DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and Grin3a

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_001263284.1	Gene:	Grin3a / 242443	MGIID:	1933206	Length:	1135	Species:	Mus musculus

Alignment Length:	1067	Identity:	221/1067 - (20%)
Similarity:	422/1067 - (39%)	Gaps:	237/1067 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 ESEIAFRTAVDRANILERNVELVPIVVYAN-----TDDSFIMEKMVCN-LISQGVIAI--FGPST 93
            |..:.:..:::....:|..:..:|::.:::     :.|.|...:.||: ::.|||.|:  |..|.
Mouse   139 EGLLPYNLSLEVVMAIEAGLGDLPLMPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQ 203

  Fly    94 GS--SSDIIASICDTLDIP--HIVYDWIPNESIPDREHSTMTLNVHPDNLLLSQGLAEIVQSFA- 153
            |.  ..|:::|:   |.||  .||....|.||     .:.:.|.:..:|.|.|.  |::..|..
Mouse   204 GEMMELDLVSSV---LHIPVLSIVRHEFPRES-----QNPLHLQLSLENSLSSD--ADVTVSILT 258

  Fly   154 ---WRSFTVVYETDKELQQLQDILQVG--------EPISNPTTVKQLGPGDDHRPF----LKEIK 203
               |.:|:::  ..:|...:.|.|.:.        |.|.|.|.  .|....|...|    |:.|:
Mouse   259 MNNWYNFSLL--LCQEDWNITDFLLLTENNSKFHLESIINITA--NLSSTKDLLSFLQVQLENIR 319

  Fly   204 LSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFGELSGVEANITTVRLMDP 268
            .||...::..|...::.:|.:.                     |..||              :.|
Mouse   320 NSTPTMVMFGCDMGSIRQIFEM---------------------STQFG--------------LSP 349

  Fly   269 SDFH-----VKNVVHDWEEREKREGRYFKVDPNRVKSQMIL---LNDAVWLFSKGLTELGIFE-- 323
            .|.|     .:||     |..:.||....:..:...:|.:.   :.||:.|.::.:....:.:
Mouse   350 PDLHWVLGDSQNV-----EELRTEGLPLGLIAHGKTTQSVFEYYVQDAMELVARAVATATMIQPE 409

  Fly   324 -ELTAPDLECRRKKPWPF--GKRIIEFIKARSEETSTGRIDFN----ENGQRSFF--TLRFMELN 379
             .|....:.|...|....  |:.:..|:...:....:|.|...    .:.:.:||  .|::..:.
Mouse   410 LALLPSTMNCMDVKTTNLTSGQYLSRFLANTTFRGLSGSIKVKGSTIVSSENNFFIWNLQYDPMG 474

  Fly   380 SDGFLDLATWDPVNGLDVLNDDEESEKRVGQKL----SNKTFI-VSSRLGAPFLTLREPQE---- 435
            ...:..|.:|.  .|..|::.....|:....|.    .||..: |.:.:..||:..||..:
Mouse   475 KPMWTRLGSWQ--GGRIVMDSGIWPEQAQRHKTHFHHPNKLHLRVVTLIEHPFVFTREVDDEGLC 537

  Fly   436 --GEI----LTGNS-------------------RYE----GYSIDLINEIAKMLNFKFEFRMSPD 471
              |::    :|.:|                   :::    ||.|||:.::|:.:||.|:..:..|
Mouse   538 PAGQLCLDPMTNDSSILDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGD 602

  Fly   472 GKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPPT 536
            |||||..  ...|.|:|..|:.|.|::.:...::.::|.|.:|||.||.:..:.||.....| ..
Mouse   603 GKYGAWK--NGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDT-AA 664

  Fly   537 DLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENPHPCKEPEEVEN-IWSIMNTTWLS 600
            .:.:|:.|....:|:     .:|::|.:.|:. :...:|::|..........| ::|..:...:.
Mouse   665 PIGAFMWPLHWTMWL-----GIFVALHITAIF-LTLYEWKSPFGMTPKGRNRNKVFSFSSALNVC 723

  Fly   601 IGSLMGQGCDIL-PKAASTRLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAED--LAAQ 662
            ...|.|:...|. ||..:.|.:..:|..|.:..|::|||||||.:...:....::...|  |...
Mouse   724 YALLFGRTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHP 788

  Fly   663 SK-IKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTKTNDEGVERVQKG-KNLYAFLME 725
            |: .::|.:...|...:.|.|....::.|......|:|        :||:.::.. :.|.||:|:
Mouse   789 SQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATP--------DGVQYLKNDPEKLDAFIMD 845

  Fly   726 STTLEY--NVERKCDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKE 788
            ...|:|  :::..|.|:.:|.....:.|||.:|.|||....||..:.:....|.:..|..||:|.
Mouse   846 KALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVLHDKWYKV 910

  Fly   789 MHGGGNCEKSDEDGGDTPELGLENVGGVFLVL--GLGLLSAMVLGCTEFLWNVKSVAIEEKISLK 851
            :    .|.|......:|.::|:::..|:|::|  |.||.....:| ...::.:....|:.|..|
Mouse   911 V----PCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIG-EHIVYRLLLPRIKNKSKL- 969

  Fly   852 EAFKSEALFAARIWITTKPVHTSSESGSSNSSSSSSSRSKHSFKSQGLSMKSLKSSGYQDVEASV 916
                       :.|:     |||...              |         ::|.:|..::.:..
Mouse   970 -----------QYWL-----HTSQRF--------------H---------RALNTSFVEEKQPC- 994

  Fly   917 HSKLKKIGSMFSLKSQKTVTPPPEIGW-----KLDKSTQIDVVPTSDV-DQELIPEVEPHLPHRH 975
             ||.|::.     ||:          |     |.:..:::.:.|.|:: .|:|:.....:|.|.:
Mouse   995 -SKTKRVE-----KSR----------WRRWTCKTEGDSELSLFPRSNMGPQQLMVWNTSNLSHDN 1043

  Fly   976 HHHHHHRHHHHHHQ-PDQEHDRNPSPP 1001
            ...:........:| ..|.|...|.||
Mouse  1044 QRKYIFNDEEGQNQLGTQTHQDIPLPP 1070

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	76/405 (19%)
		ANF_receptor	39..379	CDD:279440	72/386 (19%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	101/414 (24%)
		Lig_chan	548..812	CDD:278489	63/271 (23%)
Grin3a	NP_001263284.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	77/413 (19%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	99/412 (24%)
		Lig_chan	676..942	CDD:278489	66/283 (23%)
		PPP2CB binding site. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	951..987		10/76 (13%)
		GIT1-binding. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	1082..1115
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846249
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830