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Protein Alignment clumsy and GRIK2

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_068775.1	Gene:	GRIK2 / 2898	HGNCID:	4580	Length:	908	Species:	Homo sapiens

Alignment Length:	881	Identity:	341/881 - (38%)
Similarity:	508/881 - (57%)	Gaps:	69/881 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 YSLFLTHFLLIALPVLADIDRSQFMVGSIF----TSDKDESEIAFRTAVDRANILERNVELVP-- 60
            ||...||.|               ..|.||    :......|:|||.||   |.:.||..|:|
Human    28 YSQGTTHVL---------------RFGGIFEYVESGPMGAEELAFRFAV---NTINRNRTLLPNT 74

  Fly    61 IVVY----ANTDDSFIMEKMVCNLISQGVIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNES 121
            .:.|    .|..|||...|..|:.:|.||.||||||..||::.:.|||:.|.:|||...|  ...
Human    75 TLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRW--KHQ 137

  Fly   122 IPDREHSTMTLNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEPISNPTTV 186
            :.|.:.| ..::::||...||:.:.::||.|.|::.||||:....|.:||::::.....:....:
Human   138 VSDNKDS-FYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKI 201

  Fly   187 KQLGPGD--DHRPFLKEIKLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSID 249
            :|| |.|  |.:|.|||:|...:..:|..|:.:....||:||..:.|:.||.......||..::|
Human   202 RQL-PADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALD 265

  Fly   250 FG--ELSGVEANITTVRLMDPSDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMI--------- 303
            ..  ..|||  |:|..|:::..:..|.:::..| ..|:.:.      |.:..|.::
Human   266 VEPYRYSGV--NMTGFRILNTENTQVSSIIEKW-SMERLQA------PPKPDSGLLDGFMTTDAA 321

  Fly   304 LLNDAVWLFSKGLTELGIFEELTAPDLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNE-NGQ 367
            |:.|||.:.|..:.:   |.::|...|:|.|.|||.||.|.:..||....|..||||.||: ||.
Human   322 LMYDAVHVVSVAVQQ---FPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGL 383

  Fly   368 RSFFTLRFMELNSDGFLDLATWDPVNGLDVLNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLRE 432
            |:.|.|..:.|..:|...:.||||.:||::....:.....:...|||::.||::.|..|::..::
Human   384 RTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKK 448

  Fly   433 PQEGEILTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNAD 497
            ..:.  |.||.|:|||.|||:.|::.:|.|.:|.|:..||||||.:.....|:|:||:|||..||
Human   449 SDKP--LYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKAD 511

  Fly   498 LGICDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISL 562
            |.:..|.:|..|.:.:||:.||||||||||:.||......:||||:|.|.|:|:|:..|||.:|.
Human   512 LAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSC 576

  Fly   563 LLFALARMAPDDWENPHPCK-EPEEVENIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMWW 626
            :||.:||.:|.:|.|||||. :.:.|||.::::|:.|..:|:||.||.:::|||.|||:|.|:||
Human   577 VLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWW 641

  Fly   627 FFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQKMW 691
            ||.|::::|||||||||||..|..:.|:||:|||.|:||:|||:..|:||.||:.|..|||.|||
Human   642 FFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMW 706

  Fly   692 TAMESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVERKCDLVQIGGWLDYKSYGIAMP 756
            ..|.|...||..|:|:||::||....  |||||||||:|:..:|.|:|.||||.:|.|.||:..|
Human   707 AFMSSRRQSVLVKSNEEGIQRVLTSD--YAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTP 769

  Fly   757 FNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVGGVFLVLG 821
            ..||||.:|:.|:|:|.|.|:|..:|.|||:    |..|  .:|:..:...||::|:||:|:||.
Human   770 MGSPYRDKITIAILQLQEEGKLHMMKEKWWR----GNGC--PEEESKEASALGVQNIGGIFIVLA 828

  Fly   822 LGLLSAMVLGCTEFLWNVKSVAIEEKISLKEAFKSE 857
            .||:.::.:...|||:..|..|..||.|...|...|
Human   829 AGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEE 864

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.