Protein Alignment clumsy and Grin3a

DIOPT Version :10

• Sequence 1: NP_001036373.1
• Gene: clumsy / 35394
• FlyBaseID: FBgn0026255
• Length: 1002
• Species: Drosophila melanogaster
• Sequence 2: NP_001263284.1
• Gene: Grin3a / 242443
• MGIID: 1933206
• Length: 1135
• Species: Mus musculus
• Alignment Length: 1067
• Identity: 221/1067 - (20%)
• Similarity: 422/1067 - (39%)
• Gaps: 237/1067 - (22%)

  Fly    37 ESEIAFRTAVDRANILERNVELVPIVVYAN-----TDDSFIMEKMVCN-LISQGVIAI--FGPST 93
            |..:.:..:::....:|..:..:|::.:::     :.|.|...:.||: ::.|||.|:  |..|.
Mouse   139 EGLLPYNLSLEVVMAIEAGLGDLPLMPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQ 203

  Fly    94 GS--SSDIIASICDTLDIP--HIVYDWIPNESIPDREHSTMTLNVHPDNLLLSQGLAEIVQSFA- 153
            |.  ..|:::|:   |.||  .||....|.||     .:.:.|.:..:|.|.|.  |::..|..
Mouse   204 GEMMELDLVSSV---LHIPVLSIVRHEFPRES-----QNPLHLQLSLENSLSSD--ADVTVSILT 258

  Fly   154 ---WRSFTVVYETDKELQQLQDILQVG--------EPISNPTTVKQLGPGDDHRPF----LKEIK 203
               |.:|:::  ..:|...:.|.|.:.        |.|.|.|.  .|....|...|    |:.|:
Mouse   259 MNNWYNFSLL--LCQEDWNITDFLLLTENNSKFHLESIINITA--NLSSTKDLLSFLQVQLENIR 319

  Fly   204 LSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFGELSGVEANITTVRLMDP 268
            .||...::..|...::.:|.:.                     |..||              :.|
Mouse   320 NSTPTMVMFGCDMGSIRQIFEM---------------------STQFG--------------LSP 349

  Fly   269 SDFH-----VKNVVHDWEEREKREGRYFKVDPNRVKSQMIL---LNDAVWLFSKGLTELGIFE-- 323
            .|.|     .:||     |..:.||....:..:...:|.:.   :.||:.|.::.:....:.:
Mouse   350 PDLHWVLGDSQNV-----EELRTEGLPLGLIAHGKTTQSVFEYYVQDAMELVARAVATATMIQPE 409

  Fly   324 -ELTAPDLECRRKKPWPF--GKRIIEFIKARSEETSTGRIDFN----ENGQRSFF--TLRFMELN 379
             .|....:.|...|....  |:.:..|:...:....:|.|...    .:.:.:||  .|::..:.
Mouse   410 LALLPSTMNCMDVKTTNLTSGQYLSRFLANTTFRGLSGSIKVKGSTIVSSENNFFIWNLQYDPMG 474

  Fly   380 SDGFLDLATWDPVNGLDVLNDDEESEKRVGQKL----SNKTFI-VSSRLGAPFLTLREPQE---- 435
            ...:..|.:|.  .|..|::.....|:....|.    .||..: |.:.:..||:..||..:
Mouse   475 KPMWTRLGSWQ--GGRIVMDSGIWPEQAQRHKTHFHHPNKLHLRVVTLIEHPFVFTREVDDEGLC 537

  Fly   436 --GEI----LTGNS-------------------RYE----GYSIDLINEIAKMLNFKFEFRMSPD 471
              |::    :|.:|                   :::    ||.|||:.::|:.:||.|:..:..|
Mouse   538 PAGQLCLDPMTNDSSILDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGD 602

  Fly   472 GKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPPT 536
            |||||..  ...|.|:|..|:.|.|::.:...::.::|.|.:|||.||.:..:.||.....| ..
Mouse   603 GKYGAWK--NGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDT-AA 664

  Fly   537 DLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENPHPCKEPEEVEN-IWSIMNTTWLS 600
            .:.:|:.|....:|:     .:|::|.:.|:. :...:|::|..........| ::|..:...:.
Mouse   665 PIGAFMWPLHWTMWL-----GIFVALHITAIF-LTLYEWKSPFGMTPKGRNRNKVFSFSSALNVC 723

  Fly   601 IGSLMGQGCDIL-PKAASTRLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAED--LAAQ 662
            ...|.|:...|. ||..:.|.:..:|..|.:..|::|||||||.:...:....::...|  |...
Mouse   724 YALLFGRTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHP 788

  Fly   663 SK-IKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTKTNDEGVERVQKG-KNLYAFLME 725
            |: .::|.:...|...:.|.|....::.|......|:|        :||:.::.. :.|.||:|:
Mouse   789 SQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATP--------DGVQYLKNDPEKLDAFIMD 845

  Fly   726 STTLEY--NVERKCDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKE 788
            ...|:|  :::..|.|:.:|.....:.|||.:|.|||....||..:.:....|.:..|..||:|.
Mouse   846 KALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVLHDKWYKV 910

  Fly   789 MHGGGNCEKSDEDGGDTPELGLENVGGVFLVL--GLGLLSAMVLGCTEFLWNVKSVAIEEKISLK 851
            :    .|.|......:|.::|:::..|:|::|  |.||.....:| ...::.:....|:.|..|
Mouse   911 V----PCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIG-EHIVYRLLLPRIKNKSKL- 969

  Fly   852 EAFKSEALFAARIWITTKPVHTSSESGSSNSSSSSSSRSKHSFKSQGLSMKSLKSSGYQDVEASV 916
                       :.|:     |||...              |         ::|.:|..::.:..
Mouse   970 -----------QYWL-----HTSQRF--------------H---------RALNTSFVEEKQPC- 994

  Fly   917 HSKLKKIGSMFSLKSQKTVTPPPEIGW-----KLDKSTQIDVVPTSDV-DQELIPEVEPHLPHRH 975
             ||.|::.     ||:          |     |.:..:::.:.|.|:: .|:|:.....:|.|.:
Mouse   995 -SKTKRVE-----KSR----------WRRWTCKTEGDSELSLFPRSNMGPQQLMVWNTSNLSHDN 1043

  Fly   976 HHHHHHRHHHHHHQ-PDQEHDRNPSPP 1001
            ...:........:| ..|.|...|.||
Mouse  1044 QRKYIFNDEEGQNQLGTQTHQDIPLPP 1070

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	27..397	CDD:380605	76/406 (19%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	101/414 (24%)
Grin3a	NP_001263284.1	PBP1_iGluR_NMDA_NR3	40..496	CDD:380600	77/412 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	59..118
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	99/412 (24%)
		Lig_chan	674..941	CDD:459656	66/284 (23%)
		PPP2CB binding site. /evidence=ECO:0000250|UniProtKB:Q9R1M7	951..987		10/76 (13%)
		GIT1-binding. /evidence=ECO:0000250|UniProtKB:Q9R1M7	1082..1115