DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and gria1b

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_991293.1	Gene:	gria1b / 403044	ZFINID:	ZDB-GENE-020125-2	Length:	917	Species:	Danio rerio

Alignment Length:	953	Identity:	317/953 - (33%)
Similarity:	469/953 - (49%)	Gaps:	151/953 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FLLIALPVLADIDRSQF----MVGSIFTSDKDESEIAFRTAVDRANILERNVELVPIVVYANTDD 69
            |:|:...:|.....|.|    .:|.:|.:|..|.:: ||.|:.:.|.:.:   |||.|...:|..
Zfish     5 FVLLLTGLLGLCSCSSFPSNINIGGLFPTDSHEYDV-FRFALSQHNDVPK---LVPQVDMVDTGS 65

  Fly    70 SFIMEKMVCNLISQGVIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESIPDREHSTMTLNV 134
            ||.|....|:..|:||.||.|.....:.:::.|.|..|   |:.:   ...|.|...::...:.:
Zfish    66 SFAMTYAFCSQFSKGVYAIIGLYDRKTMNMLMSFCGAL---HVCF---VTPSFPIDTNNQFVIQL 124

  Fly   135 HPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEPIS------NPTTVKQLGPGD 193
            .|:   |...|..:|:.:.|..|..:|.:|..|..||.||......:      |..|:.:..
Zfish   125 RPE---LQDALIALVEHYKWNKFVYMYSSDSGLTVLQKILDTAAEKTWQVTSINFDTLTEAA--- 183

  Fly   194 DHRPFLKEIKLSTDN----CLILHCAPDNLLKILQQ-ANELKMLGEYQSVFIPL--LDTHSIDFG 251
                |||.|: ..||    .:||.|..:.|..||.. |.:.|.|..|..:...|  ||.:..:|.
Zfish   184 ----FLKAIQ-DLDNKKEFKIILDCELERLNSILNLIAAQKKNLKNYHYILANLGFLDLNLTEFR 243

  Fly   252 ELSGVEANITTVRLMDPSDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDAVWLFSKGL 316
            : .|  ||:|..:||:.::..|...:.||.|.:.::   .|....|:|....|..|.|.:.:..
Zfish   244 K-GG--ANVTGFQLMNYTNPTVSRTIQDWLEFDSKD---LKSPKRRLKYTGALTYDGVTVMATA- 301

  Fly   317 TELGIFEELTAPDL---------ECRRKKPWPFGKRI--------IEFIKARSEETSTGRIDFNE 364
                 |:.|....:         ||....|.|:|:.|        ::|      |..||.:.||:
Zfish   302 -----FQNLRKQRIDISRRGNAGECLANPPAPWGQGIDIQRALQQVQF------EGLTGHVQFND 355

  Fly   365 NGQRSFFTLRFMELNSDGFLDLATWDPVNGLDVLNDDEESEKRVGQK-----------LSNKTFI 418
            .|.|:.||:..||....|...:..|:            :.||.|...           |.|:|::
Zfish   356 KGHRTNFTVSVMEFGPSGPKKVGYWN------------QREKYVSTATYSNMLNETFGLQNRTYV 408

  Fly   419 VSSRLGAPFLTLREPQEGEILTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQT 483
            |::.|.||::.|::..|.  |.||.:||||.::|..||||.:.:.:...:..||||||.:..|..
Zfish   409 VTTILEAPYVMLKKNHEQ--LVGNDKYEGYCVELAAEIAKHVGYSYRLELVGDGKYGARDAETMM 471

  Fly   484 WDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLD 548
            |:|:|.:|:.|.||:.:..||:|..|.:.:||:.|||:|||||:..||......:||||.|.:.:
Zfish   472 WNGMVGELVYGKADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPTKSKPGVFSFLDPLAYE 536

  Fly   549 VWIYMGSAYLFISLLLFALARMAPDDW-------------ENPHPCKEPE--------------- 585
            :|:.:..||:.:|::||.::|.:|.:|             :|..|..||.
Zfish   537 IWMCIVFAYIGVSVVLFLVSRFSPYEWHADDEEETADQQNQNQPPSPEPNQSPNQSQNQREEKQE 601

  Fly   586 ---EVENIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMWWFFALMMLNSYTANLAAFLTNS 647
               |..|.:.|.|:.|.|:|:.|.|||||.|::.|.|:|.|:||||.|::::|||||||||||..
Zfish   602 KQPEHTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVE 666

  Fly   648 RQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTKTNDEGVER 712
            |..:.|.||||||.|::|.||.:.||||..|||.|..:.::|||:.|:||.|:||.||.||||.|
Zfish   667 RMVSPIESAEDLAKQTEIAYGTLDGGSTKEFFRRSKIAVFEKMWSYMKSAEPTVFVKTTDEGVVR 731

  Fly   713 VQKGKNLYAFLMESTTLEYNVERK-CDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLGELG 776
            |:|.|..||:|:|||..||..:|| ||.:::||.||.|.||:|.|..|..|..::.|||||.|.|
Zfish   732 VRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNPVNLAVLKLNEQG 796

  Fly   777 QLAELKRKWWKEMHGGGNCEKSDEDGGD-TPELGLENVGGVFLVL--GLGLLSAMVLGCTEFLWN 838
            .|.:||.|||   :..|.|.....|..| |..|.|.||.|||.:|  ||||  ||::...||.:.
Zfish   797 LLDKLKNKWW---YDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGL--AMLVALVEFCYK 856

  Fly   839 VKSVAIEEKISLKEAFKSEALFAARIWITTKPVHTSSESGSSN 881
            .:..:...|..:..|..|..|             |...||..|
Zfish   857 SRIESRRMKQIIDAAMLSSTL-------------TRMGSGGEN 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	102/399 (26%)
		ANF_receptor	39..379	CDD:279440	96/369 (26%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	176/404 (44%)
		Lig_chan	548..812	CDD:278489	129/296 (44%)
gria1b	NP_991293.1	PBP1_iGluR_AMPA_GluR1	26..387	CDD:107385	104/411 (25%)
		ANF_receptor	41..368	CDD:279440	94/364 (26%)
		PBP2_iGluR_AMPA_GluR1	404..812	CDD:270447	178/412 (43%)
		Lig_chan	536..842	CDD:278489	135/308 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591015
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.750