DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and glr-6

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_741822.2	Gene:	glr-6 / 180955	WormBaseID:	WBGene00001617	Length:	844	Species:	Caenorhabditis elegans

Alignment Length:	890	Identity:	250/890 - (28%)
Similarity:	416/890 - (46%)	Gaps:	121/890 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYSLFLTHFLLIALPVLADIDRSQFMVGSIFTSDKDESEIAFRTAVD----RAN---ILERNVEL 58
            |.::|  .|||::   ......|...:| :.||...|..:  ||||:    |.|   :..|....
Worm     1 MLNIF--RFLLLS---FLGTGVSSIRIG-LITSHHLEHSV--RTAVNIIVPRINEQIVKTRGACF 57

  Fly    59 VPIVVYANTDDSFI--------MEKMVCNLISQGVIAIFGPSTGSSSDIIASICDTLDIPHIVYD 115
            :       |..|||        :...:|:|.:..|..|.|.....|..||...|..|:|..|.|.
Worm    58 I-------THTSFIALKNSHEDLNTKICDLANSEVSVIIGVVDRESGSIIEEQCAELNILFIHYY 115

  Fly   116 WIPNESIPDREHSTMTLNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEPI 180
            |.|..    ::....:||::| ::..||.:..::..:.|.:|..:|......:||.:.|...|
Worm   116 WTPGY----QKKQQTSLNLYP-SMEYSQLMERLINLWRWDNFVYIYSNYDAPKQLIETLSRLE-- 173

  Fly   181 SNPTTVKQLGPGDDHRPFLKEIKLSTD--------NCLILHCAPDNLLKILQQANELKMLGEYQS 237
            .:|..::.....|........::.:.|        |.:::..:|:..|.....:.:|.|:..:..
Worm   174 KSPALLRAHTLDDSMMATALALRDTCDRNRCWPKKNRVLIELSPNETLTFFDASLKLGMISVHNW 238

  Fly   238 VFIPLLD---------THSIDFGELSGVEANITTV--RLMDPSDFHVKNVVHDWEEREKREGRYF 291
            ..|..||         ||       :|:..::.||  ...:.:|..:|  :.|..:      .|.
Worm   239 FLITALDDLNDHLSQYTH-------NGMRVSLLTVSKEKWNQNDLAIK--LPDMYQ------EYL 288

  Fly   292 KVDPNRVKSQMILLNDAVWLFSKGL--TELGIFEELTAPDLECRRKKPWPFGKRIIEFIKARSEE 354
            ...|:..::.   ..|..::|...|  .:.|....::..|.|..:|...|    |::..|.
Worm   289 AKIPSNPRTP---FKDFAFIFDSILLACQAGDRRIISCGDNEAVKKFKLP----IVKPFKG---- 342

  Fly   355 TSTGRIDFNENGQRSFFTLRFMELNSDGF-----LDLATWDPVNGLDVL--NDDEESEKRVGQKL 412
             .||:|.||....||...|...|:...|.     :..:||:....|.:|  |.....|.......
Worm   343 -LTGKISFNGTSDRSDSELHIWEMGITGAGLHTGIWKSTWEGSKELTMLAKNIPGTHEHYQASVR 406

  Fly   413 SNKTFIVSSRLGAPFLTLREPQEGEILTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGAL 477
            .::|..|:|....|::..:...:|.|     ::||:.:||::::|:||:|.:..::..|.|||..
Worm   407 ESRTLKVTSIHEKPYVIEKIMPDGRI-----KHEGFCVDLLDKLAEMLHFNYTLKIVKDNKYGER 466

  Fly   478 NKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSKP-PTPPTDLFSF 541
            ...|..|||::.:::.|:||:.:..:|:|::|.:.:|||.||:.||||:|..:| |...:.|..|
Worm   467 KNGTDEWDGMIGEILRGDADMAVAPITVTATRLEVIDFTDPFLQLGISMLMRQPNPKSSSSLTRF 531

  Fly   542 LSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENPHPCKEPEEVENIWSIMNTTWLSIGSLMG 606
            |.|.|..||.:...|.:..:||:...|.::            |:|....:.|.|:.|..:..|:.
Worm   532 LWPLSASVWTFSAIATVITALLVTVAAVLS------------PKESTAEFKIQNSVWYLVCILLR 584

  Fly   607 QGCDILPKAASTRLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMA 671
            .|.....:|.:|||::.:||.|.|:::..||||.||.||..|::...||.|:|..|::..:|::.
Worm   585 AGSGYNCQAGATRLISAVWWSFTLVLIAQYTANFAALLTVDRKSMPFNSFEELGNQTEYNFGSIL 649

  Fly   672 GGSTMGFFRDSNFSTYQKMWTAMESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVERK 736
            |||||.||:.|...|::::|..|:||.||.|..||.|||.||...|  |.|||||.||:|.|.:.
Worm   650 GGSTMQFFKYSRIETFRRLWERMQSAEPSAFVGTNHEGVNRVLNEK--YVFLMESATLDYQVTQN 712

  Fly   737 CDLVQIGG-WLDYKSYGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDE 800
            |:|.::|. .|....|.||:|..|.:|::::..:|.|.|.|.:..||..|||:..  ..|:.|:.
Worm   713 CNLTRVGNVVLGSNGYSIALPKGSKWREKLTRQILDLNEKGIILMLKNNWWKKSQ--QECQSSEP 775

  Fly   801 DGGDTPELGLENVGGVFLVL----GLGLLSAMVLGCTEFLWNVKS 841
            :...| .||.|||.|:||:|    |:|:|.| ||..|.|::..|:
Worm   776 EDLQT-ALGAENVYGLFLLLALGSGIGVLCA-VLEHTHFIFFEKN 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	85/410 (21%)
		ANF_receptor	39..379	CDD:279440	78/375 (21%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	132/374 (35%)
		Lig_chan	548..812	CDD:278489	94/264 (36%)
glr-6	NP_741822.2	PBP1_iGluR_non_NMDA-like	21..394	CDD:380591	87/416 (21%)
glr-6	NP_741822.2	PBP2_iGluR_Kainate	409..764	CDD:270432	132/373 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020