DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and gria4a

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_999971.1	Gene:	gria4a / 407735	ZFINID:	ZDB-GENE-020125-7	Length:	898	Species:	Danio rerio

Alignment Length:	892	Identity:	297/892 - (33%)
Similarity:	462/892 - (51%)	Gaps:	68/892 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLIALPVLADIDRSQF----MVGSIFTSDKDESEIAFRTAV----DRANILERNVELVPIVVYAN 66
            :|:.:|:|..:....|    .:|.:|..:.|:...|||.|:    ...|..|....|||.|....
Zfish     3 ILVLIPLLWGLGEGAFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNATEAPFNLVPHVDNIE 67

  Fly    67 TDDSFIMEKMVCNLISQGVIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESIPDREHSTMT 131
            |.:||.:....|:..|:||.||||.....|...:.|.|..|.|.      :...|.|....:...
Zfish    68 TANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHIS------LVTPSFPAEGETQFV 126

  Fly   132 LNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDIL----QVGEPISNPTTVKQLGPG 192
            |.:.|.   :...|..::..:.|..|..:|:||:....||.|:    |.|..:| ...|:.....
Zfish   127 LQLRPS---IRGALLSLLDHYDWSRFVFLYDTDRGYAVLQAIMEKAGQNGWQVS-AICVENFNDA 187

  Fly   193 DDHRPFLKEIKLSTDNCLILHCAPDNLLKILQQANEL-KMLGEYQSVFIPLLDTHSIDFGELSGV 256
             .:|..|:::....:...::....:.|..||:|...: |.:..|..: :..|....|........
Zfish   188 -SYRRLLEDLDRRQEKKFVIDLEAERLQNILEQIVSVGKHVKGYHYI-VANLGFKDISLERFMHG 250

  Fly   257 EANITTVRLMDPSDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDAVWLFSKGLTEL-- 319
            .||:|..:|:|.|...|..::..|.:.::||....:..|....|   |..|.|.:.::....|
Zfish   251 GANVTGFQLVDFSKPMVIKLMQRWNKLDQREYPGSESPPRYTSS---LTYDGVLVMAEAFRNLRR 312

  Fly   320 ---GIFEELTAPDLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNENGQRSFFTLRFMELNSD 381
               .|.....|.|.......||..|..:...:|....:..||.|.|:..|:|..:|:...||.|:
Zfish   313 QKIDISRRGNAGDCLANPAAPWNQGIDMERTLKQVRIQGLTGNIQFDHYGRRVNYTMDVFELKSN 377

  Fly   382 GFLDLATWDPVNGLDVLNDDEESEKRVG--QKLSNKTFIVSSRLGAPFLTLREPQEGEILTGNSR 444
            |...:..|:.::.|.::    ::|..:|  ..:.|:|.||::.:..|::.|:  :..|:..||.:
Zfish   378 GPRKIGYWNDLDKLVLV----QNELSMGNDSAMENRTVIVTTIMEGPYVMLK--KNWEMYEGNEQ 436

  Fly   445 YEGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSR 509
            :|||.:||.:|:||.:..|::..:..||||||.:..|:.|:|:|.:|:.|.|::.:..|.:|..|
Zfish   437 FEGYCVDLASEVAKHIGIKYKISIVLDGKYGARDPETKIWNGMVGELVYGKAEIAVAPLAITLVR 501

  Fly   510 RQAVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDD 574
            .:.:||:.|||:|||||:..||......:||||.|.:.::|:.:..||:.:|::||.::|.:|.:
Zfish   502 EEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYE 566

  Fly   575 WENPHPCKEPEE---------VENIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMWWFFAL 630
            |..    :||||         ..|.:.|.|:.|.|:|:.|.||||..|::.|.|:|.|:||||.|
Zfish   567 WHT----EEPEEGSDGPPSDQPPNEFGIFNSLWFSLGAFMQQGCDFTPRSLSGRIVGGVWWFFTL 627

  Fly   631 MMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAME 695
            ::::|||||||||||..|..:.|.||||||.|::|.||.:..|||..|||.|..:.|:|||:.|:
Zfish   628 IIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMK 692

  Fly   696 SASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVERK-CDLVQIGGWLDYKSYGIAMPFNS 759
            ||.|:|||||..|||.||:|.|..||||:|||..||..:|| ||.:::||.||.|.||:|.|..|
Zfish   693 SAEPTVFTKTTAEGVARVRKSKGKYAFLLESTMNEYTEQRKPCDTMKVGGNLDSKGYGVATPKGS 757

  Fly   760 PYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGD--TPELGLENVGGVFLVL-- 820
            .....::.|||||.|.|.|.:||.|||   :..|.|...|....|  :..|.|.||.|||.:|
Zfish   758 QLGTPVNLAVLKLSEAGVLDKLKNKWW---YDKGECGPKDSGSKDKSSQALSLSNVAGVFYILVG 819

  Fly   821 GLGLLSAMVLGCTEFLWNVKSVAIEEKISLKEAFKSEALFAARIWIT 867
            ||||  ||::...||.:..::.|.:.|::..||.:::    ||:.||
Zfish   820 GLGL--AMLVALVEFCYKSRAEAKKLKLTFSEAMRNK----ARLSIT 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	91/383 (24%)
		ANF_receptor	39..379	CDD:279440	84/353 (24%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	170/382 (45%)
		Lig_chan	548..812	CDD:278489	126/275 (46%)
gria4a	NP_999971.1	PBP1_iGluR_AMPA_GluR4	23..393	CDD:107383	92/384 (24%)
		ANF_receptor	34..375	CDD:279440	84/355 (24%)
		PBP2_iGluR_AMPA_GluR4	408..790	CDD:270445	172/390 (44%)
		Lig_chan	540..821	CDD:278489	132/287 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591043
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850