DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and Grin2c

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_036707.3	Gene:	Grin2c / 24411	RGDID:	2739	Length:	1250	Species:	Rattus norvegicus

Alignment Length:	907	Identity:	200/907 - (22%)
Similarity:	353/907 - (38%)	Gaps:	230/907 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 RTAVDRANILERNVELVPIVV-YANTDDSFIMEKMVCNLI------------------------- 81
            ||.:...|.|:..:|:.|:.| ..||:.|.|:.: :|.|:
  Rat    60 RTRLTSQNFLDLPLEIQPLTVGVNNTNPSSILTQ-ICGLLGAARVHGIVFEDNVDTEAVAQLLDF 123

  Fly    82 --SQGVIAIFGPSTGSS------------SDIIASICDTLDIPHIV---YDWIPNESIPDREHST 129
              ||..:.|...|.||:            ..:..|:...|.:...|   |||         ....
  Rat   124 VSSQTHVPILSISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDW---------SAFA 179

  Fly   130 MTLNVHPDNLLLSQGLAEIVQS--FAWRSFTVVYETDKELQQLQDILQVGEPISNPTTVKQLGPG 192
            :..::||.:.|..:|:..:..:  .:||              |.|:|.:           :||||
  Rat   180 VITSLHPGHALFLEGVRAVADASYLSWR--------------LLDVLTL-----------ELGPG 219

  Fly   193 DDHRPFLKEIKLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFGELSGVE 257
            .......:.::......|:.:|:.:....:..:|.:..::|......:|.|...|.|
  Rat   220 GPRARTQRLLRQVDAPVLVAYCSREEAEVLFAEAAQAGLVGPGHVWLVPNLALGSTD-------- 276

  Fly   258 ANITTVRLMDPSDFHV---KNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDAVWLFSKGL--- 316
                    ..|:.|.|   ..|...|....:::.|                 |.|.:.:.|.
  Rat   277 --------APPAAFPVGLISVVTESWRLSLRQKVR-----------------DGVAILALGAHSY 316

  Fly   317 -TELGIFEELTAPDLECRRKKPWPFGKRIIEFIKARSEETSTGR-IDFNENGQRSFFTLRFMELN 379
             .:.|   .|.||..:| |..|.|.......|.:.....|..|| ..|:..|.....|:..:.||
  Rat   317 RRQYG---TLPAPAGDC-RSHPGPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVRPTMVVIALN 377

  Fly   380 SDGFLDL-ATWD--------PV-----NGLDVLNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTL 430
            .....:: ..||        ||     ..|..:.|             ::...|::....||:.:
  Rat   378 RHRLWEMVGRWDHGVLYMKYPVWPRYSTSLQPVVD-------------SRHLTVATLEERPFVIV 429

  Fly   431 REPQEGEILTG-------------NSRY-------------EGYSIDLINEIAKMLNFKFEFRMS 469
            ..|..|   ||             |..:             :|:.||::.::||::.|.::..:.
  Rat   430 ESPDPG---TGGCVPNTVPCRRQSNHTFSSGDLTPYTKLCCKGFCIDILKKLAKVVKFSYDLYLV 491

  Fly   470 PDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSKP--P 532
            .:||:|  .:|...|:|::.::....||:.|..||:...|.:.:||:.||:..|||::.|:.  .
  Rat   492 TNGKHG--KRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIIDFSVPFVETGISVMVSRSNGT 554

  Fly   533 TPPTDLFSFLSPFSLDVWIYMGSAYL-FISLLLFALARMAPDDW-ENPHPCKEPEEVENIWSIMN 595
            ..|:   :||.|:|..||:.|....| .:::.:|.....:|..: :|....|:|....  ::|..
  Rat   555 VSPS---AFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTKGKKPGGPS--FTIGK 614

  Fly   596 TTWLSIGSLMGQGCDI-LPKAASTRLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDL 659
            :.||....:......| .|:..:::::..:|.|||::.|.|||||||||:...:..::::...|.
  Rat   615 SVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDK 679

  Fly   660 AAQ------SKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTKTNDEGVE----RVQ 714
            ..|      ...::|.:..|||....|    |.|:.|.|.|        .|.|...||    .::
  Rat   680 KFQRPQDQYPPFRFGTVPNGSTERNIR----SNYRDMHTHM--------VKFNQRSVEDALTSLK 732

  Fly   715 KGKNLYAFLMESTTLEY--NVERKCDLVQIGGWLDYKS--YGIAMPFNSPYRKQISAAVLKLGEL 775
            .|| |.||:.::..|.|  ..:..|.||.||....:.:  |||||..:|.:::.|..|:|:|...
  Rat   733 MGK-LDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQLLGD 796

  Fly   776 GQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVGGVFLVLGLGLLSAMVLGCTEFLW 837
            |:..:|:..|.     .|.|: ::::...:.:|.::|:.|||.:    ||.||.|....|.|
  Rat   797 GETQKLETVWL-----SGICQ-NEKNEVMSSKLDIDNMAGVFYM----LLVAMGLALLVFAW 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	76/419 (18%)
		ANF_receptor	39..379	CDD:279440	70/388 (18%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	108/417 (26%)
		Lig_chan	548..812	CDD:278489	72/280 (26%)
Grin2c	NP_036707.3	PBP1_iGluR_NMDA_NR2	41..397	CDD:380601	74/408 (18%)
		PBP2_iGluR_NMDA_Nr2	413..813	CDD:270436	110/428 (26%)
		NMDAR2_C	850..>925	CDD:402274
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349742
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.830