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Protein Alignment clumsy and Grin2a

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_036705.3	Gene:	Grin2a / 24409	RGDID:	2737	Length:	1464	Species:	Rattus norvegicus

Alignment Length:	1136	Identity:	243/1136 - (21%)
Similarity:	417/1136 - (36%)	Gaps:	350/1136 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 DKDESEIAFRTAVDRANILERNVELVPIVVYANTDDSFIMEKMVCNLISQGVI--AIFGPSTGSS 96
            |..|.|:......::|..|..:|.:|.:::......|.|..  ||:|:|...|  .:||..|  .
  Rat    45 DVTERELRNLWGPEQATGLPLDVNVVALLMNRTDPKSLITH--VCDLMSGARIHGLVFGDDT--D 105

  Fly    97 SDIIASICDTLDIPHIVYDWIPNES-IPDREHSTMTLNVH-----------PDNLLLSQG----- 144
            .:.:|.          :.|:|.::: ||       .|.:|           |.:.....|
  Rat   106 QEAVAQ----------MLDFISSQTFIP-------ILGIHGGASMIMADKDPTSTFFQFGASIQQ 153

  Fly   145 ----LAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEPISNPTTVKQLGPGDDHRPFLKEIKLS 205
                :.:|:|.:.|..|::|                       ||:   .||  :|.|:..||.:
  Rat   154 QATVMLKIMQDYDWHVFSLV-----------------------TTI---FPG--YRDFISFIKTT 190

  Fly   206 TDN--------------------------------CLILHCAPDNLLKILQQANELKMLGEYQSV 238
            .||                                .::|:|:.|..:.||.:|..|.:.|.....
  Rat   191 VDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFW 255

  Fly   239 FIPLLDTHSIDFGELSGVEANITTVRLMDPSDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMI 303
            .:|.|            |..|...:....||.. :.....||:         :.::. ||:..:.
  Rat   256 IVPSL------------VSGNTELIPKEFPSGL-ISVSYDDWD---------YSLEA-RVRDGLG 297

  Fly   304 LLNDAVWLFSKGLTELGIFEELTAPDLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNENGQR 368
            :|..|.   |..|.:.....|..|   .|       :|       :|...||
  Rat   298 ILTTAA---SSMLEKFSYIPEAKA---SC-------YG-------QAEKPET------------- 329

  Fly   369 SFFTLRFMELNSDGFLDLATWDPVNGLD-----------------VLNDDEESEKRVGQKLSNKT 416
            ...||....:|       .|||   |.|                 |||.|.|.|| || |..|:|
  Rat   330 PLHTLHQFMVN-------VTWD---GKDLSFTEEGYQVHPRLVVIVLNKDREWEK-VG-KWENQT 382

  Fly   417 FIVSSRL-----------------------GAPFLTLRE-------------PQEGEILTGNSRY 445
            ..:...:                       .|||:.:.:             |....:...||..
  Rat   383 LSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTN 447

  Fly   446 E---------GYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGIC 501
            |         |:.||::.::::.:.|.::..:..:||:|  .||...|:|::.:::...|.:.:.
  Rat   448 EGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHG--KKVNNVWNGMIGEVVYQRAVMAVG 510

  Fly   502 DLTMTSSRRQAVDFTPPFMTLGISILFSKP--PTPPTDLFSFLSPFSLDVWIYMGSAYLFIS-LL 563
            .||:...|.:.|||:.||:..|||::.|:.  ...|:   :||.|||..||:.|....|.:| :.
  Rat   511 SLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPS---AFLEPFSASVWVMMFVMLLIVSAIA 572

  Fly   564 LFALARMAPDDWEN-------PHPCKEPEEVENIWSIMNTTWLSIGSLMGQGCDIL-PKAASTRL 620
            :|.....:|..:..       ||   .|.     ::|....||..|.:......:. ||..::::
  Rat   573 VFVFEYFSPVGYNRNLAKGKAPH---GPS-----FTIGKAIWLLWGLVFNNSVPVQNPKGTTSKI 629

  Fly   621 VTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQ------SKIKYGAMAGGSTMGFF 679
            :..:|.|||::.|.|||||||||:......:.:....|...|      ...::|.:..|||....
  Rat   630 MVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNI 694

  Fly   680 RDSNFSTYQKMWTAMESASPSVFTKTNDEGVE----RVQKGKNLYAFLMESTTLEYNVERK--CD 738
            |::....:|.|            |:.|..|||    .::.|| |.||:.::..|.|...|.  |.
  Rat   695 RNNYPYMHQYM------------TRFNQRGVEDALVSLKTGK-LDAFIYDAAVLNYKAGRDEGCK 746

  Fly   739 LVQIGGWLDYKS--YGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDED 801
            ||.||....:.:  ||||:...||:::||..|:|:....|::.||:..|..     |.|. ::::
  Rat   747 LVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLT-----GICH-NEKN 805

  Fly   802 GGDTPELGLENVGGVFLVLGLGLLSAMVLGCTEFLWNVKSVAIEEKISLKEAF--------KSEA 858
            ...:.:|.::|:.|||.:|.    :||.|....|:|       |.....|..|        :...
  Rat   806 EVMSSQLDIDNMAGVFYMLA----AAMALSLITFIW-------EHLFYWKLRFCFTGVCSDRPGL 859

  Fly   859 LFAAR--IWITTKPVHTSSESGSSNSSSSSSSRSKHSFKSQGLSMKSLKSSGYQDVEASVHSKLK 921
            ||:..  |:.....||...:..|.:.:.:.         ||...:|.|:|:             |
  Rat   860 LFSISRGIYSCIHGVHIEEKKKSPDFNLTG---------SQSNMLKLLRSA-------------K 902

  Fly   922 KIGSMFSLKSQKTVTPPPEIGWKLDKSTQIDVVPT------SD---------VDQELIPEVEPHL 971
            .|.:|.::.|.:..:|.....:....|..:|:|..      ||         :..:.:.|::..:
  Rat   903 NISNMSNMNSSRMDSPKRATDFIQRGSLIVDMVSDKGNLIYSDNRSFQGKDSIFGDNMNELQTFV 967

  Fly   972 PHRHHHHHHHRHHHHHHQPDQEHDRNPSPPE 1002
            .:||..:..:......| |...::.||:..|
  Rat   968 ANRHKDNLSNYVFQGQH-PLTLNESNPNTVE 997

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.