DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and Grik4

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_036704.1	Gene:	Grik4 / 24406	RGDID:	2734	Length:	956	Species:	Rattus norvegicus

Alignment Length:	798	Identity:	284/798 - (35%)
Similarity:	432/798 - (54%)	Gaps:	31/798 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 DDSFIMEKMVCNLISQGVIAIFGPSTG-SSSDIIASICDTLDIPHIVYDWIPNESIPDREHSTMT 131
            |..:...:.:|.::.:||:|:.|||:. :||.||::||...::||  :...|.|.:..:.....|
  Rat    74 DSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPH--FKVAPEEFVRFQLQRFTT 136

  Fly   132 LNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEPISNPTTVKQLGPGDDHR 196
            ||:||.|..:|..:|.|:..|...:..::....:.|..|:.:|:......:..:|:.|....|..
  Rat   137 LNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQFLISKDTLSVRMLDDTRDPT 201

  Fly   197 PFLKEIKLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFGELSGVEANIT 261
            |.||||:......:|:|........||.:|.||.|:..|.:.....|:........|.....||.
  Rat   202 PLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNIL 266

  Fly   262 TVRLMDPS-----DFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDAVWLFSKGLTELGI 321
            ...:.:.|     :|. :::...|:|....      |..........||.|||:.....:.||..
  Rat   267 GFSIFNQSHAFFQEFS-QSLNQSWQENCDH------VPFTGPALSSALLFDAVYAVVTAVQELNR 324

  Fly   322 FEELTAPDLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNENGQRSFFTLRFMELNSDGFLDL 386
            .:|:....|.|...:.|..|..::.:::....|..||.|:||..||||.:.|:.::...:||..:
  Rat   325 SQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALKILQFTRNGFRQI 389

  Fly   387 ATWDPVNGLDVLNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLREPQEGEILTGNSRYEGYSID 451
            ..|....||.:  |.......:...|.|.|.:|::.|..|:|.|:...:.  :.||.||||:.:|
  Rat   390 GQWHVAEGLSM--DSRLYASNISDSLFNTTLVVTTILENPYLMLKGNHQD--MEGNDRYEGFCVD 450

  Fly   452 LINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFT 516
            ::.|:|::|.|.::.|:..||.|| :.:...||.|:|.:||...|||.:..||:|:.|.:.:||:
  Rat   451 MLKELAEILRFNYKIRLVGDGVYG-VPEANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFS 514

  Fly   517 PPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENPHPC 581
            .||||||||||:..........||||.|||..||::|..|||.:|.:||.:||:.|.:|.:||||
  Rat   515 KPFMTLGISILYRVHMGRRPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPC 579

  Fly   582 KEP--EEVENIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMWWFFALMMLNSYTANLAAFL 644
            .:.  ..:.|.:|:.|:.|..:|..|.||..|.|:|.|||.|:|:||.|.|::::||||||||||
  Rat   580 AQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFL 644

  Fly   645 TNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTKTNDEG 709
            |..|....|.|.:|||.|:.|:||.:.|||:|.||::|.:.|||:||..|.|..||||.|:.:||
  Rat   645 TVQRMEVPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEG 709

  Fly   710 VERVQKGKNLYAFLMESTTLEYNVERKCDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLGE 774
            :.||....  ||||:|||..||..:|.|:|.||||.||.|.|||.||..|.:|.:...|:|:|.|
  Rat   710 IARVLNSN--YAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQE 772

  Fly   775 LGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVGGVFLVLGLGLLSAMVLGCTEFLWNV 839
            ..:|..||||||:    ||.|.|  |:......||:||:||:|:||..||:.|:.:...||||.:
  Rat   773 NNRLEILKRKWWE----GGKCPK--EEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTL 831

  Fly   840 KSVAIEEKISLKEAFKSE 857
            :.....| :|:.:...:|
  Rat   832 RHSEASE-VSVCQEMMTE 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	84/333 (25%)
		ANF_receptor	39..379	CDD:279440	80/316 (25%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	172/374 (46%)
		Lig_chan	548..812	CDD:278489	125/265 (47%)
Grik4	NP_036704.1	Periplasmic_Binding_Protein_type1	24..402	CDD:415822	85/338 (25%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	172/374 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349662
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.760