DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and Grin2d

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	XP_038951440.1	Gene:	Grin2d / 24412	RGDID:	2740	Length:	1334	Species:	Rattus norvegicus

Alignment Length:	953	Identity:	207/953 - (21%)
Similarity:	358/953 - (37%)	Gaps:	271/953 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VGSIFTSDKDESEIAFRTAVDRANILERNVELVPIVVYANTDDSFIMEKMVCNLIS----QGVIA 87
            |..:|:.....:|.|.......|.:....:::.|:.:..|..|...:...:|:|:|    .||:.
  Rat    50 VALVFSGPAYAAEAARLGPAVAAAVRSPGLDVRPVALVLNGSDPRSLVLQLCDLLSGLRVHGVVF 114

  Fly    88 IFGPSTGSSSDIIASICDTL----DIPHI-VYDWIPNESIPDREHST-MTLNVHPDNLLLSQGLA 146
                ...|.:..:|.|.|.|    .:|.: |:........|..:.|| :.|....:..|  |.:.
  Rat   115 ----EDDSRAPAVAPILDFLSAQTSLPIVAVHGGAALVLTPKEKGSTFLQLGSSTEQQL--QVIF 173

  Fly   147 EIVQSFAWRSFTVVYETDKELQQLQDILQVGEPISNPTTVKQLGPGDDHRPFLKEIKLSTDNCLI 211
            |:::.:.|.||..|                       ||   ..||  ||.||..|::.||..|:
  Rat   174 EVLEEYDWTSFVAV-----------------------TT---RAPG--HRAFLSYIEVLTDGSLV 210

  Fly   212 --------------------------------LHCAPDNLLKILQQANELKMLGEYQSVFI---- 240
                                            |.||.:....:.:.|.|..:.|.....|:
  Rat   211 GWEHRGALTLDPGAGEAVLGAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGPGYVWFMVGPQ 275

  Fly   241 ------------PLLDTHSIDFGELSG-----------------------VEANITTVR------ 264
                        |||         |.|                       |.|.:..|.
  Rat   276 LAGGGGSGVPGEPLL---------LPGGSPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQAL 331

  Fly   265 LMD----PS---DFHVKNVVH------------DWEERE---KREGRYFKVDPNRVKSQMILLND 307
            |.|    |.   |...:|..|            .|:.|:   ..:|  |.|:|:.|  .:.|..|
  Rat   332 LRDYGFLPELGHDCRTQNRTHRGESLHRYFMNITWDNRDYSFNEDG--FLVNPSLV--VISLTRD 392

  Fly   308 AVWLFSKGLTELGIFEELTAPDLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNENGQRSFFT 372
            ..|      ..:|.:|:.|.       :..:|...|...|::.         :|..::
  Rat   393 RTW------EVVGSWEQQTL-------RLKYPLWSRYGRFLQP---------VDDTQH------- 428

  Fly   373 LRFMELNSDGFLDLATWDPVNGLDVLNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLREPQEGE 437
            |....|....|:.:...||::| ..:.|......::     |:|.  |....||     .|::
  Rat   429 LTVATLEERPFVIVEPADPISG-TCIRDSVPCRSQL-----NRTH--SPPPDAP-----RPEK-- 478

  Fly   438 ILTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICD 502
                 ...:|:.||::..:|..:.|.::..:..:||:|  .|:...|:|::.::....||:.|..
  Rat   479 -----RCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHG--KKIDGVWNGMIGEVFYQRADMAIGS 536

  Fly   503 LTMTSSRRQAVDFTPPFMTLGISILFSK-----------------PPTPPTDLFSFLSPFSLDVW 550
            ||:...|.:.|||:.||:..|||::.::                 ||..|       .|:|..||
  Rat   537 LTINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLAFAWLTPPMSP-------EPYSPAVW 594

  Fly   551 IYMGSAYL-FISLLLFALARMAPDDWENPHPC-KEPEEVENIWSIMNTTWLSIGSLMGQGCDI-L 612
            :.|....| .:::.:|....::|..:...... |.|.  .:.::|..:.||....:......: .
  Rat   595 VMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPG--GSTFTIGKSIWLLWALVFNNSVPVEN 657

  Fly   613 PKAASTRLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQ------SKIKYGAMA 671
            |:..:::::..:|.|||::.|.|||||||||:......::::...|...|      ..:|:|.:.
  Rat   658 PRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVP 722

  Fly   672 GGSTMGFFRDSNFSTYQKMWTAM-ESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVER 735
            .|||....|    |.|..|.:.| ....|.|     :|.:.:::.|| |.||:.::..|.| :.|
  Rat   723 NGSTEKNIR----SNYPDMHSYMVRYNQPRV-----EEALTQLKAGK-LDAFIYDAAVLNY-MAR 776

  Fly   736 K---CDLVQIGGWLDYKS--YGIAMPFNSPYRKQISAAVLK-LGELGQLAELKRKWWKEMHGGGN 794
            |   |.||.||....:.:  ||||:...|.:::.|..|:|: ||: .::..|:|.|.     .|.
  Rat   777 KDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGD-DEIEMLERLWL-----SGI 835

  Fly   795 CEKSDEDGGDTPELGLENVGGVFLVLGLGLLSAMVLGCTEFLW 837
            |. :|:....:.:|.::|:.|||.:    ||.||.|....|.|
  Rat   836 CH-NDKIEVMSSKLDIDNMAGVFYM----LLVAMGLSLLVFAW 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	87/477 (18%)
		ANF_receptor	39..379	CDD:279440	80/448 (18%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	104/405 (26%)
		Lig_chan	548..812	CDD:278489	72/279 (26%)
Grin2d	XP_038951440.1	PBP1_iGluR_NMDA_NR2	46..410	CDD:380601	77/419 (18%)
		PBP2_iGluR_NMDA_Nr2	427..838	CDD:270436	113/466 (24%)
		PHA03307	<1125..>1312	CDD:223039
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349726
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740