DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and Gria4

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_001106655.1	Gene:	Gria4 / 29629	RGDID:	61863	Length:	902	Species:	Rattus norvegicus

Alignment Length:	901	Identity:	309/901 - (34%)
Similarity:	469/901 - (52%)	Gaps:	87/901 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 SQFMVGSIFTSDKDESEIAFRTAV----DRANILERNVELVPIVVYANTDDSFIMEKMVCNLISQ 83
            |...:|.:|..:.|:...|||.|:    ...|..|....|||.|....|.:||.:....|:..|:
  Rat    25 SSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSR 89

  Fly    84 GVIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESIPDREHSTMTLNVHPDNLLLSQGLAEI 148
            ||.||||.....|...:.|.|..|.|..|      ..|.|....|...|.:.|.   |...|..:
  Rat    90 GVFAIFGLYDKRSVHTLTSFCSALHISLI------TPSFPTEGESQFVLQLRPS---LRGALLSL 145

  Fly   149 VQSFAWRSFTVVYETDKELQQLQDIL----QVGEPIS-------NPTTVKQLGPGDDHRPFLKEI 202
            :..:.|..|..:|:||:....||.|:    |.|..:|       |..:.:||         |:|:
  Rat   146 LDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENFNDVSYRQL---------LEEL 201

  Fly   203 KLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFGELSGVE------ANIT 261
            ....:...::.|..:.|..||:|   :..:|::...:..::  .::.|.::| :|      ||:|
  Rat   202 DRRQEKKFVIDCEIERLQNILEQ---IVSVGKHVKGYHYII--ANLGFKDIS-LERFIHGGANVT 260

  Fly   262 TVRLMDPSDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDAVWLFSKGLTEL-----GI 321
            ..:|:|.:...|..::..|::.::||....:..|   |....|..|.|.:.::....|     .|
  Rat   261 GFQLVDFNTPMVTKLMDRWKKLDQREYPGSETPP---KYTSALTYDGVLVMAETFRSLRRQKIDI 322

  Fly   322 FEELTAPDLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNENGQRSFFTLRFMELNSDGFLDL 386
            .....|.|.......||..|..:...:|....:..||.:.|:..|:|..:|:...||.|.|...:
  Rat   323 SRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKV 387

  Fly   387 ATWDPVNGLDVLNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLREPQEGEILTGNSRYEGYSID 451
            ..|:.::.| ||..|..:.......:.|:|.:|::.:.:|::..:  :..|:..||.:||||.:|
  Rat   388 GYWNDMDKL-VLIQDMPTLGNDTAAIENRTVVVTTIMESPYVMYK--KNHEMFEGNDKYEGYCVD 449

  Fly   452 LINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFT 516
            |.:||||.:..|::..:.|||||||.:..|:.|:|:|.:|:.|.|::.|..||:|..|.:.:||:
  Rat   450 LASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFS 514

  Fly   517 PPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDW--ENPH 579
            .|||:|||||:..||......:||||.|.:.::|:.:..||:.:|::||.::|.:|.:|  |.|.
  Rat   515 KPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPE 579

  Fly   580 PCKE--PEEVENIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMWWFFALMMLNSYTANLAA 642
            ..||  .::..|.:.|.|:.|.|:|:.|.|||||.|::.|.|:|.|:||||.|::::||||||||
  Rat   580 DGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAA 644

  Fly   643 FLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTKTND 707
            |||..|..:.|.||||||.|::|.||.:..|||..|||.|..:.|:||||.|.||.|||||:|..
  Rat   645 FLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTA 709

  Fly   708 EGVERVQKGKNLYAFLMESTTLEYNVERK-CDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLK 771
            |||.||:|.|..:|||:|||..||..:|| ||.:::||.||.|.||:|.|..|..|..::.||||
  Rat   710 EGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRNAVNLAVLK 774

  Fly   772 LGELGQLAELKRKWWKEMHGGGNCEKSDEDGGD-TPELGLENVGGVFLVL--GLGLLSAMVLGCT 833
            |.|.|.|.:||.|||   :..|.|.....|..| |..|.|.||.|||.:|  ||||  ||::...
  Rat   775 LNEQGLLDKLKNKWW---YDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGL--AMLVALI 834

  Fly   834 EFLWNVKSVAIEEKISLKEAFKSEALFAARIWIT--------------TKPVHTSS 875
            ||.:..::.|...|::..||.:::    ||:.||              .|.|||.:
  Rat   835 EFCYKSRAEAKRMKLTFSEAIRNK----ARLSITGSVGENGRVLTPDCPKAVHTGT 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	95/395 (24%)
		ANF_receptor	39..379	CDD:279440	88/365 (24%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	175/377 (46%)
		Lig_chan	548..812	CDD:278489	129/269 (48%)
Gria4	NP_001106655.1	PBP1_iGluR_AMPA_GluR4	28..398	CDD:107383	96/397 (24%)
		ANF_receptor	39..380	CDD:279440	88/367 (24%)
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	177/385 (46%)
		Lig_chan	546..825	CDD:278489	135/281 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349730
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.750