DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and GRIK5

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	XP_011525167.1	Gene:	GRIK5 / 2901	HGNCID:	4583	Length:	982	Species:	Homo sapiens

Alignment Length:	911	Identity:	309/911 - (33%)
Similarity:	488/911 - (53%)	Gaps:	96/911 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 YANTDDSFIMEKMVCNLISQGVIAIFGPSTG-SSSDIIASICDTLDIPHIVYDWIPNESIPDREH 127
            |..||       .:|.::.:||:::.|||:. :|:..::.||...:||||.   :..|..|..::
Human    76 YETTD-------TMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIK---VGPEETPRLQY 130

  Fly   128 STM-TLNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEPISNPT-TVKQLG 190
            ... :::::|.|..:|..::.|::||.:.|.:::....:.|.:|::::: |..||..| :|:.|.
Human   131 LRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVR-GFLISKETLSVRMLD 194

  Fly   191 PGDDHRPFLKEI---KLST----DNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSI 248
            ...|..|.||||   |:||    .|..|.|.       ||::|:||.|...:....:..:|...:
Human   195 DSRDPTPLLKEIRDDKVSTIIIDANASISHL-------ILRKASELGMTSAFYKYILTTMDFPIL 252

  Fly   249 DFGELSGVEANITTVRLMDPS-----DFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDA 308
            ....:....:||....:.:.|     :| |:::...|  ||..|...: :.|   .....|:.||
Human   253 HLDGIVEDSSNILGFSMFNTSHPFYPEF-VRSLNMSW--RENCEASTY-LGP---ALSAALMFDA 310

  Fly   309 VWLFSKGLTELGIFEELTAPDLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNENGQRSFFTL 373
            |.:....:.||...:|:....|.|.....||.|..::.:::....:..|||::||..|||:.:||
Human   311 VHVVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTL 375

  Fly   374 RFMELNSDGFLDLATWDP-------VNGLDVLNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLR 431
            |.:|.:..|..::..|..       ...||:         .:.|.|:|||.:|::.|..|:: :|
Human   376 RILEKSRQGHREIGVWYSNRTLAMNATTLDI---------NLSQTLANKTLVVTTILENPYV-MR 430

  Fly   432 EPQEGEILTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLID-GN 495
            .| ..:.|:||.|:||:.:|::.|:|::|.|::..|:..||.||| .:...:|.|:|.:||: ..
Human   431 RP-NFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGA-PEPNGSWTGMVGELINRQK 493

  Fly   496 ADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFI 560
            |||.:...|:|:.|.:.:||:.||||||||||:..........||||.|||..||::|..|||.:
Human   494 ADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAV 558

  Fly   561 SLLLFALARMAPDDWENPHPC--KEPEEVENIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTG 623
            |.:||..||::|.:|.|||||  ..|..:||.:::.|:.|..:|..|.||.:|:|:|.|||.|:|
Human   559 SCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSG 623

  Fly   624 MWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQ 688
            :||.|.|::::|||||||||||..|....:.||:|||.|:.|:||.:..||||.||::|.:.|||
Human   624 VWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQ 688

  Fly   689 KMWTAMESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVERKCDLVQIGGWLDYKSYGI 753
            :||..|:|..||||.|:.:||:.||...:  ||||:|||..||:....|:|.||||.||.|.|||
Human   689 RMWNYMQSKQPSVFVKSTEEGIARVLNSR--YAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGI 751

  Fly   754 AMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVGGVFL 818
            .||..||:|.:|:.|:|:|.|..:|..||||||:    ||.|.|  |:......||:||:||:|:
Human   752 GMPLGSPFRDEITLAILQLQENNRLEILKRKWWE----GGRCPK--EEDHRAKGLGMENIGGIFI 810

  Fly   819 VLGLGLLSAMVLGCTEFLWNVKSVAIEEKISLKEAFKSEALFAARIWITTKPVHTSSESGSSNSS 883
            ||..||:.|:.:...||:|:.:..|        |:.::.||..|....:.....|..:..|....
Human   811 VLICGLIIAVFVAVMEFIWSTRRSA--------ESEETPALHPAACQCSALGPRTPLKEPSMLLV 867

  Fly   884 SSSSSRSKHSFKSQGL----------SMKSLKSSGYQDVEASVHSKLKKIGSMFSLKSQKTVTPP 938
            ...|:|.:.:|....|          .:.||......:|:...|        ..|||....:|.|
Human   868 KVPSTRVQVAFSRTSLRQVCPFLLQHQLSSLYWIQATNVQICCH--------FSSLKPSPDLTFP 924

  Fly   939 P 939
            |
Human   925 P 925

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	88/353 (25%)
		ANF_receptor	39..379	CDD:279440	86/329 (26%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	175/375 (47%)
		Lig_chan	548..812	CDD:278489	128/265 (48%)
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	25..399	CDD:107389	88/347 (25%)
		ANF_receptor	42..379	CDD:279440	85/327 (26%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:304360	175/375 (47%)
		Lig_chan	546..816	CDD:278489	135/277 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155844
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.760