Protein Alignment clumsy and GluRIIB

DIOPT Version :10

• Sequence 1: NP_001036373.1
• Gene: clumsy / 35394
• FlyBaseID: FBgn0026255
• Length: 1002
• Species: Drosophila melanogaster
• Sequence 2: NP_523485.3
• Gene: GluRIIB / 33789
• FlyBaseID: FBgn0020429
• Length: 913
• Species: Drosophila melanogaster
• Alignment Length: 939
• Identity: 330/939 - (35%)
• Similarity: 508/939 - (54%)
• Gaps: 82/939 - (8%)

  Fly     1 MYSLFLTHFLLIALPVLADIDRSQFMVGSIFTSDKDESEIAFRTAVDRANILERNVELVPIVVYA 65
            |:.|.....|.:|:...|:.|.....:|:||...:.:...||..|::..|.:...::|..|..|.
  Fly     1 MHGLQFLVLLALAIASGANEDTLVIKIGAIFFDTEMKLADAFSAALEEVNAINPALKLDAIKRYV 65

  Fly    66 NTDDSFIMEKMVCNLISQGVIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESIPDREHSTM 130
            ..|||.:::.:.|:||..||.||||||:.::|||:..:|:...|||:.:||.|.:|..:|.:..:
  Fly    66 TVDDSIVLQDISCDLIGSGVAAIFGPSSKTNSDIVEVLCNMTGIPHLQFDWHPQQSNRERMNHQL 130

  Fly   131 TLNVHPDNLLLSQGLAEIVQS--FAWRSFTVVYETDKELQQLQDILQVGEPISNPTTVKQLGPGD 193
            |:||.|..|.||...::|:.|  |.|:|||:.||....|.:||.||...:.......:::...||
  Fly   131 TVNVAPMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHILAWKQLHKAGIKMQEFERGD 195

  Fly   194 DHRPFLKEIKLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFGELSGVE- 257
            |:|...|.|..:.:..::|.|..|.|:.::..:....|.|.:..:|:..||||      |||::
  Fly   196 DYRILWKRINNAREKFVLLDCPSDILVDVINASIGYNMTGSFNHLFLTNLDTH------LSGIDG 254

  Fly   258 -------ANITTVRLMDPSDFHVKNVVHDWEEREKREGRYFKVD--PNRVKSQMI-----LLNDA 308
                   ..:..||:..    :|...|||            ::|  .|.|.::..     |:.|:
  Fly   255 FYSRDFTVAVAAVRIRT----YVPPPVHD------------EIDVFDNSVDTRFSSLGSQLVYDS 303

  Fly   309 VWLFSKGLTELGIFEELTAPDLECRRKKPWPFGKRIIEFIKARSEET-----STGRIDFNENGQR 368
            :.||...|.|:........|:..|.|.. |..|.|::|.:|..:.:.     .|.|:..|.:|||
  Fly   304 IVLFYNALLEISQRPGFYIPNFSCGRGF-WQPGPRLVEQMKQITPKMVKPPFKTQRLQINADGQR 367

  Fly   369 SFFTLRFMELNSDGFLDLAT--WDPVNGL-DVLNDDEESEKRVGQK-LSNK--------TFIVSS 421
            ..|.|...    :..:|..|  |:....| |.....|.|.:.:.|| |.||        .:.|::
  Fly   368 EDFNLEVY----NPIIDRVTHIWNKEFQLVDFEKLRENSTQALKQKRLQNKEDFSQKPIRYTVAT 428

  Fly   422 RLGAPFLTLREPQEGEILTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDG 486
            |:|.|:.:.||..||....||.|:|||::|||..:|:...|.|.|....|.|||:.:..|..|||
  Fly   429 RVGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDG 493

  Fly   487 IVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWI 551
            |:|||||.||.:||||||:|.:||..||||.|||.||||||..|.|.|..|:::||:|::.:||:
  Fly   494 IIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYNAEVWL 558

  Fly   552 YMGSAYLFISLLLFALARMAPDDWENP-HPCKEPEEVENIWSIMNTTWLSIGSLMGQGCDILPKA 615
            ::..|.:..:..|....|:...:|:.| .......|.:|||.:.|..||.:||::.||||:||:.
  Fly   559 FVMIAMMITAFALIFTGRIDQYEWDQPVENVNREMERQNIWHLSNALWLVLGSMLNQGCDLLPRG 623

  Fly   616 ASTRLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFR 680
            ...||:|..||.|||::..:|.|.||||:|:|:.|..|.|..||..|:|:::|.:.||:|..:|.
  Fly   624 LPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATSVYFS 688

  Fly   681 DSNFSTYQKMWTAMESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVERKCDLVQIGGW 745
            :||.:..:..|..|.|..|..|||.|:|||:||:..|..||||||:|.|:|.|:|.|:|.|||..
  Fly   689 ESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRNCELTQIGES 753

  Fly   746 LDYKSYGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGG----DTP 806
            ...|.||||:|.|:.:|..:|..:|:|.|.|:|.:|:.||:       |..:|..|..    |..
  Fly   754 FGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWF-------NSNESTCDSNVPTIDDG 811

  Fly   807 ELGLENVGGVFLVLGLGLLSAMVLGCTEFLWNVKSVAIEEKISLKEAFKSEALFAARIWITTKPV 871
            :..:::|||:|:||.:|::..:|:|..||||:|:.::::|||....|.|:|..|..|.|:|.||:
  Fly   812 QFDMDSVGGLFVVLIVGVVVGLVIGVAEFLWHVQRISVKEKIPPMLALKAEFYFVIRFWLTRKPL 876

  Fly   872 HTSSESGSSNS---------SSSSSSRSK 891
            ||..:|..|.|         :|:||::.|
  Fly   877 HTYRQSRDSTSTGYSSLEQITSASSAKKK 905

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	27..397	CDD:380605	112/394 (28%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	167/381 (44%)
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..387	CDD:380605	110/387 (28%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	165/379 (44%)