DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment clumsy and Ir41a

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_995744.4	Gene:	Ir41a / 2768714	FlyBaseID:	FBgn0040849	Length:	648	Species:	Drosophila melanogaster

Alignment Length:	570	Identity:	109/570 - (19%)
Similarity:	178/570 - (31%)	Gaps:	175/570 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   390 DPVNGLDVLND-------DEESEKRVGQKLSNKT-------FIVSS---RLGAPFLT--LREPQE 435
            |..|.|.|:.|       |.::.|.||:|..|.:       ::.|.   :.|.....  |...|.
  Fly   146 DQPNILFVVRDHSSASSFDIKTNKFVGRKAENPSQMILVDRYLASEQRFQFGKSLFADKLNNLQG 210

  Fly   436 GEILTGNSRYEGYSI------------------DLIN------EIAKMLNFKFEFRMSPDGKYGA 476
            .|::.....|..|::                  |..|      |...:|||..:|..:......|
  Fly   211 REVIIAGFDYPPYTVIKHNMSTNAQDMGVSGESDFKNVYIDGTETRIVLNFCEQFNCTIQIDSSA 275

  Fly   477 LN---KV--TQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTP-- 534
            .|   ||  ..:.||.:..||:..||:.|..:.........:|.:...:..||:.|.   |.|
  Fly   276 ANDWGKVYPNMSGDGALGMLINRKADICIGAMYSWYEDYTYLDLSMYLVRSGITCLV---PAPLR 337

  Fly   535 PTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENPHPCKE---------------- 583
            .|..:..|.||...:|          :.:|..|             |.|
  Fly   338 LTSWYLPLEPFKETLW----------AAILLCL-------------CAEATGLVLAYKSEQALYV 379

  Fly   584 -PEEVENIWSIMN----TTWLSIGSLMGQGCDILPKAAS--TRLVTGMWWFFALMMLNSYTANLA 641
             |...|..|:..:    ||:....|..|..     ||.|  .|::....:...|::.:.|...||
  Fly   380 LPGYREGWWTCTSFGVCTTFKLFISQSGNS-----KAYSLTVRVLLFACFLNDLIITSIYGGGLA 439

  Fly   642 AFLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTK-- 704
            :.||    ..|::.|.|...:.:              |....::...:.|.:...||.....|
  Fly   440 SILT----IPSMDEAADTVTRLR--------------FHRLQWAANSEAWVSAIRASDEALVKDI 486

  Fly   705 -------TNDE--------------GVERVQKGKNLYAFLMESTTLEYNVERKCDLVQIGGWLDY 748
                   ::||              .|||:..|.......:....::..|..|.|:        |
  Fly   487 LYNFHIYSDDELLRLAQDQHMRIGFTVERLPFGHFAIGNYLGPQAIDQLVIMKDDI--------Y 543

  Fly   749 KSYGIA-MPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCE-----------KSDED 801
            ..|.:| :|...|...:::..:......|     ..|:|:......|..           ...:|
  Fly   544 FQYTVAFVPRLWPLLDKLNTLIYSWHSSG-----FDKYWEYRVVADNLNLKIQQQVQETMTGTKD 603

  Fly   802 GGDTPELGLENVGGVFLVLGLGLLSAMVLGCTEFLWNVKSVAIEEKISLK 851
            .|..| ||:.|..|..:|..||    ..:....||..:....|.::.:||
  Fly   604 IGPVP-LGMSNFAGFIIVWILG----SAIATLTFLLELSLTYILKQSNLK 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	2/5 (40%)
		ANF_receptor	39..379	CDD:279440
		PBP2_iGluR_Kainate	414..787	CDD:270432	82/462 (18%)
		Lig_chan	548..812	CDD:278489	53/321 (17%)
Ir41a	NP_995744.4	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462650
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840