DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and glr-5

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_505244.1	Gene:	glr-5 / 179251	WormBaseID:	WBGene00001616	Length:	932	Species:	Caenorhabditis elegans

Alignment Length:	928	Identity:	260/928 - (28%)
Similarity:	446/928 - (48%)	Gaps:	103/928 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 FMVGSIFTSDKD-ESEIAFRTAVDRANILERNV--ELVPIVVYANTDDSFIMEKMVCNLISQG-V 85
            :.:|:||...:| ..|.|.|.:|:.  :.:|.:  ::..::.|.:..|.:...|..|.::.:. :
Worm    25 YKIGAIFREREDAHIEAAVRYSVEW--LSQRGIYGDIDLVIEYIDVLDHYDAIKKACKMLEKDHI 87

  Fly    86 IAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESIPDREHSTMTLNVHPDNLLLSQGLAEIVQ 150
            :|:.|.|..:.:..:..|.|.||||.:.   ..::...|...|.:.....|.   |.:.:.::..
Worm    88 VALLGGSHAALNAQLERITDDLDIPFLT---AIDDLRTDMGKSKIDFWPRPQ---LFEAVVDMFT 146

  Fly   151 SFAWRSFTVVYETDKELQQLQDILQVGEPISNPTTVKQLGPGDDHRPFLKEIKLSTDNCLILH-- 213
            .:.|....:|||.|:.:::|:.:|:..|..|....:.::..| |:....:::| ..:.|.:||
Worm   147 HWRWNRIVLVYEGDERIRRLEQLLESEEYASIRFYLIKVHDG-DYMKAARQVK-ELEECRLLHKK 209

  Fly   214 -CAPDNLLKILQQANE----LKMLGEYQSVFIPLLDTHSIDFGELSGVEANI---TTVRLMDP-- 268
             |:  ...::|...|.    ..:|...|...|.|.....:...|||.::..:   ...|.:.|
Worm   210 DCS--EFSRLLVDMNPEHTYTFLLASLQMGLIELKHWFLLTNMELSTMDMELFRYNHARFISPYP 272

  Fly   269 --SDFHVKN------------VVHDWEEREKREGRYFKVDPNRVKSQM--ILLNDAVWLFSKGLT 317
              |.|..:|            :...|.         .|.|.:|....|  :...|||:.|:....
Worm   273 VDSTFLTENRDAFNFSHFKEHITEKWA---------MKTDNSRNLKMMEAVFTFDAVYAFANVFN 328

  Fly   318 ELGIFEELT-APDLECRR----KKPWPFGKRIIEFIKARSEETSTGRI-DFNENGQRSFFTLRFM 376
            ||....::. .|...||:    .:.:..|:.:|:.|........:|.: ..|.:..:|.|::|..
Worm   329 ELSSHMQMNDVPQTLCRKSSRNSRKYQHGRSLIDNIVHNDLHGLSGDLRRLNGHPLKSNFSMRIQ 393

  Fly   377 ELNSDGFL-DLATWDPVNGLDV-LNDDEESEKRVGQKLSNKT---FIVSSRLGAPFLTLREPQEG 436
            .|...|.| |:..|:|...:.| ::.|.:::.:...::|::.   |.|::.:..|::.|::....
Worm   394 LLGYSGRLDDIGFWEPATNVHVNMSGDSKAQLQRNVQVSDELKPHFRVTTIMERPYVMLKKNHYE 458

  Fly   437 EILTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGIC 501
              |..||::||:.|||:.|::|.|.|.:......|||||.......:|||::.:::.|.|::.:.
Worm   459 --LDANSKFEGFCIDLLAELSKDLGFTYTIHAVKDGKYGNDKYGNGSWDGMMGEILRGEAEMAVA 521

  Fly   502 DLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFA 566
            .||:...|.:|||||.||::||||||:..|.....||||||:|.|..:|..:.::.:.::|.::.
Worm   522 PLTVNYRRSEAVDFTKPFLSLGISILYKVPDDQQPDLFSFLNPLSWQIWTAIATSIITVTLGMYF 586

  Fly   567 LARMAPDDW---------ENPHPC-------KEPEEVENIWSIMNTTWLSIGSLMGQGCDILPKA 615
            :|.:.|.:|         ..|||.       :.|..:.|.:|..||.|..:.:::..|||..|:|
Worm   587 VANVTPYEWNLNFSCCTAHEPHPAAAFATNQEAPIVMSNNYSFWNTVWYVLSTMLKGGCDFGPRA 651

  Fly   616 ASTRLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFR 680
            .||||:.|.||.|.|:::::|||||||.||.||....|.:.:|||.|:.|.||.:.|||||.||:
Worm   652 VSTRLLGGTWWVFYLVIISAYTANLAAVLTVSRPYIPIKNLDDLANQTTISYGTIRGGSTMQFFQ 716

  Fly   681 DSNFSTYQKMWTAMESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVERKCDLVQIGGW 745
            :|..:.:.|||..|:  ...||..:|.:||||.....  ||:|||||:|||..::.|:|.||||.
Worm   717 ESRIAAHVKMWQYMK--DKDVFVTSNGKGVERALSMN--YAYLMESTSLEYETQQNCNLTQIGGV 777

  Fly   746 LDYKSYGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGL 810
            |..|.||||:...|.:..:||..:|...:.|.:...|.|||:. .|......:.....|...|.:
Worm   778 LGSKGYGIALAKKSEWTDRISRQILLYAKRGIIEMKKTKWWRS-KGAACASTASAVKHDRFALSM 841

  Fly   811 ENVGGVFLVLGLGLLSAMVLGCTEFLWNVKSVAIEEKISLKEAFKSEALFAARIWITTKPVHTSS 875
            .||.|:|:.||:|::.|.::...|.:.....:|.:|    .:.|..|.|:..|..:
Worm   842 YNVAGLFITLGVGIVLAAIVVIFELIHRCHHIAKKE----GKPFLEELLYELRFAL--------- 893

  Fly   876 ESGSSNSSSSSSSRSKHS 893
               :.||.|...||.|.|
Worm   894 ---NMNSLSDHRSRQKMS 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	84/408 (21%)
		ANF_receptor	39..379	CDD:279440	74/376 (20%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	147/391 (38%)
		Lig_chan	548..812	CDD:278489	100/279 (36%)
glr-5	NP_505244.1	PBP1_iGluR_delta_like	26..418	CDD:107376	85/412 (21%)
		ANF_receptor	38..377	CDD:279440	70/359 (19%)
		PBP2_iGluR_Kainate	438..819	CDD:270432	147/386 (38%)
		Lig_chan	568..855	CDD:278489	106/291 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I4290
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		otm14234
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.780