Protein Alignment clumsy and Grik4

DIOPT Version :10

• Sequence 1: NP_001036373.1
• Gene: clumsy / 35394
• FlyBaseID: FBgn0026255
• Length: 1002
• Species: Drosophila melanogaster
• Sequence 2: NP_036704.1
• Gene: Grik4 / 24406
• RGDID: 2734
• Length: 956
• Species: Rattus norvegicus
• Alignment Length: 799
• Identity: 284/799 - (35%)
• Similarity: 431/799 - (53%)
• Gaps: 33/799 - (4%)

  Fly    68 DDSFIMEKMVCNLISQGVIAIFGPSTG-SSSDIIASICDTLDIPHIVYDWIPNESIPDREHSTMT 131
            |..:...:.:|.::.:||:|:.|||:. :||.||::||...::||  :...|.|.:..:.....|
  Rat    74 DSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPH--FKVAPEEFVRFQLQRFTT 136

  Fly   132 LNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEPISNPTTVKQLGPGDDHR 196
            ||:||.|..:|..:|.|:..|...:..::....:.|..|:.:|:......:..:|:.|....|..
  Rat   137 LNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQFLISKDTLSVRMLDDTRDPT 201

  Fly   197 PFLKEIKLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFGELSGVEANIT 261
            |.||||:......:|:|........||.:|.||.|:..|.:.....|:........|.....||.
  Rat   202 PLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNIL 266

  Fly   262 TVRLMDPSDFHV------KNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDAVWLFSKGLTELG 320
            ...:.:.|  |.      :::...|:|....      |..........||.|||:.....:.||.
  Rat   267 GFSIFNQS--HAFFQEFSQSLNQSWQENCDH------VPFTGPALSSALLFDAVYAVVTAVQELN 323

  Fly   321 IFEELTAPDLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNENGQRSFFTLRFMELNSDGFLD 385
            ..:|:....|.|...:.|..|..::.:::....|..||.|:||..||||.:.|:.::...:||..
  Rat   324 RSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALKILQFTRNGFRQ 388

  Fly   386 LATWDPVNGLDVLNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLREPQEGEILTGNSRYEGYSI 450
            :..|....||.:  |.......:...|.|.|.:|::.|..|:|.|:...:.  :.||.||||:.:
  Rat   389 IGQWHVAEGLSM--DSRLYASNISDSLFNTTLVVTTILENPYLMLKGNHQD--MEGNDRYEGFCV 449

  Fly   451 DLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDF 515
            |::.|:|::|.|.::.|:..||.|| :.:...||.|:|.:||...|||.:..||:|:.|.:.:||
  Rat   450 DMLKELAEILRFNYKIRLVGDGVYG-VPEANGTWTGMVGELIARKADLAVAGLTITAEREKVIDF 513

  Fly   516 TPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENPHP 580
            :.||||||||||:..........||||.|||..||::|..|||.:|.:||.:||:.|.:|.:|||
  Rat   514 SKPFMTLGISILYRVHMGRRPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHP 578

  Fly   581 CKEP--EEVENIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMWWFFALMMLNSYTANLAAF 643
            |.:.  ..:.|.:|:.|:.|..:|..|.||..|.|:|.|||.|:|:||.|.|::::|||||||||
  Rat   579 CAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAF 643

  Fly   644 LTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTKTNDE 708
            ||..|....|.|.:|||.|:.|:||.:.|||:|.||::|.:.|||:||..|.|..||||.|:.:|
  Rat   644 LTVQRMEVPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEE 708

  Fly   709 GVERVQKGKNLYAFLMESTTLEYNVERKCDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLG 773
            |:.||....  ||||:|||..||..:|.|:|.||||.||.|.|||.||..|.:|.:...|:|:|.
  Rat   709 GIARVLNSN--YAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQ 771

  Fly   774 ELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVGGVFLVLGLGLLSAMVLGCTEFLWN 838
            |..:|..||||||:    ||.|.|  |:......||:||:||:|:||..||:.|:.:...||||.
  Rat   772 ENNRLEILKRKWWE----GGKCPK--EEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWT 830

  Fly   839 VKSVAIEEKISLKEAFKSE 857
            ::.....| :|:.:...:|
  Rat   831 LRHSEASE-VSVCQEMMTE 848

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	27..397	CDD:380605	85/335 (25%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	172/374 (46%)
Grik4	NP_036704.1	Periplasmic_Binding_Protein_type1	24..402	CDD:471960	85/339 (25%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	172/374 (46%)
		QRL_CxxC_CxxC	863..927	CDD:469521
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..956