DRSC/TRiP Functional Genomics Resources

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Protein Alignment clumsy and GRIN2B

DIOPT Version :9

Sequence 1:NP_001036373.1 Gene:clumsy / 35394 FlyBaseID:FBgn0026255 Length:1002 Species:Drosophila melanogaster
Sequence 2:NP_000825.2 Gene:GRIN2B / 2904 HGNCID:4586 Length:1484 Species:Homo sapiens


Alignment Length:1116 Identity:249/1116 - (22%)
Similarity:442/1116 - (39%) Gaps:279/1116 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 LLIALPVLADIDRSQ----------FMVGSIFTSDKDESEIAFRTAVDRANILERNVELVP---I 61
            :|..|.|.....|||          .:||   |||    |:|.:.|.::.:.  .::.:||   :
Human    15 VLAVLAVSGSRARSQKSPPSIGIAVILVG---TSD----EVAIKDAHEKDDF--HHLSVVPRVEL 70

  Fly    62 VVYANTDDSFIMEKMVCNLIS----QGVIAIFGPSTGSSSDIIASICDTLD----IPHIVYDWIP 118
            |....||...|:.: :|:|:|    |||  :|...|  ..:.||.|.|.:.    .|.:......
Human    71 VAMNETDPKSIITR-ICDLMSDRKIQGV--VFADDT--DQEAIAQILDFISAQTLTPILGIHGGS 130

  Fly   119 NESIPDREHSTMTLNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDIL-QVGEPISN 182
            :..:.|::.|:|.....|.....:..:..|::.:.|..|::|   .......||.: ::...|.|
Human   131 SMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIV---TTYFPGYQDFVNKIRSTIEN 192

  Fly   183 --------PTTVKQLGPGDDHRPFLKEIKLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVF 239
                    ...:..:...|.......::|......::|:|..:....|.:.||.:.:.|...:..
Human   193 SFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWI 257

  Fly   240 IPLLDTHSIDFGELSGVEANITTVRLMDPSDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMIL 304
            :|.|            |..:..||    |::|....:...::|.:...       |.||:..:.:
Human   258 VPSL------------VAGDTDTV----PAEFPTGLISVSYDEWDYGL-------PARVRDGIAI 299

  Fly   305 LNDAVWLFSKGLTELGIFEELTAPDLECRRKKPWPFGKRIIE---FIKARSEETSTGR-IDFNEN 365
            :..|.   |..|:|.....|   |...|.....    |||.:   ..:.....|..|| :.|:|:
Human   300 ITTAA---SDMLSEHSFIPE---PKSSCYNTHE----KRIYQSNMLNRYLINVTFEGRNLSFSED 354

  Fly   366 GQRSFFTLRFMELNSDGFLDLATWDPVNGLDVLNDDE-------------ESEKRVGQKLSNKTF 417
            |.:....|..:.||.:     ..|:.|.   ...|..             |:|::....||    
Human   355 GYQMHPKLVIILLNKE-----RKWERVG---KWKDKSLQMKYYVWPRMCPETEEQEDDHLS---- 407

  Fly   418 IVSSRLGAPFLTLRE-------------PQEGEILTGNSRYE----------GYSIDLINEIAKM 459
            ||:.. .|||:.:..             |.:..|:|.|...|          |:.||::.:|:|.
Human   408 IVTLE-EAPFVIVESVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKS 471

  Fly   460 LNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGI 524
            :.|.::..:..:||:|  .|:..||:|::.:::...|.:.:..||:...|.:.|||:.||:..||
Human   472 VKFTYDLYLVTNGKHG--KKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGI 534

  Fly   525 SILFSKP--PTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENP---HPC--- 581
            |::.|:.  ...|:   :||.|||.|||:.|     |:.||:.:...:...::.:|   :.|   
Human   535 SVMVSRSNGTVSPS---AFLEPFSADVWVMM-----FVMLLIVSAVAVFVFEYFSPVGYNRCLAD 591

  Fly   582 -KEPEEVENIWSIMNTTWLSIGSLMGQGCDIL-PKAASTRLVTGMWWFFALMMLNSYTANLAAFL 644
             :||....  ::|....||..|.:......:. ||..:::::..:|.|||::.|.|||||||||:
Human   592 GREPGGPS--FTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFM 654

  Fly   645 TNSRQANSINSAEDLAAQ------SKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFT 703
            ......:.::...|...|      ...::|.:..|||....|::    |.:|...|        .
Human   655 IQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNN----YAEMHAYM--------G 707

  Fly   704 KTNDEGVE----RVQKGKNLYAFLMESTTLEYNVERK--CDLVQIGGWLDYKS--YGIAMPFNSP 760
            |.|..||:    .::.|| |.||:.::..|.|...|.  |.||.||....:.|  ||||:..:|.
Human   708 KFNQRGVDDALLSLKTGK-LDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSG 771

  Fly   761 YRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVGGVFLVLGLGL- 824
            :::|:..|:|:|...|::.||:..|..     |.|. ::::...:.:|.::|:.|||.:||..: 
Human   772 WKRQVDLAILQLFGDGEMEELEALWLT-----GICH-NEKNEVMSSQLDIDNMAGVFYMLGAAMA 830

  Fly   825 LSAMVLGCTE-FLWN--------------------------VKSVAIEEKISLKEAFKSEALFAA 862
            ||.:...|.. |.|.                          :..|||||:.|:            
Human   831 LSLITFICEHLFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSV------------ 883

  Fly   863 RIWITTKPVHTSSESGSSNSSSSSSSRSKHSFKSQGLSMKSLKSSGYQDVEASVHSKLKKIGSMF 927
                      .:|.:.:.|::.|:..|...:.|    :|.:|  ||......|....:::..|::
Human   884 ----------MNSPTATMNNTHSNILRLLRTAK----NMANL--SGVNGSPQSALDFIRRESSVY 932

  Fly   928 SLKSQKTV----------TPPPEIGWKLDKSTQIDVVPTSDVDQELIPEVEPHL---------PH 973
            .:...:..          .||.|                .::..:.|.|||...         .:
Human   933 DISEHRRSFTHSDCKSYNNPPCE----------------ENLFSDYISEVERTFGNLQLKDSNVY 981

  Fly   974 RHHHHHHHRHH 984
            :.|:|||||.|
Human   982 QDHYHHHHRPH 992

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
clumsyNP_001036373.1 PBP1_iGluR_Kainate 26..396 CDD:107377 79/393 (20%)
ANF_receptor 39..379 CDD:279440 70/363 (19%)
PBP2_iGluR_Kainate 414..787 CDD:270432 114/419 (27%)
Lig_chan 548..812 CDD:278489 75/285 (26%)
GRIN2BNP_000825.2 PBP1_iGluR_NMDA_NR2 33..393 CDD:107373 80/417 (19%)
PBP2_iGluR_NMDA_Nr2 403..803 CDD:270436 118/435 (27%)
HisJ <459..>542 CDD:223904 26/84 (31%)
Lig_chan 557..829 CDD:278489 81/297 (27%)
Pore-forming. /evidence=ECO:0000250|UniProtKB:A7XY94 604..623 3/18 (17%)