DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and Ir64a

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster

Alignment Length:	908	Identity:	160/908 - (17%)
Similarity:	282/908 - (31%)	Gaps:	313/908 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 DKELQQLQDILQVGEP----ISNPTTVKQLGPGDDHRPFLKEIKLSTDNCLILHCAPDNLLKILQ 224
            :.||.:|:....:.||    :...:.:.|......|.|     :::...|...|         ||
  Fly    18 EHELLELELDYGLAEPQRTSLLQSSLILQFSQDYKHIP-----RITYFTCQKPH---------LQ 68

  Fly   225 QANELKMLGEYQSVFIPLLDTHSIDFGELSGVEANITTVRLMDPSDFHVKNVVHDWEEREKREGR 289
            ..|::....|::..|                ...|...::.:..|:..|:.|:.|...:....||
  Fly    69 TPNQIPNAAEHRDAF----------------AAKNFQLIKSLYESELFVRIVLLDVLAQSPTSGR 117

  Fly   290 ----------YFKVDPNRVKSQMILLNDAVWLFSKGLTELGIFEELTAPDLECRRKKPWPFGKRI 344
                      .|...|::.:|      ::.||  :|:..:....::...||.|     ....:|.
  Fly   118 PNRPGNGPTGGFSQTPSQAQS------NSEWL--EGVLRMEALRQIAVVDLAC-----GAVSRRF 169

  Fly   345 IEFIKAR---SEE--------------TST----GRIDFNE------NGQR-------------S 369
            :|...|:   ||:              |.|    |:.|..|      .||:             |
  Fly   170 LELASAKMLYSEKFHWLLIEDFAWHGRTQTAEGSGKRDDGEMEEEEPPGQQIQATDDEDLPSIES 234

  Fly   370 F-----------FTL--RFME-------------LNSDGFLDL---ATWDPVNGLDVLN------ 399
            |           .||  |..|             ||..|.::|   .::.|..|:.:..
  Fly   235 FLGGMNLYMNTELTLAKRMSEAAHYTLFDVWNPGLNYGGHVNLTEIGSFTPTEGIQLHTWFRTTS 299

  Fly   400 ------DDEESEKRVGQKLSNKTFIVSSRLGAPFLTLREPQEGEILTGNSRYEGYSIDLINEIAK 458
                  |.:.:..|....::||     :..|.....|.....|.|.|.|.    ::.:|:..:..
  Fly   300 TVRRRMDMQHARVRCMVVVTNK-----NMTGTLMYYLTHTMSGHIDTMNR----FNFNLLMAVRD 355

  Fly   459 MLNFKFEFRMSPDGKYGALNKVTQTW--------DGIVRQLIDGNADLGICDLTMTSSRRQAVDF 515
            |.|:.|           .|::.| :|        ||::..||....|:|...:.....|.:.:|.
  Fly   356 MFNWTF-----------VLSRTT-SWGYVKNGRFDGMIGALIRNETDIGGAPIFYWLERHKWIDV 408

  Fly   516 TPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWI-YMGSAYLFISLLLFALA---RMAPDD-- 574
            .....:.....:|..|.:...|...||.||:.|||| .:|...|.:.:|.|...   ::.|.|
  Fly   409 AGRSWSSRPCFIFRHPRSTQKDRIVFLQPFTNDVWILIVGCGVLTVFILWFLTTIEWKLVPHDGS 473

  Fly   575 -------------------------------------------------WENPHP---------- 580
                                                             :|:..|
  Fly   474 ALIKPKGGAPPRHHYQQQQQQEQVEAPVRPITAVSVVVSKEKVEEKQEEYEDSTPIDAGTLWQRC 538

  Fly   581 ------------CKEPEEVENIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMWWFFALMML 633
                        .|:.:..|.:...:.:....:|.:..||........|.|.:......|:..:.
  Fly   539 YQKLNKYIKDRKAKQKKAPERVGLFLESVLFFVGIICQQGLGFSTSFVSGRCIVITSLLFSFCIY 603

  Fly   634 NSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESAS 698
            ..|:|::...|. ..:..:|.:..|| ..|.:|.|.........:|..:......:::....::.
  Fly   604 QFYSASIVGTLL-MEKPKTIKTLSDL-VHSSLKVGMEDILYNRDYFLHTKDPVSMELYAKKITSV 666

  Fly   699 PSVFTKTN----DEGVE----RVQKGKNL---------------------------------YAF 722
            |:  ||.|    ||.|:    .....|:.                                 :||
  Fly   667 PT--TKENEADEDEPVDPNPVSTDPAKSYRDIVHSHETGAHAKDNAASNWLDPETGLLRHLGFAF 729

  Fly   723 ---------LMESTTLEYNVERKCDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLGELGQL 778
                     ::..|..|.::   |||.::..:...|:..| |..|||.||.||..:.::.|.|.|
  Fly   730 HVDVAAAYKIIAETFSEQDI---CDLTEVSMFPPQKTVSI-MQKNSPMRKVISYGLRRVTETGIL 790

  Fly   779 AELKRKWWKEMHGGGNCEKSDEDGGDTPEL--GLENVGGVFLVLGLG-LLSAMVLGCTEFLWN 838
            ......|....   ..|.|..|    |.:|  .::.|....|:|... .::.|:|| ||.|::
  Fly   791 TYHFNVWHSRK---PPCVKKIE----TSDLHVDMDTVSSALLILLFSYAITLMILG-TEILYS 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	55/314 (18%)
		ANF_receptor	39..379	CDD:279440	49/294 (17%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	89/507 (18%)
		Lig_chan	548..812	CDD:278489	64/392 (16%)
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:304360	29/125 (23%)
Ir64a	NP_647962.1	Lig_chan	563..828	CDD:278489	52/279 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462620
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840