DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and GRID1

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_060021.1	Gene:	GRID1 / 2894	HGNCID:	4575	Length:	1009	Species:	Homo sapiens

Alignment Length:	1041	Identity:	265/1041 - (25%)
Similarity:	447/1041 - (42%)	Gaps:	181/1041 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SLFLTHFLLIALPVLADIDRSQFMVGSIFTSDKDESEIAFRTAVDRANILERNVELVPI-----V 62
            :|:|..::...:.|.||   |...:|:||..:..:.:..|:.||...::.:..::...|     |
Human     5 TLWLLPWICQCVSVRAD---SIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKV 66

  Fly    63 VYANTDDSFIMEKMVCNLISQGVIAIFGPSTG-SSSDIIASICDTLDIPHIVYDWIPNESIPDRE 126
            :.||.....:.|  .|:|::||::|:. .||| :|::.:.|:.|.:.|||:.....|..|    .
Human    67 IEANNPFQAVQE--ACDLMTQGILALV-TSTGCASANALQSLTDAMHIPHLFVQRNPGGS----P 124

  Fly   127 HSTMTLNVHPDN----------LLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEPIS 181
            .:...||..||.          :.|:..:..:|....|:.|.:.|:::.:::.||..|.....:.
Human   125 RTACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLG 189

  Fly   182 NPTTVKQLGPGDDH-----RPFLKEIKLS----TDNCLILHCAPDNLLKILQQANELKMLGEYQS 237
            ...:::::.....|     ...:|..:|:    |....||..:|......:.:|.|..:..:
Human   190 LDVSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLASK--- 251

  Fly   238 VFIPLLDTHSIDFG-ELSGVE---------ANITTVRLMDPSDFHVKNVVHDWEEREKREGRYFK 292
                  |:|.:... |:|..|         ..:|.||.:.||       ..|.::..:...|...
Human   252 ------DSHWVFVNEEISDPEILDLVHSALGRMTVVRQIFPS-------AKDNQKCTRNNHRISS 303

  Fly   293 V--DPNRVKSQMILLNDAVWLFSKGLTELGIFEEL-------TAPDLECRRK--KPWPFGKRIIE 346
            :  ||.....||:.::: ::|:...|.....|...       :...|.|.||  |||..|:.:::
Human   304 LLCDPQEGYLQMLQISN-LYLYDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLD 367

  Fly   347 FIKARSEETSTGRIDFNENGQRSFFTLR-----FMELNSDGFLDLATWDPVNGLDVLNDDEESEK 406
            .||.......||.::|.|:....:....     :.|........|||||...||    :....|:
Human   368 TIKKGHITGLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKGL----NGSLQER 428

  Fly   407 RVGQKLSNKTFIVSSRLGAPFLTLREPQEGEILTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPD 471
            .:|.:|...|..|.:.|..||:.:.|    .||....||:|:|||:::.:||.|.||:|...:||
Human   429 PMGSRLQGLTLKVVTVLEEPFVMVAE----NILGQPKRYKGFSIDVLDALAKALGFKYEIYQAPD 489

  Fly   472 GKYGALNKVTQT-WDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPP 535
            |:||  :::..| |:|::.:||...|||.|..:|:|..|...|||:..:|...:.||..| |...
Human   490 GRYG--HQLHNTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGILIKK-PEEK 551

  Fly   536 TDLFSFLSPFSLDVWIYMGSAYLFISLLLFALAR---MAPDDWENPHPCKEPEEVENIWSIMNTT 597
            ..:||..:||...||..:.:|...:.:|:|.|.|   :.......|.|....       ::.:..
Human   552 ISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRAQSAAQPRPSASA-------TLHSAI 609

  Fly   598 WLSIGSLMGQGCDILPKAASTRLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQ 662
            |:..|:.:.||.:....:.:.|:|.|.||.|.|::.:|||||||||||.||..|.|.:.:||:.|
Human   610 WIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQ 674

  Fly   663 SKIKYGAMAGGSTMGFFRDSNF------STYQKMWTAMES--------ASPSVFTKTNDEGVERV 713
            .::.||.:...:...:||....      ||:.::|..:..        :|||       ||:.:.
Human   675 VEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSSPS-------EGIRKA 732

  Fly   714 QKGKNLYAFLMESTTLEYN--VERKCDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLGELG 776
            :||.  ||||.:...:||.  .:..|.:..||..:..|.||||:...||||...|..:|:|.:.|
Human   733 KKGN--YAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTG 795

  Fly   777 QLAELKRKWWKEMHGGGNCEKSDEDG--GDTPELGLENVGGVFLVLGLGLLSAMVLGCTEFLWNV 839
            .|..||:|||..|   |.|:.:....  .|...|.|.:..|||.:|.:|||.|.::...|..||.
Human   796 DLDVLKQKWWPHM---GRCDLTSHASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALELWWNS 857

  Fly   840 KSVAIEEKISLKEAFKSEALFAARIWITTKPVHTSSESGSSNSSSSSSSRSKHSFKSQGLSMKSL 904
            .....|.....||             :..:.||                |..:|...:.::.|.:
Human   858 NRCHQETPKEDKE-------------VNLEQVH----------------RRMNSLMDEDIAHKQI 893

  Fly   905 KSSGYQDVEASVHSKLKKIGSMFSLKSQKTVTPPPEIGWKLDKSTQIDVVPTSDVDQELIPEVEP 969
            .       .||:.....::|   .|...:|:.|..|.     ::||:.|       ...:||...
Human   894 S-------PASIELSALEMG---GLAPTQTLEPTREY-----QNTQLSV-------STFLPEQSS 936

  Fly   970 H 970
            |
Human   937 H 937

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	88/420 (21%)
		ANF_receptor	39..379	CDD:279440	79/390 (20%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	128/392 (33%)
		Lig_chan	548..812	CDD:278489	86/284 (30%)
GRID1	NP_060021.1	Interaction with CBLN1. /evidence=ECO:0000250\|UniProtKB:Q61627	21..436		94/445 (21%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	89/425 (21%)
		ANF_receptor	41..400	CDD:279440	78/382 (20%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	128/392 (33%)
		Lig_chan	564..841	CDD:278489	90/295 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	930..954		3/8 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155788
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740