DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and GluRIIA

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster

Alignment Length:	936	Identity:	371/936 - (39%)
Similarity:	558/936 - (59%)	Gaps:	72/936 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYSLFLTHFLLIALPVLADIDRSQFMVGSIFTSDKDESEIAFRTAVDRANILE-RNVELVPIVVY 64
            :|:..:....|..:..|...||::..||:||..::.|.|::|..|....|.:: ..:..|.|..|
  Fly     8 IYAFIIIIGFLEGIIALGGDDRNEITVGAIFYENEKEIELSFDQAFREVNNMKFSELRFVTIKRY 72

  Fly    65 ANTDDSFIMEKMVCNLISQGVIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESIPDREHST 129
            ..|:|||:::::.|.|||.||.||||||:.::|||:|.|.:...||||.||.....:..::.:..
  Fly    73 MPTNDSFLLQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQLNHQ 137

  Fly   130 MTLNVHPDNLLLSQGLAEIVQS-FAWRSFTVVYETDKELQQLQDILQVGEPISNPTTVKQLGP-G 192
            |::||.|...:||:...||::| :.||:||::|||.:.|.:|||::.:....|:...::.|.. .
  Fly   138 MSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKLRNLADYA 202

  Fly   193 DDHRPFLKEIKLSTDNC-----LILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFGE 252
            ||:|...||    ||..     :||.|.|..|.::|:.:.:.|:.|.:::.|:..||||:....:
  Fly   203 DDYRILWKE----TDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLRD 263

  Fly   253 L--SGVEANITTVRL--MDPSDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQM--ILLNDAVWL 311
            :  ...:||||:|||  :|.:.|            |:::.|..|||.......|  ||:.|||.|
  Fly   264 IYNEDFKANITSVRLKVVDANPF------------ERKKTRLTKVDQILGNQTMLPILIYDAVVL 316

  Fly   312 F-SKGLTELGIFEELTAPDLECRRKKPWPFGKRIIEFIKARSEET-----STGRIDFNENGQRSF 370
            | |.....:...:....|:..|....||..|..|:..:|..||:.     .|..:..:|.|||..
  Fly   317 FASSARNVIAAMQPFHPPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQRIH 381

  Fly   371 FTLRFME--LNSDGFLDLATWDPVNGLD--VLNDDEE--------SEKRVGQKLSNKTFIVSSRL 423
            |.|...:  :|.    .:..|.|.||:.  :||.:.|        ||:|       |.:.|.:..
  Fly   382 FNLEIYKPTVNE----PMMVWTPDNGIKKRLLNLELESAGTTQDFSEQR-------KVYTVVTHY 435

  Fly   424 GAPFLTLREPQEGEILTGNSRYEGYSIDLINEIAKMLNFKFEFR-MSPDGKYGALNKVTQTWDGI 487
            ..|:..::|..|.  ..|..:||||::|||:::::::.|.:||. ::.:|||   |..|:.||||
  Fly   436 EEPYFMMKEDHEN--FRGREKYEGYAVDLISKLSELMEFDYEFMIVNGNGKY---NPETKQWDGI 495

  Fly   488 VRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIY 552
            :|:|||.:|.:|:||||:|..||..||||.|||.||||||..|.|..|.:.|:||.||:::||||
  Fly   496 IRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIY 560

  Fly   553 MGSAYLFISLLLFALARMAPDDWENPHPC-KEPEEVENIWSIMNTTWLSIGSLMGQGCDILPKAA 616
            |..|.|.::|....:||::..:|..|:|. ::|:|:||||::.|:|||.:||:|.|||||||:..
  Fly   561 MIFAQLIMTLAFVFIARLSYREWLPPNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDILPRGP 625

  Fly   617 STRLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRD 681
            ..|::||||||||||||::||||||||||:::..:||.|.:||..|.|:.:|:|.||||..||.:
  Fly   626 HMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTSLFFSE 690

  Fly   682 SNFSTYQKMWTAMESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVERKCDLVQIGGWL 746
            ||.:.||:.|..|:..:||.||.||.|||.||:|.|..||||||:|:|.||:||.|||.|||..:
  Fly   691 SNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERNCDLTQIGEQI 755

  Fly   747 DYKSYGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLE 811
            ..|.||:|:|..|.||..:|.::|:|.|.|:|.::|.||||  :....|:...|..||  ||.:.
  Fly   756 GEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWK--NHNVTCDSYHEVDGD--ELSII 816

  Fly   812 NVGGVFLVLGLGLLSAMVLGCTEFLWNVKSVAIEEKISLKEAFKSEALFAARIWITTKPVHTSSE 876
            .:|||||||..|:|..::||..||||||::||:||:::..:|||:|.:||.:.|:..||:..||.
  Fly   817 ELGGVFLVLAGGVLIGVILGIFEFLWNVQNVAVEERVTPWQAFKAELIFALKFWVRKKPMRISSS 881

  Fly   877 SGSSNSSSSSSSR--SKHSFKSQGLS 900
            |..|:|..||.||  ||...:|:.:|
  Fly   882 SDKSSSRRSSGSRRSSKEKSRSKTVS 907

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	125/391 (32%)
		ANF_receptor	39..379	CDD:279440	115/361 (32%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	184/374 (49%)
		Lig_chan	548..812	CDD:278489	133/264 (50%)
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	124/390 (32%)
		ANF_receptor	46..386	CDD:279440	115/355 (32%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	185/381 (49%)
		Lig_chan	556..828	CDD:278489	140/275 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449683
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16847at50557
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.750