DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment clumsy and W02A2.5

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_502564.2	Gene:	W02A2.5 / 189098	WormBaseID:	WBGene00012190	Length:	487	Species:	Caenorhabditis elegans

Alignment Length:	497	Identity:	104/497 - (20%)
Similarity:	203/497 - (40%)	Gaps:	98/497 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   445 YEGYSIDLINEIAKMLNFKFEFRMSP-------DG-KYGALNKVTQTWDGIVRQLIDGNADLGIC 501
            :.|:::    |:.||:....::.:.|       .| .:|.|.| ..||.|::..|.:|.||....
Worm    36 FPGWTM----EVLKMITDSLKWEIIPVVTPTIVGGLDWGTLQK-NGTWSGVLGYLQNGTADAVAL 95

  Fly   502 DLTMTSSRRQAVDFTPPFMTL-GISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLF 565
            ....|.:|.:..:::.|...: .:.:...|..|..:.|::...|||::||:.:.::.:...|::.
Worm    96 MYQKTDTRNEYFEYSYPVTNVQPVFVARKKTETLGSVLWNAFKPFSVEVWLCLLASLVLNLLIMI 160

  Fly   566 AL----------ARMAPDDWENPHPCKEPEEVENIWSIMNTTWLSIGSLMGQGCDILPKAASTRL 620
            |:          :|..|  |            |.:|.::..      .|..:..|:|....|..:
Worm   161 AISGIEFKLLFRSRFRP--W------------EMLWHVVQL------QLDEKSDDMLFYTLSGNI 205

  Fly   621 VTGMWWFFALM----MLNSYTANLAAFLTNSRQANSINSAEDLAAQ-SKIKYGAMAGGSTMGFFR 680
            |.   :.|||:    ::..|...|...|..|...|...:|:::... .:.||..........:|.
Worm   206 VL---FVFALLQSGILIEVYKGMLLTALITSNGDNPFANADEMIKLIGEKKYHLTTNYMGNWYFD 267

  Fly   681 DSNFSTYQKMWT--AMESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVERKCDLVQIG 743
            |...|..|...:  |..:::|.:...:....::.|..||.:|....:|..::.:.|| |:.|
Worm   268 DLQHSDQQHFVSLRAATASNPVIPAASVSAALDLVDSGKYIYPIQQDSLAMQMSKER-CNYV--- 328

  Fly   744 GWLDYKSYGIAMPFNSPYRKQISAAVLKLGELGQLAE-----------LKRKWWKEMHGG----- 792
                |.|.|  ||       |:|:..:.......:||           ::|.:.|..:.|
Worm   329 ----YVSDG--MP-------QVSSFFVFTKNFSGIAEFNTQIIMNQAFIQRTFNKYFNEGFKLGF 380

  Fly   793 -GNCEKSDEDGGD-TPELGLENVGGVFLVLGLGLLSAMVLGCTEF--LWNVKSVAIEEKISLKEA 853
             ..||.::....| |..|.:|:|.|||.:..||:.:::::...|.  .|:|:.:|  .:..:::.
Worm   381 IPKCEVTEPTASDATKPLDIESVIGVFTIGALGVAASLMVFVFEIYHYWHVRILA--RRARMRDP 443

  Fly   854 FKSEALF-AARIWITTKPVHTSSE----SGSSNSSSSSSSRS 890
            :....|. .|:|..||...::..:    ..:.|::||||..|
Worm   444 WNVRNLARIAQIHFTTHEQYSDIDVMRLVDAFNATSSSSDTS 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377
		ANF_receptor	39..379	CDD:279440
		PBP2_iGluR_Kainate	414..787	CDD:270432	75/378 (20%)
		Lig_chan	548..812	CDD:278489	57/298 (19%)
W02A2.5	NP_502564.2	Lig_chan-Glu_bd	<36..86	CDD:214911	12/54 (22%)
W02A2.5	NP_502564.2	Periplasmic_Binding_Protein_Type_2	<74..>124	CDD:304360	11/50 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810