Protein Alignment clumsy and GRIN2C

DIOPT Version :9

• Sequence 1: NP_001036373.1
• Gene: clumsy / 35394
• FlyBaseID: FBgn0026255
• Length: 1002
• Species: Drosophila melanogaster
• Sequence 2: XP_016880033.1
• Gene: GRIN2C / 2905
• HGNCID: 4587
• Length: 1337
• Species: Homo sapiens
• Alignment Length: 1124
• Identity: 230/1124 - (20%)
• Similarity: 411/1124 - (36%)
• Gaps: 274/1124 - (24%)

  Fly    24 QFMVGSIFTSDKDESEIAFRTAVDRANILERNVELVPIVVYANTDDSFIMEKMVCNLIS----QG 84
            |.|..::..|.....:..||..:...:.|:..:|:.|:.|..||.:...:...:|.|:.    .|
Human   103 QGMTVAVVFSSSGPPQAQFRARLTPQSFLDLPLEIQPLTVGVNTTNPSSLLTQICGLLGAAHVHG 167

  Fly    85 VIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESIPDREHSTMTLNVHPDNLLLSQG----- 144
            ::......|.:.:.|:..|.....:|.:        ||.......:|.. .|.:..|..|
Human   168 IVFEDNVDTEAVAQILDFISSQTHVPIL--------SISGGSAVVLTPK-EPGSAFLQLGVSLEQ 223

  Fly   145 ----LAEIVQSFAWRSFTVVYETD-------KELQQLQDILQVGEPISNPTTVKQLGPGDDHRPF 198
                |.::::.:.|.:|.|:....       :.::.:.|...|...:.:..|: :||||......
Human   224 QLQVLFKVLEEYDWSAFAVITSLHPGHALFLEGVRAVADASHVSWRLLDVVTL-ELGPGGPRART 287

  Fly   199 LKEIKLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFGELSGVEANITTV 263
            .:.::.......:.:|:.:....:..:|.:..::|......:|.|...|.|
Human   288 QRLLRQLDAPVFVAYCSREEAEVLFAEAAQAGLVGPGHVWLVPNLALGSTD-------------- 338

  Fly   264 RLMDPSDFHV---KNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDAVWLFSKGL----TELGI 321
              ..|:.|.|   ..|...|....:::.|                 |.|.:.:.|.    .:.|
Human   339 --APPATFPVGLISVVTESWRLSLRQKVR-----------------DGVAILALGAHSYWRQHG- 383

  Fly   322 FEELTAPDLECRRKKPWPFGKRIIEFIKARSEETSTGR-IDFNENGQRSFFTLRFMELNSDGFLD 385
              .|.||..:| |..|.|.......|.:.....|..|| ..|:..|.....|:..:.||..
Human   384 --TLPAPAGDC-RVHPGPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVQPTMVVIALNRH---- 441

  Fly   386 LATWDPVNGLD--VLNDDEESEKRVGQKL----SNKTFIVSSRLGAPFLTLREPQEGEILTG--- 441
             ..|:.|...:  ||........|....|    .::...|::....||:.:..|..|   ||
Human   442 -RLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESPDPG---TGGCV 502

  Fly   442 ----------NSRY-------------EGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQT 483
                      |..:             :|:.||::.::|:::.|.::..:..:||:|  .:|...
Human   503 PNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVTNGKHG--KRVRGV 565

  Fly   484 WDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILF--SKPPTPPTDLFSFLSPFS 546
            |:|::.::....||:.|..||:...|.:.|||:.||:..|||::.  |.....|:   :||.|:|
Human   566 WNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPS---AFLEPYS 627

  Fly   547 LDVWIYMGSAYL-FISLLLFALARMAPDDWENPHPCKEPEEVENIWSIMNTTWLSIGSLMGQGCD 610
            ..||:.|....| .:::.:|.....:|..: |.:..:..:.....::|..:.||....:......
Human   628 PAVWVMMFVMCLTVVAITVFMFEYFSPVSY-NQNLTRGKKSGGPAFTIGKSVWLLWALVFNNSVP 691

  Fly   611 I-LPKAASTRLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAA------------- 661
            | .|:..:::::..:|.|||::.|.|||||||||:...:..::::...|..:
Human   692 IENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKSLHLENTGVAWTAF 756

  Fly   662 --------------QSKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTKTNDEGVE- 711
                          ....::|.:..|||....|    |.|:.|.|.|        .|.|...||
Human   757 KTFCSDYFQRPQDQYPPFRFGTVPNGSTERNIR----SNYRDMHTHM--------VKFNQRSVED 809

  Fly   712 ---RVQKG-------KNLYAFLMESTTLEY--NVERKCDLVQIGGWLDYKS--YGIAMPFNSPYR 762
               .::.|       :.|.||:.::..|.|  ..:..|.||.||....:.:  |||||..:|.::
Human   810 ALTSLKMGSEAQPVPRKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWK 874

  Fly   763 KQISAAVLK-LGELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVGGVFLVLGLGLLS 826
            :.|..|:|: ||: |:..:|:..|.     .|.|: ::::...:.:|.::|:.|||.:    ||.
Human   875 RAIDLALLQFLGD-GETQKLETVWL-----SGICQ-NEKNEVMSSKLDIDNMAGVFYM----LLV 928

  Fly   827 AMVLGCTEFLW---------------------------------NVKSVAIEEKISLKEAFKSEA 858
            ||.|....|.|                                 .|:|:|...:.:..:...|.|
Human   929 AMGLALLVFAWEHLVYWKLRHSVPNSSQLDFLLAFSRGIYSCFSGVQSLASPPRQASPDLTASSA 993

  Fly   859 -------LFAARIWITTKPVHTSSESGSSNSSSSSSSRSKHSFKSQGLSMKSLKSSGYQDVEASV 916
                   |.|||..:||..|            |||..|:..:.::.|...::...|......:..
Human   994 QASVLKMLQAARDMVTTAGV------------SSSLDRATRTIENWGGGRRAPPPSPCPTPRSGP 1046

  Fly   917 HSKLKKIGSMFSLKSQKTVTPPPE---IGWKLDKSTQIDVV---------------PTSDVDQ-E 962
            ...|            .|..||||   .||......:..:|               |.|||.: .
Human  1047 SPCL------------PTPDPPPEPSPTGWGPPDGGRAALVRRAPQPPGRPPTPGPPLSDVSRVS 1099

  Fly   963 LIPEVEPHLPHRHHHHHHH 981
            ..|..|...|.|..|...|
Human  1100 RRPAWEARWPVRTGHCGRH 1118

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	69/397 (17%)
		ANF_receptor	39..379	CDD:279440	63/367 (17%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	105/445 (24%)
		Lig_chan	548..812	CDD:278489	69/308 (22%)
GRIN2C	XP_016880033.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155832
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740