Protein Alignment clumsy and GRIK5

DIOPT Version :10

• Sequence 1: NP_001036373.1
• Gene: clumsy / 35394
• FlyBaseID: FBgn0026255
• Length: 1002
• Species: Drosophila melanogaster
• Sequence 2: XP_011525167.1
• Gene: GRIK5 / 2901
• HGNCID: 4583
• Length: 982
• Species: Homo sapiens
• Alignment Length: 911
• Identity: 309/911 - (33%)
• Similarity: 488/911 - (53%)
• Gaps: 96/911 - (10%)

  Fly    64 YANTDDSFIMEKMVCNLISQGVIAIFGPSTG-SSSDIIASICDTLDIPHIVYDWIPNESIPDREH 127
            |..||       .:|.::.:||:::.|||:. :|:..::.||...:||||.   :..|..|..::
Human    76 YETTD-------TMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIK---VGPEETPRLQY 130

  Fly   128 STM-TLNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEPISNPT-TVKQLG 190
            ... :::::|.|..:|..::.|::||.:.|.:::....:.|.:|::::: |..||..| :|:.|.
Human   131 LRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVR-GFLISKETLSVRMLD 194

  Fly   191 PGDDHRPFLKEI---KLST----DNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSI 248
            ...|..|.||||   |:||    .|..|.|.       ||::|:||.|...:....:..:|...:
Human   195 DSRDPTPLLKEIRDDKVSTIIIDANASISHL-------ILRKASELGMTSAFYKYILTTMDFPIL 252

  Fly   249 DFGELSGVEANITTVRLMDPS-----DFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDA 308
            ....:....:||....:.:.|     :| |:::...|  ||..|...: :.|   .....|:.||
Human   253 HLDGIVEDSSNILGFSMFNTSHPFYPEF-VRSLNMSW--RENCEASTY-LGP---ALSAALMFDA 310

  Fly   309 VWLFSKGLTELGIFEELTAPDLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNENGQRSFFTL 373
            |.:....:.||...:|:....|.|.....||.|..::.:::....:..|||::||..|||:.:||
Human   311 VHVVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTL 375

  Fly   374 RFMELNSDGFLDLATWDP-------VNGLDVLNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLR 431
            |.:|.:..|..::..|..       ...||:         .:.|.|:|||.:|::.|..|:: :|
Human   376 RILEKSRQGHREIGVWYSNRTLAMNATTLDI---------NLSQTLANKTLVVTTILENPYV-MR 430

  Fly   432 EPQEGEILTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLID-GN 495
            .| ..:.|:||.|:||:.:|::.|:|::|.|::..|:..||.||| .:...:|.|:|.:||: ..
Human   431 RP-NFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGA-PEPNGSWTGMVGELINRQK 493

  Fly   496 ADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFI 560
            |||.:...|:|:.|.:.:||:.||||||||||:..........||||.|||..||::|..|||.:
Human   494 ADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAV 558

  Fly   561 SLLLFALARMAPDDWENPHPC--KEPEEVENIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTG 623
            |.:||..||::|.:|.|||||  ..|..:||.:::.|:.|..:|..|.||.:|:|:|.|||.|:|
Human   559 SCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSG 623

  Fly   624 MWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQ 688
            :||.|.|::::|||||||||||..|....:.||:|||.|:.|:||.:..||||.||::|.:.|||
Human   624 VWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQ 688

  Fly   689 KMWTAMESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVERKCDLVQIGGWLDYKSYGI 753
            :||..|:|..||||.|:.:||:.||...:  ||||:|||..||:....|:|.||||.||.|.|||
Human   689 RMWNYMQSKQPSVFVKSTEEGIARVLNSR--YAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGI 751

  Fly   754 AMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVGGVFL 818
            .||..||:|.:|:.|:|:|.|..:|..||||||:    ||.|.|  |:......||:||:||:|:
Human   752 GMPLGSPFRDEITLAILQLQENNRLEILKRKWWE----GGRCPK--EEDHRAKGLGMENIGGIFI 810

  Fly   819 VLGLGLLSAMVLGCTEFLWNVKSVAIEEKISLKEAFKSEALFAARIWITTKPVHTSSESGSSNSS 883
            ||..||:.|:.:...||:|:.:..|        |:.::.||..|....:.....|..:..|....
Human   811 VLICGLIIAVFVAVMEFIWSTRRSA--------ESEETPALHPAACQCSALGPRTPLKEPSMLLV 867

  Fly   884 SSSSSRSKHSFKSQGL----------SMKSLKSSGYQDVEASVHSKLKKIGSMFSLKSQKTVTPP 938
            ...|:|.:.:|....|          .:.||......:|:...|        ..|||....:|.|
Human   868 KVPSTRVQVAFSRTSLRQVCPFLLQHQLSSLYWIQATNVQICCH--------FSSLKPSPDLTFP 924

  Fly   939 P 939
            |
Human   925 P 925

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	27..397	CDD:380605	89/354 (25%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	175/375 (47%)
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	88/349 (25%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:473866	175/375 (47%)