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Protein Alignment clumsy and GRIA2

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_000817.5	Gene:	GRIA2 / 2891	HGNCID:	4572	Length:	883	Species:	Homo sapiens

Alignment Length:	934	Identity:	308/934 - (32%)
Similarity:	478/934 - (51%)	Gaps:	90/934 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LTHFLLIALPVL----ADIDRSQFMVGSIFTSDKDESEIAFRTAVDRANILERNVELVPIVVYAN 66
            :.|..::..|||    ..:..:...:|.:|....|:...|||..:.:.:..|  ..|.|.:....
Human     4 IMHISVLLSPVLWGLIFGVSSNSIQIGGLFPRGADQEYSAFRVGMVQFSTSE--FRLTPHIDNLE 66

  Fly    67 TDDSFIMEKMVCNLISQGVIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESIPDREHSTMT 131
            ..:||.:....|:..|:||.||||.....|.:.|.|.|.||.:..|      ..|.|........
Human    67 VANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFI------TPSFPTDGTHPFV 125

  Fly   132 LNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEPISNPTTVKQLG------ 190
            :.:.||   |...|..:::.:.|..|..:|::|:.|..||.:|..........|...:|
Human   126 IQMRPD---LKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDK 187

  Fly   191 PGDDHRPFLKEIKLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFGELSG 255
            ..:.:|...::::|..:..:||.|..|.:..|:.|   :..:|::...:..::.......|:|..
Human   188 KDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQ---VITIGKHVKGYHYIIANLGFTDGDLLK 249

  Fly   256 VE---ANITTVRLMDPSDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDAVWLFSKGLT 317
            ::   ||::..:::|..|..|...:..|...|::|  |.......:|....|..|||.:.::.
Human   250 IQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKE--YPGAHTTTIKYTSALTYDAVQVMTEA-- 310

  Fly   318 ELGIFEELTAPDLECRRK-----------KPWPFGKRIIEFIKARSEETSTGRIDFNENGQRSFF 371
                |..|....:|..|:           .||..|..|...:|....|..:|.|.|::||:|..:
Human   311 ----FRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINY 371

  Fly   372 TLRFMELNSDGFLDLATWDPVNGLDV-LNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLREPQE 435
            |:..|||.::|...:..|..|:.:.| |.:........|  |.|||.:|::.|.:|::.::  :.
Human   372 TINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSG--LENKTVVVTTILESPYVMMK--KN 432

  Fly   436 GEILTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGI 500
            .|:|.||.|||||.:||..||||...||::..:..||||||.:..|:.|:|:|.:|:.|.||:.|
Human   433 HEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAI 497

  Fly   501 CDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLF 565
            ..||:|..|.:.:||:.|||:|||||:..||......:||||.|.:.::|:.:..||:.:|::||
Human   498 APLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLF 562

  Fly   566 ALARMAPDDW--ENPHPCKEPEEVE--NIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMWW 626
            .::|.:|.:|  |.....:|.:..|  |.:.|.|:.|.|:|:.|.|||||.|::.|.|:|.|:||
Human   563 LVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWW 627

  Fly   627 FFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQKMW 691
            ||.|::::|||||||||||..|..:.|.|||||:.|::|.||.:..|||..|||.|..:.:.|||
Human   628 FFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMW 692

  Fly   692 TAMESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVERK-CDLVQIGGWLDYKSYGIAM 755
            |.|.||.||||.:|..|||.||:|.|..||:|:|||..||..:|| ||.:::||.||.|.||||.
Human   693 TYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIAT 757

  Fly   756 PFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGD-TPELGLENVGGVFLV 819
            |..|..|..::.|||||.|.|.|.:||.|||   :..|.|...|....: |..|.|.||.|||.:
Human   758 PKGSSLRTPVNLAVLKLSEQGVLDKLKNKWW---YDKGECGAKDSGSKEKTSALSLSNVAGVFYI 819

  Fly   820 L--GLGLLSAMVLGCTEFLWNVKSVAIEEKISLKEAFKSEALFAARIWITTKPVHTSSESGSSNS 882
            |  ||||  ||::...||                 .:||.|        ..|.:..:..:.:.|.
Human   820 LVGGLGL--AMLVALIEF-----------------CYKSRA--------EAKRMKVAKNAQNINP 857

  Fly   883 SSSSSSRSKHSFKSQGLSMKSLKS 906
            |||.:|::..::| :|.::..::|
Human   858 SSSQNSQNFATYK-EGYNVYGIES 880

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.