Protein Alignment clumsy and Grin2b

DIOPT Version :10

• Sequence 1: NP_001036373.1
• Gene: clumsy / 35394
• FlyBaseID: FBgn0026255
• Length: 1002
• Species: Drosophila melanogaster
• Sequence 2: NP_036706.1
• Gene: Grin2b / 24410
• RGDID: 2738
• Length: 1482
• Species: Rattus norvegicus
• Alignment Length: 1116
• Identity: 249/1116 - (22%)
• Similarity: 442/1116 - (39%)
• Gaps: 279/1116 - (25%)

  Fly    10 LLIALPVLADIDRSQ----------FMVGSIFTSDKDESEIAFRTAVDRANILERNVELVP---I 61
            :|..|.|.....|||          .:||   |||    |:|.:.|.::.:.  .::.:||   :
  Rat    15 VLAVLAVSGSKARSQKSPPSIGIAVILVG---TSD----EVAIKDAHEKDDF--HHLSVVPRVEL 70

  Fly    62 VVYANTDDSFIMEKMVCNLIS----QGVIAIFGPSTGSSSDIIASICDTLD----IPHIVYDWIP 118
            |....||...|:.: :|:|:|    |||  :|...|  ..:.||.|.|.:.    .|.:......
  Rat    71 VAMNETDPKSIITR-ICDLMSDRKIQGV--VFADDT--DQEAIAQILDFISAQTLTPILGIHGGS 130

  Fly   119 NESIPDREHSTMTLNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDIL-QVGEPISN 182
            :..:.|::.|:|.....|.....:..:..|::.:.|..|::|   .......||.: ::...|.|
  Rat   131 SMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIV---TTYFPGYQDFVNKIRSTIEN 192

  Fly   183 --------PTTVKQLGPGDDHRPFLKEIKLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVF 239
                    ...:..:...|.......::|......::|:|..:....|.:.||.:.:.|...:..
  Rat   193 SFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWI 257

  Fly   240 IPLLDTHSIDFGELSGVEANITTVRLMDPSDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMIL 304
            :|.|            |..:..||    ||:|....:...::|.:...       |.||:..:.:
  Rat   258 VPSL------------VAGDTDTV----PSEFPTGLISVSYDEWDYGL-------PARVRDGIAI 299

  Fly   305 LNDAVWLFSKGLTELGIFEELTAPDLECRRKKPWPFGKRIIE---FIKARSEETSTGR-IDFNEN 365
            :..|.   |..|:|.....|   |...|.....    |||.:   ..:.....|..|| :.|:|:
  Rat   300 ITTAA---SDMLSEHSFIPE---PKSSCYNTHE----KRIYQSNMLNRYLINVTFEGRNLSFSED 354

  Fly   366 GQRSFFTLRFMELNSDGFLDLATWDPVNGLDVLNDDE-------------ESEKRVGQKLSNKTF 417
            |.:....|..:.||.:     ..|:.|.   ...|..             |:|::....||
  Rat   355 GYQMHPKLVIILLNKE-----RKWERVG---KWKDKSLQMKYYVWPRMCPETEEQEDDHLS---- 407

  Fly   418 IVSSRLGAPFLTLRE-------------PQEGEILTGNSRYE----------GYSIDLINEIAKM 459
            ||:.. .|||:.:..             |.:..|::.|...|          |:.||::.:|:|.
  Rat   408 IVTLE-EAPFVIVESVDPLSGTCMRNTVPCQKRIISENKTDEEPGYIKKCCKGFCIDILKKISKS 471

  Fly   460 LNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGI 524
            :.|.::..:..:||:|  .|:..||:|::.:::...|.:.:..||:...|.:.|||:.||:..||
  Rat   472 VKFTYDLYLVTNGKHG--KKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGI 534

  Fly   525 SILFSKP--PTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENP---HPC--- 581
            |::.|:.  ...|:   :||.|||.|||:.|     |:.||:.:...:...::.:|   :.|
  Rat   535 SVMVSRSNGTVSPS---AFLEPFSADVWVMM-----FVMLLIVSAVAVFVFEYFSPVGYNRCLAD 591

  Fly   582 -KEPEEVENIWSIMNTTWLSIGSLMGQGCDIL-PKAASTRLVTGMWWFFALMMLNSYTANLAAFL 644
             :||....  ::|....||..|.:......:. ||..:::::..:|.|||::.|.|||||||||:
  Rat   592 GREPGGPS--FTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFM 654

  Fly   645 TNSRQANSINSAEDLAAQ------SKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFT 703
            ......:.::...|...|      ...::|.:..|||....|::    |.:|...|        .
  Rat   655 IQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNN----YAEMHAYM--------G 707

  Fly   704 KTNDEGVE----RVQKGKNLYAFLMESTTLEYNVERK--CDLVQIGGWLDYKS--YGIAMPFNSP 760
            |.|..||:    .::.|| |.||:.::..|.|...|.  |.||.||....:.|  ||||:..:|.
  Rat   708 KFNQRGVDDALLSLKTGK-LDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSG 771

  Fly   761 YRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVGGVFLVLGLGL- 824
            :::|:..|:|:|...|::.||:..|..     |.|. ::::...:.:|.::|:.|||.:||..:
  Rat   772 WKRQVDLAILQLFGDGEMEELEALWLT-----GICH-NEKNEVMSSQLDIDNMAGVFYMLGAAMA 830

  Fly   825 LSAMVLGCTE-FLWN--------------------------VKSVAIEEKISLKEAFKSEALFAA 862
            ||.:...|.. |.|.                          :..|||||:.|:
  Rat   831 LSLITFICEHLFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSV------------ 883

  Fly   863 RIWITTKPVHTSSESGSSNSSSSSSSRSKHSFKSQGLSMKSLKSSGYQDVEASVHSKLKKIGSMF 927
                      .:|.:.:.|::.|:..|...:.|    :|.:|  ||......|....:::..|::
  Rat   884 ----------MNSPTATMNNTHSNILRLLRTAK----NMANL--SGVNGSPQSALDFIRRESSVY 932

  Fly   928 SLKSQKTV----------TPPPEIGWKLDKSTQIDVVPTSDVDQELIPEVEPHL---------PH 973
            .:...:..          .||.|                .::..:.|.|||...         .:
  Rat   933 DISEHRRSFTHSDCKSYNNPPCE----------------ENLFSDYISEVERTFGNLQLKDSNVY 981

  Fly   974 RHHHHHHHRHH 984
            :.|:|||||.|
  Rat   982 QDHYHHHHRPH 992

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	27..397	CDD:380605	80/393 (20%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	113/419 (27%)
Grin2b	NP_036706.1	PBP1_iGluR_NMDA_NR2	33..388	CDD:380601	81/412 (20%)
		PBP2_iGluR_NMDA_Nr2	403..803	CDD:270436	117/435 (27%)
		Pore-forming. /evidence=ECO:0000269|PubMed:24876489, ECO:0000305|PubMed:24876489	604..623		3/18 (17%)
		NMDAR2_C	840..1482	CDD:463148	33/197 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1161..1194
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1269..1301
		Interaction with DAPK1. /evidence=ECO:0000250|UniProtKB:Q01097	1292..1304
		PDZ-binding	1480..1482