DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment clumsy and Ir75a

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_649012.2	Gene:	Ir75a / 39982	FlyBaseID:	FBgn0036757	Length:	629	Species:	Drosophila melanogaster

Alignment Length:	745	Identity:	150/745 - (20%)
Similarity:	282/745 - (37%)	Gaps:	183/745 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 DNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEPISNPTTVKQLGPGDDHRPFLK- 200
            |||:.|: :..||....|:|       |:.|:..|..:   :|| :|..|        :..|::
  Fly    12 DNLVQSR-IGFIVLFHCWQS-------DESLKFAQQFM---KPI-HPILV--------YHQFVQM 56

  Fly   201 -------EIKLS----TDNCLILH----CAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDF 250
                   .::||    |...|.::    |  |....:|::|:..::..::.. ::.:.:...::|
  Fly    57 RGVLNWSHLELSYMGHTQPTLAIYVDIKC--DQTQDLLEEASREQIYNQHYH-WLLVGNQSKLEF 118

  Fly   251 GELSG-----VEANITTVR--LMDPSDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDA 308
            .:|.|     ::|:::.|:  :.|.:| .|...|||.....|..|....|..:
  Fly   119 YDLFGLFNISIDADVSYVKEQIQDNND-SVAYAVHDVYNNGKIIGGQLNVTGS------------ 170

  Fly   309 VWLFSKGLTELGIFEELTAPDLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNENGQRSFFTL 373
                          .|::.....|||       .|.:..::.||           :.|.|...|
  Fly   171 --------------HEMSCDPFVCRR-------TRHLSSLQKRS-----------KYGNREQLT- 202

  Fly   374 RFMELNSDGFLDLATWDPVNGLDVLNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLREPQEGEI 438
                   |..|.:||......| .|:|||...                     ||:    ||.:.
  Fly   203 -------DVVLRVATVVTQRPL-TLSDDELIR---------------------FLS----QENDT 234

  Fly   439 LTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWD------GIVRQLIDGNAD 497
            ...:....|:.:.||  :..:|:.|.:|..|            .:|.      |.|..::|..||
  Fly   235 HIDSLARFGFHLTLI--LRDLLHCKMKFIFS------------DSWSKSDVVGGSVGAVVDQTAD 285

  Fly   498 LGICDLTMTSSRRQ---AVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLF 559
            |.......|..|.:   |:..|..|.::   .:|..|.........||.|||..||...|.....
  Fly   286 LTATPSLATEGRLKYLSAIIETGFFRSV---CIFRTPHNAGLRGDVFLQPFSPLVWYLFGGVLSL 347

  Fly   560 ISLLLFALARMAPDDWENPHPCKEPEE---VENIWSIMNTTWLSIGSLMGQGCDILPKAASTRLV 621
            |.:||:....|         .||..::   ::.:.|:::|..:|.|:...|...::|::|..||:
  Fly   348 IGVLLWITFYM---------ECKRMQKRWRLDYLPSLLSTFLISFGAACIQSSSLIPRSAGGRLI 403

  Fly   622 TGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMA---GGSTMGFFRDSN 683
            ....:..:.:|.|.||:.:.:.|.:|...:.|.:...| |:|.:..|...   ..|.:.:.|...
  Fly   404 YFALFLISFIMYNYYTSVVVSSLLSSPVKSKIKTMRQL-AESSLTVGLEPLPFTKSYLNYSRLPE 467

  Fly   684 FSTYQKMWTAMESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVERK------CDLVQI 742
            ...:.|.....::.:|.::... ::||.||:.... |.::.|:::....|||.      |||.::
  Fly   468 IHLFIKRKIESQTQNPELWLPA-EQGVLRVRDNPG-YVYVFETSSGYAYVERYFTAQEICDLNEV 530

  Fly   743 GGWLDYKSYGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPE 807
             .:...:.:...:..||.|::......|::.|.| :...:|.:|  :|...:|...:    ....
  Fly   531 -LFRPEQLFYTHLHRNSTYKELFRLRFLRILETG-VYRKQRSYW--VHMKLHCVAQN----FVIT 587

  Fly   808 LGLENVGGVFLVLGLGLLSAMVLGCTEFLW 837
            :|:|.|..:.|:|....:..:|:...|..|
  Fly   588 VGMEYVAPLLLMLICADILVVVILLVELAW 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	52/281 (19%)
		ANF_receptor	39..379	CDD:279440	48/264 (18%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	82/393 (21%)
		Lig_chan	548..812	CDD:278489	56/275 (20%)
Ir75a	NP_649012.2	Lig_chan	337..603	CDD:306551	60/285 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462588
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840