Protein Alignment clumsy and GRIN2B

DIOPT Version :10

• Sequence 1: NP_001036373.1
• Gene: clumsy / 35394
• FlyBaseID: FBgn0026255
• Length: 1002
• Species: Drosophila melanogaster
• Sequence 2: NP_000825.2
• Gene: GRIN2B / 2904
• HGNCID: 4586
• Length: 1484
• Species: Homo sapiens
• Alignment Length: 1116
• Identity: 249/1116 - (22%)
• Similarity: 442/1116 - (39%)
• Gaps: 279/1116 - (25%)

  Fly    10 LLIALPVLADIDRSQ----------FMVGSIFTSDKDESEIAFRTAVDRANILERNVELVP---I 61
            :|..|.|.....|||          .:||   |||    |:|.:.|.::.:.  .::.:||   :
Human    15 VLAVLAVSGSRARSQKSPPSIGIAVILVG---TSD----EVAIKDAHEKDDF--HHLSVVPRVEL 70

  Fly    62 VVYANTDDSFIMEKMVCNLIS----QGVIAIFGPSTGSSSDIIASICDTLD----IPHIVYDWIP 118
            |....||...|:.: :|:|:|    |||  :|...|  ..:.||.|.|.:.    .|.:......
Human    71 VAMNETDPKSIITR-ICDLMSDRKIQGV--VFADDT--DQEAIAQILDFISAQTLTPILGIHGGS 130

  Fly   119 NESIPDREHSTMTLNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDIL-QVGEPISN 182
            :..:.|::.|:|.....|.....:..:..|::.:.|..|::|   .......||.: ::...|.|
Human   131 SMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIV---TTYFPGYQDFVNKIRSTIEN 192

  Fly   183 --------PTTVKQLGPGDDHRPFLKEIKLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVF 239
                    ...:..:...|.......::|......::|:|..:....|.:.||.:.:.|...:..
Human   193 SFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWI 257

  Fly   240 IPLLDTHSIDFGELSGVEANITTVRLMDPSDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMIL 304
            :|.|            |..:..||    |::|....:...::|.:...       |.||:..:.:
Human   258 VPSL------------VAGDTDTV----PAEFPTGLISVSYDEWDYGL-------PARVRDGIAI 299

  Fly   305 LNDAVWLFSKGLTELGIFEELTAPDLECRRKKPWPFGKRIIE---FIKARSEETSTGR-IDFNEN 365
            :..|.   |..|:|.....|   |...|.....    |||.:   ..:.....|..|| :.|:|:
Human   300 ITTAA---SDMLSEHSFIPE---PKSSCYNTHE----KRIYQSNMLNRYLINVTFEGRNLSFSED 354

  Fly   366 GQRSFFTLRFMELNSDGFLDLATWDPVNGLDVLNDDE-------------ESEKRVGQKLSNKTF 417
            |.:....|..:.||.:     ..|:.|.   ...|..             |:|::....||
Human   355 GYQMHPKLVIILLNKE-----RKWERVG---KWKDKSLQMKYYVWPRMCPETEEQEDDHLS---- 407

  Fly   418 IVSSRLGAPFLTLRE-------------PQEGEILTGNSRYE----------GYSIDLINEIAKM 459
            ||:.. .|||:.:..             |.:..|:|.|...|          |:.||::.:|:|.
Human   408 IVTLE-EAPFVIVESVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKS 471

  Fly   460 LNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGI 524
            :.|.::..:..:||:|  .|:..||:|::.:::...|.:.:..||:...|.:.|||:.||:..||
Human   472 VKFTYDLYLVTNGKHG--KKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGI 534

  Fly   525 SILFSKP--PTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENP---HPC--- 581
            |::.|:.  ...|:   :||.|||.|||:.|     |:.||:.:...:...::.:|   :.|
Human   535 SVMVSRSNGTVSPS---AFLEPFSADVWVMM-----FVMLLIVSAVAVFVFEYFSPVGYNRCLAD 591

  Fly   582 -KEPEEVENIWSIMNTTWLSIGSLMGQGCDIL-PKAASTRLVTGMWWFFALMMLNSYTANLAAFL 644
             :||....  ::|....||..|.:......:. ||..:::::..:|.|||::.|.|||||||||:
Human   592 GREPGGPS--FTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFM 654

  Fly   645 TNSRQANSINSAEDLAAQ------SKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFT 703
            ......:.::...|...|      ...::|.:..|||....|::    |.:|...|        .
Human   655 IQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNN----YAEMHAYM--------G 707

  Fly   704 KTNDEGVE----RVQKGKNLYAFLMESTTLEYNVERK--CDLVQIGGWLDYKS--YGIAMPFNSP 760
            |.|..||:    .::.|| |.||:.::..|.|...|.  |.||.||....:.|  ||||:..:|.
Human   708 KFNQRGVDDALLSLKTGK-LDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSG 771

  Fly   761 YRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVGGVFLVLGLGL- 824
            :::|:..|:|:|...|::.||:..|..     |.|. ::::...:.:|.::|:.|||.:||..:
Human   772 WKRQVDLAILQLFGDGEMEELEALWLT-----GICH-NEKNEVMSSQLDIDNMAGVFYMLGAAMA 830

  Fly   825 LSAMVLGCTE-FLWN--------------------------VKSVAIEEKISLKEAFKSEALFAA 862
            ||.:...|.. |.|.                          :..|||||:.|:
Human   831 LSLITFICEHLFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSV------------ 883

  Fly   863 RIWITTKPVHTSSESGSSNSSSSSSSRSKHSFKSQGLSMKSLKSSGYQDVEASVHSKLKKIGSMF 927
                      .:|.:.:.|::.|:..|...:.|    :|.:|  ||......|....:::..|::
Human   884 ----------MNSPTATMNNTHSNILRLLRTAK----NMANL--SGVNGSPQSALDFIRRESSVY 932

  Fly   928 SLKSQKTV----------TPPPEIGWKLDKSTQIDVVPTSDVDQELIPEVEPHL---------PH 973
            .:...:..          .||.|                .::..:.|.|||...         .:
Human   933 DISEHRRSFTHSDCKSYNNPPCE----------------ENLFSDYISEVERTFGNLQLKDSNVY 981

  Fly   974 RHHHHHHHRHH 984
            :.|:|||||.|
Human   982 QDHYHHHHRPH 992

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	27..397	CDD:380605	79/393 (20%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	114/419 (27%)
GRIN2B	NP_000825.2	PBP1_iGluR_NMDA_NR2	33..388	CDD:380601	80/412 (19%)
		PBP2_iGluR_NMDA_Nr2	403..803	CDD:270436	118/435 (27%)
		Pore-forming. /evidence=ECO:0000250|UniProtKB:A7XY94	604..623		3/18 (17%)
		NMDAR2_C	840..1484	CDD:463148	33/197 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1074..1097
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1161..1194
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1271..1301
		Interaction with DAPK1. /evidence=ECO:0000250|UniProtKB:Q01097	1292..1304
		PDZ-binding. /evidence=ECO:0000250	1482..1484