DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and gria4b

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_997917.2	Gene:	gria4b / 336069	ZFINID:	ZDB-GENE-030131-8013	Length:	904	Species:	Danio rerio

Alignment Length:	917	Identity:	311/917 - (33%)
Similarity:	465/917 - (50%)	Gaps:	101/917 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 SQFMVGSIFTSDKDESEIAFRTAV----DRANILERNVELVPIVVYANTDDSFIMEKMVCNLISQ 83
            |...:|.:|..:.|:...|||.|:    ...|..|....|||.|....|.:||.:....|:..|:
Zfish    25 SSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSR 89

  Fly    84 GVIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESIPDREHSTMTLNVHPDNLLLSQGLAEI 148
            ||.||||.....|...:.|.|..|.|..|      ..|.|....|...|.:.|.   :...|..:
Zfish    90 GVFAIFGLYDKRSVHTLTSFCGALHISLI------TPSFPTEGESQFVLQLRPS---IRGALLSL 145

  Fly   149 VQSFAWRSFTVVYETDKELQQLQDIL----QVGEPIS-------NPTTVKQLGPGDDHRPFLKEI 202
            :..:.|..|..:|:||:....||.|:    |.|..:|       |..:.:||         |:::
Zfish   146 LDHYDWNRFVFLYDTDRGYSILQAIMEKAGQNGWQVSAICVENFNDASYRQL---------LEDL 201

  Fly   203 KLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVF---IPLLDTHSIDFGELSGVEANITTVR 264
            ....:...::....:.|..:|:|   :..:|::...:   :..|....|:........||:|..:
Zfish   202 DRRQEKTFVIDLEAERLNNMLEQ---IVSVGKHVKGYHYIMANLGFKDINLERFMHGGANVTGFQ 263

  Fly   265 LMDPSDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDAVWLFSKGLTEL-----GIFEE 324
            |:|.|:..|..::..|.:.::||.......|   |....|..|.|.:.::....|     .|...
Zfish   264 LVDFSNPMVIKLMQRWNKLDQREYPGSDAPP---KYTSALTYDGVMVMAEAFRNLRRQKVDISRR 325

  Fly   325 LTAPDLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNENGQRSFFTLRFMELNSDGFLDLATW 389
            ..|.|.......||..|..:...:|....:..||.:.|:..|:|..:|:...||.|:|...:..|
Zfish   326 GIAGDCLANPAAPWNQGIDMERTLKQVHLQGLTGNVQFDHYGRRVNYTMDVFELKSNGPRRIGYW 390

  Fly   390 DPVNGLDVLNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLREPQEGEILTGNSRYEGYSIDLIN 454
            :..:.| ||..|..........:.|:|.||::.:..|::.|:  :..|:..||.:||||.:||.:
Zfish   391 NDADKL-VLTQDHALLPNETSGMENRTVIVTTIMEGPYVMLK--KNWEMYEGNEQYEGYCVDLAS 452

  Fly   455 EIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPF 519
            ||||.:.||::..:.|||||||.:..|:.|:|:|.:|:.|.|::.:..||:|..|.:.:||:.||
Zfish   453 EIAKHIGFKYKISIVPDGKYGARDPETKIWNGMVGELVYGKAEIAVAPLTITLVREEVIDFSKPF 517

  Fly   520 MTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENPHPCKEP 584
            |:|||||:..||......:||||.|.:.::|:.:..||:.:|::||.::|.:|.:|..    :||
Zfish   518 MSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHT----EEP 578

  Fly   585 EE---------VENIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMWWFFALMMLNSYTANL 640
            ||         ..|.:.|.|:.|.|:|:.|.|||||.|::.|.|:|.|:||||.|::::||||||
Zfish   579 EEGTDGLPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANL 643

  Fly   641 AAFLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTKT 705
            |||||..|..:.|.||||||.|:.|.||.:..|||..|||.|..:.|:|||:.|:||.|:|||||
Zfish   644 AAFLTVERMVSPIESAEDLAKQTDIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPTVFTKT 708

  Fly   706 NDEGVERVQKGKNLYAFLMESTTLEYNVERK-CDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAV 769
            ..|||.||:|.|..||||:|||..||..:|| ||.:::||.||.|.||:|.|..|..|..::.||
Zfish   709 TAEGVARVRKSKGKYAFLLESTMNEYTEQRKPCDTMKVGGNLDSKGYGVATPKGSQLRSAVNLAV 773

  Fly   770 LKLGELGQLAELKRKWWKE-----MHGGGNCEKSDEDGGDTPELGLENVGGVFLVL--GLGLLSA 827
            |||.|.|.|.:||.|||.:     ..|||..:||.:      .|.|.||.|||.:|  ||||  |
Zfish   774 LKLNEQGLLDKLKNKWWYDKGECGSGGGGEKDKSSQ------ALSLSNVAGVFYILVGGLGL--A 830

  Fly   828 MVLGCTEFLWNVKSVAIEEKISLKEAFKSEALFAARIWIT--------------TKPVHTSSESG 878
            |::...||.:..::.|...|::..||.:::    ||:.||              .|.||    ||
Zfish   831 MLVALIEFCYKSRNEAKRMKLTFTEAMRNK----ARLSITGSVGENGRVLTPDCPKAVH----SG 887

  Fly   879 SSNSSSS 885
            .|...||
Zfish   888 PSLRQSS 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	91/392 (23%)
		ANF_receptor	39..379	CDD:279440	84/362 (23%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	177/382 (46%)
		Lig_chan	548..812	CDD:278489	129/278 (46%)
gria4b	NP_997917.2	Periplasmic_Binding_Protein_Type_1	28..398	CDD:324556	92/394 (23%)
		PBP2_iGluR_AMPA_GluR4	414..793	CDD:270445	178/384 (46%)
		Lig_chan	546..827	CDD:306551	135/290 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591042
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.750