DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment clumsy and Grik3

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_001106187.1	Gene:	Grik3 / 298521	RGDID:	71027	Length:	919	Species:	Rattus norvegicus

Alignment Length:	912	Identity:	345/912 - (37%)
Similarity:	514/912 - (56%)	Gaps:	84/912 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VGSIFT-SDKDESEI------AFRTAVDRANILERNVELVPIVVYANT-----------DDSFIM 73
            :|.||. :|...:::      |||.:   |||:.||..|:|     ||           .|||..
  Rat    38 IGGIFEYADGPNAQVMNAEEHAFRFS---ANIINRNRTLLP-----NTTLTYDIQRIHFHDSFEA 94

  Fly    74 EKMVCNLISQGVIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESIPDREHSTMTLNVHPDN 138
            .|..|:.::.||:||||||.||.::.:.|||:.|::|||...|   :..|.....|..:|::||.
  Rat    95 TKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRW---KHHPLDNKDTFYVNLYPDY 156

  Fly   139 LLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEPISNPTTVKQLG-PGDDHRPFLKEI 202
            ..||..:.::|||..|||.||||:....|.:||:::......:....::||. ..||.||.|||:
  Rat   157 ASLSHAILDLVQSLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEM 221

  Fly   203 KLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFG--ELSGVEANITTVRL 265
            |...:..:|..|:.....:||:||..:.|:.||.......||.:::|..  ..|||  |:|..|:
  Rat   222 KRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGV--NLTGFRI 284

  Fly   266 MDPSDFHVKNVVHDWE-EREKREGRYFKVDPNRVKSQMI---------LLNDAVWLFSKGLTELG 320
            ::..:.||..:|..|. ||       .:..| |.:|.::         ||.|||.:.|......
  Rat   285 LNVDNPHVSAIVEKWSMER-------LQAAP-RAESGLLDGVMMTDAALLYDAVHIVSVCYQRA- 340

  Fly   321 IFEELTAPDLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNE-NGQRSFFTLRFMELNSDGFL 384
              .::|...|:|.|.|.|.||.|.:.|||....|..||||.||: :|.|:.|.|..:.|..||..
  Rat   341 --PQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLE 403

  Fly   385 DLATWDPVNGLDVLNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLREPQEGEILTGNSRYEGYS 449
            .:..|.|.:||::....:.....|...|:|::.||::.|..||:..|  :....|.||.|:|||.
  Rat   404 KVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLIVTTLLEEPFVMFR--KSDRTLYGNDRFEGYC 466

  Fly   450 IDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVD 514
            |||:.|:|.:|.|.:|.|:..||||||.:...| |:|:|::|||..|||.:..||:|..|.:|:|
  Rat   467 IDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQ-WNGMVKELIDHKADLAVAPLTITHVREKAID 530

  Fly   515 FTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENPH 579
            |:.||||||:|||:.||......:||||:|.|.|:|:|:..|||.:|.:||.:||.:|.:|.:.|
  Rat   531 FSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAH 595

  Fly   580 PCKEPEE-VENIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMWWFFALMMLNSYTANLAAF 643
            ||....| |||.::::|:.|..:||||.||.:::|||.|||::.|:||||.|::::|||||||||
  Rat   596 PCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAF 660

  Fly   644 LTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTKTNDE 708
            ||..|..:.|:||:|||.|:||:|||:..|:||.||:.|..||::|||..| |:.||...|.|:|
  Rat   661 LTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFM-SSKPSALVKNNEE 724

  Fly   709 GVERVQKGKNLYAFLMESTTLEYNVERKCDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLG 773
            |::|.....  ||.||||||:||..:|.|:|.||||.:|.|.|||..|..||||.:|:.|:|:|.
  Rat   725 GIQRTLTAD--YALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQ 787

  Fly   774 ELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVGGVFLVLGLGLLSAMVLGCTEFLWN 838
            |..:|..:|.|||:    |..|  .:|:..:...||::.:||:|:||..||:.::::...||::.
  Rat   788 EEDKLHIMKEKWWR----GSGC--PEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFIYK 846

  Fly   839 VKSVAIEEKISLKEAFKSEALFA----ARIWITTKP-----------VHTSSESGSSNSSSSSSS 888
            ::..|..|:.|.......|..|:    .|:....:|           :||.::.......|.|.|
  Rat   847 LRKTAEREQRSFCSTVADEIRFSLTCQRRLKHKPQPPMMVKTDAVINMHTFNDRRLPGKDSMSCS 911

  Fly   889 RS 890
            .|
  Rat   912 TS 913

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	131/400 (33%)
		ANF_receptor	39..379	CDD:279440	121/370 (33%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	183/373 (49%)
		Lig_chan	548..812	CDD:278489	126/264 (48%)
Grik3	NP_001106187.1	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	132/402 (33%)
		ANF_receptor	55..398	CDD:279440	121/366 (33%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	183/373 (49%)
		Lig_chan	564..832	CDD:278489	131/276 (47%)
		Glutamate binding	690..692		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349734
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.660