DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment clumsy and GRIK3

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_000822.2	Gene:	GRIK3 / 2899	HGNCID:	4581	Length:	919	Species:	Homo sapiens

Alignment Length:	868	Identity:	336/868 - (38%)
Similarity:	500/868 - (57%)	Gaps:	69/868 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VGSIFT-SDKDESEI------AFRTAVDRANILERNVELVPIVVYANT-----------DDSFIM 73
            :|.||. :|...:::      |||.:   |||:.||..|:|     ||           .|||..
Human    38 IGGIFEYADGPNAQVMNAEEHAFRFS---ANIINRNRTLLP-----NTTLTYDIQRIHFHDSFEA 94

  Fly    74 EKMVCNLISQGVIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESIPDREHSTMTLNVHPDN 138
            .|..|:.::.||:||||||.||.::.:.|||:.|::|||...|   :..|.....|..:|::||.
Human    95 TKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRW---KHHPLDNKDTFYVNLYPDY 156

  Fly   139 LLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEPISNPTTVKQLG-PGDDHRPFLKEI 202
            ..||..:.::||...|||.||||:....|.:||:::......:....::||. ..||.||.|||:
Human   157 ASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEM 221

  Fly   203 KLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFG--ELSGVEANITTVRL 265
            |...:..:|..|:.....:||:||..:.|:.||.......||.:::|..  ..|||  |:|..|:
Human   222 KRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGV--NLTGFRI 284

  Fly   266 MDPSDFHVKNVVHDWE-EREKREGRYFKVDPNRVKSQMI---------LLNDAVWLFSKGLTELG 320
            ::..:.||..:|..|. ||       .:..| |.:|.::         ||.|||.:.|......
Human   285 LNVDNPHVSAIVEKWSMER-------LQAAP-RSESGLLDGVMMTDAALLYDAVHIVSVCYQRA- 340

  Fly   321 IFEELTAPDLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNE-NGQRSFFTLRFMELNSDGFL 384
              .::|...|:|.|.|.|.||.|.:.|||....|..||||.||: :|.|:.|.|..:.|..||..
Human   341 --PQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLE 403

  Fly   385 DLATWDPVNGLDVLNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLREPQEGEILTGNSRYEGYS 449
            .:..|.|.:||::....:.....|...|:|::.||::.|..||:..|  :....|.||.|:|||.
Human   404 KVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFR--KSDRTLYGNDRFEGYC 466

  Fly   450 IDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVD 514
            |||:.|:|.:|.|.:|.|:..||||||.:...| |:|:|::|||..|||.:..||:|..|.:|:|
Human   467 IDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQ-WNGMVKELIDHKADLAVAPLTITHVREKAID 530

  Fly   515 FTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENPH 579
            |:.||||||:|||:.||......:||||:|.|.|:|:|:..|||.:|.:||.:||.:|.:|.:.|
Human   531 FSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAH 595

  Fly   580 PCKEPEE-VENIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMWWFFALMMLNSYTANLAAF 643
            ||....| |||.::::|:.|..:||||.||.:::|||.|||::.|:||||.|::::|||||||||
Human   596 PCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAF 660

  Fly   644 LTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTKTNDE 708
            ||..|..:.|:||:|||.|:||:|||:..|:||.||:.|..||::|||..| |:.||...|.|:|
Human   661 LTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFM-SSKPSALVKNNEE 724

  Fly   709 GVERVQKGKNLYAFLMESTTLEYNVERKCDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLG 773
            |::|.....  ||.||||||:||..:|.|:|.||||.:|.|.|||..|..||||.:|:.|:|:|.
Human   725 GIQRALTAD--YALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQ 787

  Fly   774 ELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVGGVFLVLGLGLLSAMVLGCTEFLWN 838
            |..:|..:|.|||:    |..|  .:|:..:...||::.:||:|:||..||:.::::...||::.
Human   788 EEDKLHIMKEKWWR----GSGC--PEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYK 846

  Fly   839 VKSVAIEEKISLKEAFKSEALFA 861
            ::..|..|:.|.......|..|:
Human   847 LRKTAEREQRSFCSTVADEIRFS 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	130/400 (33%)
		ANF_receptor	39..379	CDD:279440	120/370 (32%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	183/373 (49%)
		Lig_chan	548..812	CDD:278489	126/264 (48%)
GRIK3	NP_000822.2	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	131/402 (33%)
		ANF_receptor	55..398	CDD:279440	120/366 (33%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	183/373 (49%)
		Lig_chan	564..832	CDD:278489	131/276 (47%)
		Glutamate binding. /evidence=ECO:0000250	690..692		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155824
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.660