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Protein Alignment clumsy and GRIA3

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_000819.4	Gene:	GRIA3 / 2892	HGNCID:	4573	Length:	894	Species:	Homo sapiens

Alignment Length:	859	Identity:	288/859 - (33%)
Similarity:	450/859 - (52%)	Gaps:	70/859 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VGSIFTSDKDESEIAFRTAVD----RANILERNVELVPIVVYANTDDSFIMEKMVCNLISQGVIA 87
            :|.:|..:..:...|||.||.    ..|..|:...|...|.:.::.:||.:....|:..|:||.|
Human    36 IGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYA 100

  Fly    88 IFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESIPDREHSTMTLNVHPDNLLLSQGLAEIVQSF 152
            |||.....|.:.:.|.|..|....:      ..|.|........:.:.|   .|...:..::..:
Human   101 IFGFYDQMSMNTLTSFCGALHTSFV------TPSFPTDADVQFVIQMRP---ALKGAILSLLGHY 156

  Fly   153 AWRSFTVVYETDKELQQLQDILQVGEPISNPTTVKQLGPGDDHRPF---LKEIKLSTDNCLILHC 214
            .|..|..:|:|::....||.|::.....:...|.:.:|...|.:.|   ::|:....:...::.|
Human   157 KWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDC 221

  Fly   215 APDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFGEL-------SGVEANITTVRLMDPSDFH 272
            ..:.:..||:|   :.:||::...:..:|  .::.|.::       .|  ||||..::::..:..
Human   222 EVERINTILEQ---VVILGKHSRGYHYML--ANLGFTDILLERVMHGG--ANITGFQIVNNENPM 279

  Fly   273 VKNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDAVWLFSKGLTEL-----GIFEELTAPDLEC 332
            |:..:..|...::||....|..|  :|....|.:||:.:.::....|     .:....:|.|...
Human   280 VQQFIQRWVRLDEREFPEAKNAP--LKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLA 342

  Fly   333 RRKKPWPFGKRIIEFIKARSEETSTGRIDFNENGQRSFFTLRFMELNSDGFLDLATWD------P 391
            ....||..|..|...:|....:..||.|.|:..|:|:.:|:...|:...|......|:      |
Human   343 NPAVPWSQGIDIERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVP 407

  Fly   392 VNGLDVLNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLREPQEGEILTGNSRYEGYSIDLINEI 456
            .:...:.||...||        |:|.:|::.|.:|::..::..|.  |.||.|||||.:||..||
Human   408 FSDQQISNDSASSE--------NRTIVVTTILESPYVMYKKNHEQ--LEGNERYEGYCVDLAYEI 462

  Fly   457 AKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMT 521
            ||.:..|::..:..||||||.:..|:.|:|:|.:|:.|.||:.:..||:|..|.:.:||:.|||:
Human   463 AKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMS 527

  Fly   522 LGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDW------ENPHP 580
            |||||:..||......:||||.|.:.::|:.:..||:.:|::||.::|.:|.:|      |.|..
Human   528 LGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRD 592

  Fly   581 CKEPEEVENIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMWWFFALMMLNSYTANLAAFLT 645
            .:.|.:..|.:.|.|:.|.|:|:.|.|||||.|::.|.|:|.|:||||.|::::|||||||||||
Human   593 PQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLT 657

  Fly   646 NSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTKTNDEGV 710
            ..|..:.|.||||||.|::|.||.:..|||..|||.|..:.|:|||:.|:||.|||||||..:||
Human   658 VERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGV 722

  Fly   711 ERVQKGKNLYAFLMESTTLEYNVERK-CDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLGE 774
            .||:|.|..:|||:|||..||..:|| ||.:::||.||.|.||:|.|..|..|..::.|||||.|
Human   723 ARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNAVNLAVLKLNE 787

  Fly   775 LGQLAELKRKWWKEMHGGGNCEKSDEDGGD-TPELGLENVGGVFLVL--GLGLLSAMVLGCTEFL 836
            .|.|.:||.|||   :..|.|.....|..| |..|.|.||.|||.:|  ||||  ||::...||.
Human   788 QGLLDKLKNKWW---YDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGL--AMMVALIEFC 847

  Fly   837 WNVKSVAIEEKISL 850
            :  ||.|..:::.|
Human   848 Y--KSRAESKRMKL 859

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.