DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and gria3b

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_938174.1	Gene:	gria3b / 368416	ZFINID:	ZDB-GENE-030616-53	Length:	883	Species:	Danio rerio

Alignment Length:	860	Identity:	293/860 - (34%)
Similarity:	453/860 - (52%)	Gaps:	61/860 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 SQFMVGSIFTSDKDESEIAFRTAVDRANILERNVELVPIVVYANTD-----DSFIMEKMVCNLIS 82
            :|..:|.:|.....:...|||.||...| ..:|:...|..:..|.|     :||.:....|:..|
Zfish    22 NQINIGGLFMRSTVQEHSAFRFAVQLYN-TNQNMTEKPFHLNYNVDNLESSNSFSVTHAFCSQFS 85

  Fly    83 QGVIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESIPDREHSTMTLNVHPDNLLLSQGLAE 147
            :||.||||.....|.:.:.|.|..|....:      ..|.|........:.:.|.   |...:..
Zfish    86 RGVYAIFGFYDKKSMNTLTSFCGALHTSFV------TPSYPIDSDVQFVIQMRPP---LKGAVLS 141

  Fly   148 IVQSFAWRSFTVVYETDKELQQLQDILQVGEPISNPTTVKQLGPGDDHRPF---LKEIKLSTDNC 209
            ::..:.|..|..:|:||:....||.|::.....:...|.:.:|...|.:.|   ::|:....:..
Zfish   142 LLSHYKWDKFVYLYDTDRGFSILQAIMEAAVANNWQVTARSVGSITDPQEFRRIIEEMDRRQEKR 206

  Fly   210 LILHCAPDNLLKILQQANEL-KMLGEYQSVFIPLLDTH-SIDFGELSGVEANITTVRLMDPSDFH 272
            .::.|..|.:..||:|...| |....|..:...|..|: |:|...|.|  |||:..::::|.:..
Zfish   207 YLIDCEVDRINVILEQVVTLGKNSRGYHYIIANLGFTNISLDKVFLGG--ANISGFQIINPENLV 269

  Fly   273 VKNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDAVWLFSKGLTEL-----GIFEELTAPDLEC 332
            |:..:..|:..::||....|..|  :|....|..||:.:.::....|     .:....:|.|...
Zfish   270 VQQFLQRWDRLDEREFPEAKNTP--LKYTSALSYDAILVIAEAFRYLRRQRVDVSRRGSAGDCLA 332

  Fly   333 RRKKPWPFGKRIIEFIKARSEETSTGRIDFNENGQRSFFTLRFMELNSDGFLDLATWDP----VN 393
            ....||..|..|...:|....:..||.|.|:..|:|:.:|:...|:.:.|...:..|:.    ||
Zfish   333 NPAVPWSQGIDIERALKMVQVQGMTGNIQFDSFGRRTNYTIDVYEMKTGGPRKIGYWNEFERFVN 397

  Fly   394 GLD--VLNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLREPQEGEILTGNSRYEGYSIDLINEI 456
            .:|  ..||....|        |:|.:|::.:.||::..::....  |.||.:||||.:||.:||
Zfish   398 IMDQQFTNDSSSVE--------NRTIVVTTIMEAPYVMYKKNHMH--LEGNEKYEGYCVDLASEI 452

  Fly   457 AKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMT 521
            ||.:..|:...:..||||||.:..|::|:|:|.:|:.|.||:.:..||:|..|.:.:||:.|||:
Zfish   453 AKHVGIKYRLSIVMDGKYGARDPETKSWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMS 517

  Fly   522 LGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDW--ENPHPCKEP 584
            |||||:..||......:||||.|.:.::|:.:..||:.:|::||.::|.:|.:|  :.....|:|
Zfish   518 LGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWQLDETDEVKDP 582

  Fly   585 E---EVENIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMWWFFALMMLNSYTANLAAFLTN 646
            :   :..|.:.|.|:.|.|:|:.|.|||||.|::.|.|:|.|:||||.|::::|||||||||||.
Zfish   583 QTPPDPPNDFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTV 647

  Fly   647 SRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTKTNDEGVE 711
            .|..:.|.||||||.|::|.||.:..|||..|||.|..:.|:|||:.|:||.||||.||..:||.
Zfish   648 ERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFAKTTPDGVA 712

  Fly   712 RVQKGKNLYAFLMESTTLEYNVERK-CDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLGEL 775
            ||:|.|..:|||:|||..||..:|| ||.:::||.||.|.||:|.|..|..|..::.|||||.|.
Zfish   713 RVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNAVNLAVLKLNEQ 777

  Fly   776 GQLAELKRKWWKEMHGGGNCEKSDEDGGD-TPELGLENVGGVFLVL--GLGLLSAMVLGCTEFLW 837
            |.|.:||.|||   :..|.|.....|..| |..|.|.||.|||.:|  ||||  ||::...||.:
Zfish   778 GLLDKLKNKWW---YDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGL--AMMVALIEFCY 837

  Fly   838 NVKSVAIEEKISLKE 852
              ||.|..:::.|::
Zfish   838 --KSRAEAKRLKLEK 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	91/388 (23%)
		ANF_receptor	39..379	CDD:279440	85/354 (24%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	171/378 (45%)
		Lig_chan	548..812	CDD:278489	125/270 (46%)
gria3b	NP_938174.1	Periplasmic_Binding_Protein_Type_1	25..396	CDD:299141	89/384 (23%)
		ANF_receptor	36..379	CDD:279440	85/356 (24%)
		PBP2_iGluR_AMPA	412..794	CDD:270433	173/386 (45%)
		Lig_chan	544..824	CDD:278489	131/282 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591098
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.750