DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and GluRIA

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_476855.1	Gene:	GluRIA / 38742	FlyBaseID:	FBgn0004619	Length:	991	Species:	Drosophila melanogaster

Alignment Length:	952	Identity:	288/952 - (30%)
Similarity:	460/952 - (48%)	Gaps:	157/952 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 HFLL---IALPVLADIDRSQFMV--------GSIFTSDKDESEIAFRTAV--DRANILERNVELV 59
            ||:.   |..|..:...:.|..|        |:||....|:.:.||:.|:  ...|:..|..||.
  Fly    12 HFICASSIFWPEFSSAQQQQQTVSLTEKIPLGAIFEQGTDDVQSAFKYAMLNHNLNVSSRRFELQ 76

  Fly    60 PIVVYANTDDSFIMEKMVCNLISQGVIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESI-P 123
            ..|...||.|:|.:.:::||..|:||.::.|..:..|.|.:.|..:|..:| .|..|.|.:.: |
  Fly    77 AYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMP-FVTPWFPEKVLAP 140

  Fly   124 DREHSTMTLNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEP--------- 179
            ........:::.||   ..|.:.:.:|.:.|:|...:|::...|.:||.|.|..:|
  Fly   141 SSGLLDFAISMRPD---YHQAIIDTIQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQM 202

  Fly   180 ---ISNPT-------TVKQLGPGDDHRPFLKEIKLSTDNCLILHCAPDNLLK--ILQQANELKML 232
               |:|.|       |::.||.....|             ::|.| |..:.|  |:|...::| |
  Fly   203 VKRIANVTMAIEFLHTLEDLGRFSKKR-------------IVLDC-PAEMAKEIIVQHVRDIK-L 252

  Fly   233 GE--YQSVFIPL-LDTH----SIDFGELSGVEANITTVRLMDPSDFHVKNVVHDWEEREKREGRY 290
            |.  |..:...| :|.|    .::||.:     |||..|::|.:...|:: .||..:|.:..|:.
  Fly   253 GRRTYHYLLSGLVMDNHWPSDVVEFGAI-----NITGFRIVDSNRRAVRD-FHDSRKRLEPSGQS 311

  Fly   291 FKVD---PN---RVKSQMILLNDAVWL----FSKGLTELGIFEELTAPD---------------- 329
            ...:   ||   .:.:|..|:.|||::    |::.|.:        .||
  Fly   312 QSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRK--------KPDQFRSNHLQRRSHGGSS 368

  Fly   330 -------------LECRRKK----PWPFGKRIIEFIKARSEETSTGRIDFNENGQRSFFTLRFME 377
                         |:|...|    ||..|::|...::....:..:|.|.|:|:|:|..:||..:|
  Fly   369 SSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVE 433

  Fly   378 LNSDGFL-DLATWD------PVNGLDVLNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLREPQE 435
            ::.:..| .:|.|.      |::..:..:....:....|....|.|:||||.|..|:|:|::...
  Fly   434 MSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSSLLEEPYLSLKQYTY 498

  Fly   436 GEILTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQ-TWDGIVRQLIDGNADLG 499
            ||.|.||.|:|||..||.:.:|..|..|:|.|:..||.|||.|:... .|||:|.:||...||:.
  Fly   499 GESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVGELIRKEADIA 563

  Fly   500 ICDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLL 564
            |..:|:|:.|.:.:||:.|||||||||:..||......:||||:|.|.::||.:..:|:.:|.:|
  Fly   564 ISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVL 628

  Fly   565 FALARMAPDDW------ENPHPCKEPEEV-----------------ENIWSIMNTTWLSIGSLMG 606
            :.:.|..|.:|      :.....::|..:                 .|.::::|:.|.|:.:.|.
  Fly   629 YFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQ 693

  Fly   607 QGCDILPKAASTRLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMA 671
            |||||.|.:.:.|:...:||||.:::::|||||||||||..|....|.:.|||..|:.:.||.:.
  Fly   694 QGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLL 758

  Fly   672 GGSTMGFFRDSNFSTYQKMWTAMESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEY-NVER 735
            .|||..|||.|....:.|||..| :|:......|.|||:.||::.|..||.|:||...|| |...
  Fly   759 YGSTWEFFRRSQIGLHNKMWEYM-NANQHHSVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARP 822

  Fly   736 KCDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDE 800
            .||.:::|..:|.|.:|:|.|..||.||:::.|||.|.|.|:|..::.|||.:.   ..|....|
  Fly   823 PCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFDK---TECNLDQE 884

  Fly   801 DGGDTP-ELGLENVGGVFLVLGLGLLSAMVLGCTEFLWNVKS 841
            .  .|| ||.|.||.|::.:|..|||.|:::...||....|:
  Fly   885 T--STPNELSLSNVAGIYYILIGGLLLAVIVAIMEFFCRNKT 924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	108/458 (24%)
		ANF_receptor	39..379	CDD:279440	99/413 (24%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	155/397 (39%)
		Lig_chan	548..812	CDD:278489	100/288 (35%)
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..453	CDD:107375	106/444 (24%)
		ANF_receptor	53..434	CDD:279440	98/413 (24%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	156/405 (39%)
		Lig_chan	612..907	CDD:278489	104/300 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462514
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	169	1.000	Inparanoid score	I1556
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.790