back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and Grik1

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_001104587.1	Gene:	Grik1 / 29559	RGDID:	2732	Length:	949	Species:	Rattus norvegicus

Alignment Length:	984	Identity:	344/984 - (34%)
Similarity:	543/984 - (55%)	Gaps:	119/984 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LTHFLLIALPVLADIDRSQFMVGSIFTSDKDE----SEIAFR---TAVDRANILERNVELVPIVV 63
            |.:||...||   ........:|.||.:.::|    .|:||:   |:::|...|..|..|...:.
  Rat    21 LLYFLCYILP---QTSPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQ 82

  Fly    64 YANTDDSFIMEKMVCNLISQGVIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESIPDREHS 128
            ..|..|||...:..|:.::.||.|:||||..||...:.|||:.|::|||...| .:.|:..|:
  Rat    83 RINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRW-KHPSVDSRD-- 144

  Fly   129 TMTLNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEPISNPTTVKQLGPGD 193
            ...:|::||...:|:.:.::|..:.|::.|||||....|.:||::::.....:....::||.|.:
  Rat   145 LFYINLYPDYAAISRAVLDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPPAN 209

  Fly   194 -DHRPFLKEIKLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFGEL---S 254
             |.:|.|||:|.|.:..:|..|:.:...:||:|...:.|:.||...|...||..::|. ||   |
  Rat   210 KDAKPLLKEMKKSKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDL-ELYRYS 273

  Fly   255 GVEANITTVRLMDPSDFHVKNVVHDWE-EREKREGRYFKVDP------NRVKSQMILLNDAVWLF 312
            ||  |:|..||::..:.||.:::..|. ||.:...|     |      ..:.::..|:.|||::.
  Rat   274 GV--NMTGFRLLNIDNPHVSSIIEKWSMERLQAPPR-----PETGLLDGMMTTEAALMYDAVYMV 331

  Fly   313 SKGLTELGIFEELTAPDLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNE-NGQRSFFTLRFM 376
            :......   .:||...|:|.|.|||..|.|.:..||....:..||||.||: :|.|..|.|..:
  Rat   332 AIASHRA---SQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTGRITFNKTDGLRKDFDLDII 393

  Fly   377 ELNSDG---------------FLDLATWDPVNGLDVLNDDEESEKRVGQKLSNKTFIVSSRLGAP 426
            .|..:|               :..:..|:..:||::.:.:.:....:...|:|:|.||::.|..|
  Rat   394 SLKEEGTEKASGEVSKHLYKVWKKIGIWNSNSGLNMTDGNRDRSNNITDSLANRTLIVTTILEEP 458

  Fly   427 FLTLREPQEGEILTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQL 491
            ::..|:..:.  |.||.|:|||.:||:.|::.:|.|.::.::.|||||||.|...: |:|:|::|
  Rat   459 YVMYRKSDKP--LYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQNDKGE-WNGMVKEL 520

  Fly   492 IDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSA 556
            ||..|||.:..||:|..|.:.:||:.||||||||||:.||......:||||:|.|.|:|:|:..|
  Rat   521 IDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLA 585

  Fly   557 YLFISLLLFALARMAPDDWENPHPCK-EPEEVENIWSIMNTTWLSIGSLMGQGCDILPKAASTRL 620
            .|.:|.:||.:||..|.:|.|||||. :.:.|||.::::|:.|..:|:||.||.:::|||.|||:
  Rat   586 CLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRI 650

  Fly   621 VTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFS 685
            |.|:||||.|::::|||||||||||..|..:.|:||:|||.|:||:|||:..||||.||:.|..|
  Rat   651 VGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKIS 715

  Fly   686 TYQKMWTAMESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVERKCDLVQIGGWLDYKS 750
            ||:|||..|.|...|...|.:|||::||....  ||.|||||::||..:|.|:|.||||.:|.|.
  Rat   716 TYEKMWAFMSSRQQSALVKNSDEGIQRVLTTD--YALLMESTSIEYVTQRNCNLTQIGGLIDSKG 778

  Fly   751 YGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVGG 815
            ||:..|..||||.:|:.|:|:|.|.|:|..:|.|||:    |..|  .:||..:...||:||:||
  Rat   779 YGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWR----GNGC--PEEDSKEASALGVENIGG 837

  Fly   816 VFLVLGLGLLSAMVLGCTEFLW-NVKSVAIEEK---ISLKEAFKSEALFAARIWITTKPVHTSSE 876
            :|:||..||:.::.:...|||: :.|:..:|:|   ..|:..|:::..|
  Rat   838 IFIVLAAGLVLSVFVAIGEFLYKSRKNNDVEQKGKSSRLRFYFRNKVRF---------------- 886

  Fly   877 SGSSNSSSSSSSRSKHSFKSQGLSMKSLKSSGYQDVEASVHSKLKKIGSMFSLKSQKTVTPPPEI 941
                           |..|.:.|.::..         .|.::.::::|  .|||:||
  Rat   887 ---------------HGSKKESLGVEKC---------LSFNAIMEELG--ISLKNQK-------- 917

  Fly   942 GWKLDKSTQ 950
              ||.|.::
  Rat   918 --KLKKKSR 924

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.