DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and Ekar

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster

Alignment Length:	979	Identity:	318/979 - (32%)
Similarity:	495/979 - (50%)	Gaps:	160/979 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LFLTHFLL-------IALPVLADIDRSQFMVGSIFTSDKD--ESEIAFRTAVDRANILERNVELV 59
            |..:.|||       :.:|.|.       .:|:||::...  .||:|||.|:.|.|:   :..|:
  Fly     2 LIASGFLLFQFLSYGLGVPPLV-------RIGAIFSNQPGMYNSELAFRYAIHRLNM---DKSLL 56

  Fly    60 P------IVVYANTDDSFIMEKMVCNLISQGVIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIP 118
            |      .|.|.|..|||...:.||.||..||.|:|.|:....:..|.||||.||||:|
  Fly    57 PETTVDYYVEYVNRFDSFETVQKVCKLIRVGVQAVFSPTDSVLATHINSICDALDIPNI------ 115

  Fly   119 NESIPDREHSTMTLNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEPISNP 183
                 .|.....::||:|...|::....:::|...|..|.:::|.:..:..|.   |:.......
  Fly   116 -----GRSAHDFSINVYPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLH---QLSRSFHGE 172

  Fly   184 TTVKQLGPGDDHRPFLKEIKLSTDNCLILHCAPDN---LLK--ILQQANELKMLGEYQSVFIPL- 242
            ..::|:. .|.:...|.|.|....:.:|:....:.   |||  :.||.||.|    |..:|...
  Fly   173 VHMRQVS-RDSYVSALNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYK----YHYLFTSFD 232

  Fly   243 LDTHSIDFGELSGVEANITTVRLMDPSDFHVKNVVHDWEEREKREGRY----FK-------VDPN 296
            |:|:.::..:.:.|  |||:.||:|.:|..||.::.|       .|.|    ||       :..:
  Fly   233 LETYDLEDFKYNFV--NITSFRLVDTADVGVKQILKD-------IGLYSHHIFKKPYLNLHIKKS 288

  Fly   297 RV-KSQMILLNDAVWLFSKGLTELGIFEELTAPDLECRRKKPWPFGKRIIEFIKARSEETSTGRI 360
            .: :|:..|:.|:|::|:.||..|.....||..::.|..:..|..|..:|.::.|...:..||.|
  Fly   289 TILESEPALMFDSVYVFAIGLQTLEQSHSLTLLNISCEEENSWDGGLSLINYLNAVEWKGLTGPI 353

  Fly   361 DFNENGQRSFFTLRFMELNSDGFLDLATWDPVNGLDVLNDDEESEKRVGQKLSNKTFIVSSRLGA 425
            .| ::|||..|.|..::|.....:.:..|.|...|::    .|..........|.|.:|.:.|..
  Fly   354 QF-KDGQRVQFKLDLIKLKQHSIVKVGEWTPHGHLNI----TEPSMFFDAGSMNVTLVVITILET 413

  Fly   426 PFLTLREPQEGEILTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQ 490
            |::.:   ..|:..|||.|:.|:.:|::..|::.:.|.:...:.||.||||.:..|..|:|:|.|
  Fly   414 PYVMM---HYGKNFTGNERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQ 475

  Fly   491 LIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGS 555
            |:...|||.:..:|:|.:|...:|||.|||.|||||||..|.:.||.||||::|.::::|||:..
  Fly   476 LMKYKADLAVGSMTITYARESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLI 540

  Fly   556 AYLFISLLLFALARMAPDDWENPHPCKEPEEVENI-----WSIMNTTWLSIGSLMGQGCDILPKA 615
            ||..:||.::.:.:::|.:|:..:.|    ::|||     :|:.::.|.:||:.|.|..||.|:|
  Fly   541 AYFLVSLCIYIVGKLSPIEWKCINAC----DLENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRA 601

  Fly   616 ASTRLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFR 680
            .|||:::..|.||:|:::.|||||||||||..|..|.|.:|||||:|::|.||.:..||||.|||
  Fly   602 MSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFR 666

  Fly   681 DSNFSTYQKMWTAMESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVERKCDLVQIGGW 745
            ||...||:|:|.:|::..||.||.|.::|::||.:|.  ||||||||.|:|.|:|.|:|.||||.
  Fly   667 DSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQGN--YAFLMESTMLDYIVQRDCNLTQIGGL 729

  Fly   746 LDYKSYGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNC-EKSDEDGGDTPELG 809
            ||.|.||||.|..||:|.:||.|:|:|.|.|.:..|..||||  :....| .|:.........||
  Fly   730 LDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWK--NTDETCTRKNTSKQSKANSLG 792

  Fly   810 LENVGGVFLVLGLGLLSAMVLGCTEFLWNVKSVAIEEKISLKEAFKSEALFAARIWITTKPVHTS 874
            ||::||||:||..|::.|.|:...||.:|.:             :..||              |.
  Fly   793 LESIGGVFVVLIAGIIVAAVVAFFEFWYNFR-------------YNYEA--------------TP 830

  Fly   875 SESGSSNSSSSSSSRSKHSFKSQGLSMKSLKSSGYQDVEASVHSKLKKIGSMFSLKSQKTVTPPP 939
            |:|..:|           .:...|:                             |:|::..|||.
  Fly   831 SQSVVNN-----------KYNQDGI-----------------------------LESERNYTPPD 855

  Fly   940 EIGW 943
            ...|
  Fly   856 RSFW 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	109/395 (28%)
		ANF_receptor	39..379	CDD:279440	102/363 (28%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	168/377 (45%)
		Lig_chan	548..812	CDD:278489	122/269 (45%)
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	109/395 (28%)
		ANF_receptor	39..371	CDD:279440	102/363 (28%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	168/377 (45%)
		Lig_chan	533..807	CDD:278489	129/281 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462691
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6275
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	10	9.700