DRSC/TRiP Functional Genomics Resources

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Protein Alignment clumsy and GRIN2D

DIOPT Version :9

Sequence 1:NP_001036373.1 Gene:clumsy / 35394 FlyBaseID:FBgn0026255 Length:1002 Species:Drosophila melanogaster
Sequence 2:NP_000827.2 Gene:GRIN2D / 2906 HGNCID:4588 Length:1336 Species:Homo sapiens


Alignment Length:932 Identity:206/932 - (22%)
Similarity:360/932 - (38%) Gaps:240/932 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 VGSIFTSDKDESEIAFRTAVDRANILERNVELVPIVVYANTDDSFIMEKMVCNLIS----QGVIA 87
            |..:|:.....:|.|.......|.:....:::.|:.:..|..|...:...:|:|:|    .||:.
Human    53 VALVFSGPAYAAEAARLGPAVAAAVRSPGLDVRPVALVLNGSDPRSLVLQLCDLLSGLRVHGVVF 117

  Fly    88 IFGPSTGSSSDIIASICDTL----DIPHI-VYDWIPNESIPDREHST-MTLNVHPDNLLLSQGLA 146
                ...|.:..:|.|.|.|    .:|.: |:........|..:.|| :.|....:..|  |.:.
Human   118 ----EDDSRAPAVAPILDFLSAQTSLPIVAVHGGAALVLTPKEKGSTFLQLGSSTEQQL--QVIF 176

  Fly   147 EIVQSFAWRSFTVVYETDKELQQLQDILQVGEPISNPTTVKQLGPGDDHRPFLKEIKLSTDNCLI 211
            |:::.:.|.||..|                       ||   ..||  ||.||..|::.||..|:
Human   177 EVLEEYDWTSFVAV-----------------------TT---RAPG--HRAFLSYIEVLTDGSLV 213

  Fly   212 --------------------------------LHCAPDNLLKILQQANELKMLGEYQSVFIPLLD 244
                                            |.||.:....:.:.|.|..:.|   |.::..:.
Human   214 GWEHRGALTLDPGAGEAVLSAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTG---SGYVWFMV 275

  Fly   245 THSIDFGELSG---------------------------------VEANITTVR------LMD--- 267
            ...:..|..||                                 |.|.:..|.      |.|   
Human   276 GPQLAGGGGSGAPGEPPLLPGGAPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRDYGF 340

  Fly   268 -PS---DFHVKNVVH------------DWEERE---KREGRYFKVDPNRVKSQMILLNDAVWLFS 313
             |.   |...:|..|            .|:.|:   ..:|  |.|:|:.|  .:.|..|..|   
Human   341 LPELGHDCRAQNRTHRGESLHRYFMNITWDNRDYSFNEDG--FLVNPSLV--VISLTRDRTW--- 398

  Fly   314 KGLTELGIFEELTAPDLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNENGQRSFFTLRFMEL 378
               ..:|.:|:.|.       :..:|...|...|::.         :|..::       |....|
Human   399 ---EVVGSWEQQTL-------RLKYPLWSRYGRFLQP---------VDDTQH-------LTVATL 437

  Fly   379 NSDGFLDLATWDPVNGLDVLNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLREPQEGEILTGNS 443
            ....|:.:...||::| ..:.|......::     |:|.  |....||     .|::       .
Human   438 EERPFVIVEPADPISG-TCIRDSVPCRSQL-----NRTH--SPPPDAP-----RPEK-------R 482

  Fly   444 RYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSS 508
            ..:|:.||::..:|..:.|.::..:..:||:|  .|:...|:|::.::....||:.|..||:...
Human   483 CCKGFCIDILKRLAHTIGFSYDLYLVTNGKHG--KKIDGVWNGMIGEVFYQRADMAIGSLTINEE 545

  Fly   509 RRQAVDFTPPFMTLGISILF--SKPPTPPTDLFSFLSPFSLDVWIYMGSAYL-FISLLLFALARM 570
            |.:.|||:.||:..|||::.  |.....|:   :||.|:|..||:.|....| .:::.:|....:
Human   546 RSEIVDFSVPFVETGISVMVARSNGTVSPS---AFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYL 607

  Fly   571 APDDWENPHPC-KEPEEVENIWSIMNTTWLSIGSLMGQGCDI-LPKAASTRLVTGMWWFFALMML 633
            :|..:...... |.|.  .:.::|..:.||....:......: .|:..:::::..:|.|||::.|
Human   608 SPVGYNRSLATGKRPG--GSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFL 670

  Fly   634 NSYTANLAAFLTNSRQANSINSAEDLAAQ------SKIKYGAMAGGSTMGFFRDSNFSTYQKMWT 692
            .|||||||||:......::::...|...|      ..:|:|.:..|||....|    |.|..|.:
Human   671 ASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIR----SNYPDMHS 731

  Fly   693 AM-ESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVERK---CDLVQIGGWLDYKS--Y 751
            .| ....|.|     :|.:.:::.|| |.||:.::..|.| :.||   |.||.||....:.:  |
Human   732 YMVRYNQPRV-----EEALTQLKAGK-LDAFIYDAAVLNY-MARKDEGCKLVTIGSGKVFATTGY 789

  Fly   752 GIAMPFNSPYRKQISAAVLK-LGELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVGG 815
            |||:...|.:::.|..|:|: ||: .::..|:|.|.     .|.|. :|:....:.:|.::|:.|
Human   790 GIALHKGSRWKRPIDLALLQFLGD-DEIEMLERLWL-----SGICH-NDKIEVMSSKLDIDNMAG 847

  Fly   816 VFLVLGLGLLSAMVLGCTEFLW 837
            ||.:    ||.||.|....|.|
Human   848 VFYM----LLVAMGLSLLVFAW 865

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
clumsyNP_001036373.1 PBP1_iGluR_Kainate 26..396 CDD:107377 85/471 (18%)
ANF_receptor 39..379 CDD:279440 78/442 (18%)
PBP2_iGluR_Kainate 414..787 CDD:270432 105/390 (27%)
Lig_chan 548..812 CDD:278489 72/279 (26%)
GRIN2DNP_000827.2 PBP1_iGluR_NMDA_NR2 49..413 CDD:380601 75/413 (18%)
PBP2_iGluR_NMDA_Nr2 430..830 CDD:270436 114/451 (25%)
Glutamate binding. /evidence=ECO:0000250|UniProtKB:Q00959 539..541 0/1 (0%)
Pore-forming. /evidence=ECO:0000250|UniProtKB:Q00960 631..650 2/18 (11%)