPP--R 594

  Fly   583 EPEEVENIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMWWFFALMMLNSYTANLAAFLTNS 647
            .|....:..::.|:.|...||.:.||.::.....:||::.|:||.|||::::|||||||||||.|
Zfish   595 LPMGSVSSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGVWWLFALIVISSYTANLAAFLTIS 659

  Fly   648 RQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFS------TYQKMWTAME---SASPSVFT 703
            |..|||.|.:|||.|:.:.||.:...:.....|....:      .|.:||..:.   .|..:|
Zfish   660 RIENSIQSLQDLAKQTDLPYGTVLDSAVYDQVRSKGMNPFERDPMYSQMWRMINRTGGAENNV-- 722

  Fly   704 KTNDEGVERVQKGKNLYAFLMESTTLEYNV--ERKCDLVQIGGWLDYKSYGIAMPFNSPYRKQIS 766
            :.:.||:.:|:.|:  :||:.::..|||..  :..|.|..:...:..:.||:||...||||...|
Zfish   723 EESKEGIRKVKYGR--FAFVWDAAVLEYVAINDEDCSLYTVSNNVADRGYGMAMQHGSPYRDIFS 785

  Fly   767 AAVLKLGELGQLAELKRKWWK-----EMHGGGNCEKSDEDGGDTPELGLENVGGVFLVLGLGLLS 826
            ..:|:|.:.|.:..||.|||.     :::......||..      .|.:.:..|||.||..|::.
Zfish   786 QRILELQQNGDMDILKLKWWPRDSPCDLYSPVGTRKSGS------ALDIHSFAGVFFVLAAGVVL 844

  Fly   827 AMVLGCTEFLW------------------------NVKSVAIEEKISLKEAFKS---------EA 858
            :.::...|..|                        .|.|:..|::...|:...|         ::
Zfish   845 SCLIATVETWWTRRKGSRVPSKEDDKEIDLEHLHHRVNSLCTEDESPHKQFSTSSIDLTPLDMDS 909

  Fly   859 LFAAR-------------IWITT---KPVHTSSESGSSNSSSSSSSRSKHSFKSQGLSMKSLKSS 907
            |.|||             |..||   :.:.|.|.|.|:.:::..:..:....::.|...:...:.
Zfish   910 LPAARQALEQISDFRNTHITTTTFIPEQIQTLSRSLSAKAAAGFAFGAVQDHRTGGPFRQRAPNG 974

  Fly   908 GYQDVEASVHSKLKKIGSMFSLKSQKTVTPPPEIGWKLDKSTQI 951
            |:      ..|.:|   :|.|:..|.|..|....|...|:.|.|
Zfish   975 GF------FRSPVK---TMSSIPYQPTPAPNFSYGNDPDRGTSI 1009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	93/434 (21%)
		ANF_receptor	39..379	CDD:279440	81/399 (20%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	124/387 (32%)
		Lig_chan	548..812	CDD:278489	82/279 (29%)
grid2	NP_001004123.1	PBP1_iGluR_delta_2	28..427	CDD:107386	94/435 (22%)
		ANF_receptor	42..404	CDD:279440	81/398 (20%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	123/383 (32%)
		Lig_chan	568..841	CDD:278489	87/290 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	989..1009		6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591020
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.740