DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and glr-1

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_498887.2	Gene:	glr-1 / 176204	WormBaseID:	WBGene00001612	Length:	962	Species:	Caenorhabditis elegans

Alignment Length:	943	Identity:	271/943 - (28%)
Similarity:	430/943 - (45%)	Gaps:	153/943 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 FTSD--KDESEIAFRTAVDRANILERNVELVPIVVYANTDDSFIMEKMVCNLISQGVIAIFGPST 93
            :|||  ....::.|:.|.|. .::|....:           |:.|...||:.:.:|.:|:.....
Worm    51 YTSDHINSRDDVPFKLAFDH-RVVEEGAAV-----------SWNMVNAVCDELKEGAMALLSSVD 103

  Fly    94 GSSSDIIASICDTLDIPHIVYDWIPNESIPDREHSTM-TLNVHPDNLLLSQGLAEIVQSFAWRSF 157
            |...:.|..:.|.|::|.:....:.|:....::...: .::|.|.   :|:.||:.:....|...
Worm   104 GKGREGIRGVSDALEMPLVSLTALSNDDHQQQQFGNLFEVSVRPP---ISELLADFIVHKGWGEV 165

  Fly   158 TVVYE---TDKELQQLQDILQVGEPISNPTTVKQLGPGDDHR--PFLKEIKL---STDNCLILHC 214
            .|:.:   ....|..|...|:.....|...::..| |.|:.:  .:|.:..:   :..|.:::.|
Worm   166 LVLIDPVHASLHLPSLWRHLRTRTNTSVKASMFDL-PADEKQFEAYLMQFNMMRNNETNRILIDC 229

  Fly   215 A-PDNLLKIL--------QQANELKMLGEYQSVFIPLLDTHSIDFGELSGVEANI---------- 260
            | |..|.|:|        .|||...:|..|.  |:| .|......|.::....||
Worm   230 ASPKRLKKLLINIRSAQFNQANYHYVLANYD--FLP-YDQEMFQNGNINISGFNIINKDGREYWS 291

  Fly   261 ------TTVRLMDPSDFHVKNVV-HD-----WEEREKREGRYFKVDPNRVKSQMILLNDAVW--- 310
                  |:..|....|..|:..| ||     |....|                .:..||:::
Worm   292 LKKHLKTSSSLGGGDDVSVEAAVGHDAMLVTWHGFAK----------------CLQANDSLFHGT 340

  Fly   311 -----LFSKGLTELGIFEELTAPDLECRRKKPWPF-----GKRI-IEFIKAR---SEETSTGRID 361
                 .|::|      |..:....|..|.....||     ||.| :.|...:   .|.|.||.|:
Worm   341 FRHRRFFNRG------FPGIYCDPLSDRSHPNRPFSSFEHGKTIGVAFRNMKIGHKEGTLTGNIE 399

  Fly   362 FNENGQRSFFTLRFMELNSDGFLDLATWDPVNGLDVL------------NDDEESEKRVGQKLSN 414
            |:..|.|..|.:..::|.|:      |....|..:||            ...:.|.|.......|
Worm   400 FDRFGNRKNFDVSIVDLVSN------TKATFNSKEVLAWRQGVGFFSNRTVAQHSRKSQNDHKDN 458

  Fly   415 KTFIVSSRLGAPFLTL-REPQEGEILT---GNSRYEGYSIDLINEIA-KMLNFKFEFRMSPDGKY 474
            :. ||.:.|.|||:.: ||..|...||   ||:::||:.|||:..:| |:..|.:|.::   |..
Worm   459 QV-IVLTNLVAPFVMIKRECLEMANLTECQGNNKFEGFCIDLLKLLADKIEEFNYEIKL---GTK 519

  Fly   475 GALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPPTDLF 539
            ....:...:|||::.:|:.|.|...:..||:...|.:.|||:.||||.||||:..||......:|
Worm   520 AGSKQADGSWDGMIGELLSGRAHAVVASLTINQERERVVDFSKPFMTTGISIMIKKPDKQEFSVF 584

  Fly   540 SFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENPHPCKEPEEVENIWSIMNTTWLSIGSL 604
            ||:.|.|.::|:|:..||:.:|:::|.::|.:|.:|......:....:.|.:|:.|..|.::.:.
Worm   585 SFMQPLSTEIWMYIIFAYIGVSVVIFLVSRFSPYEWRVEETSRGGFTISNDFSVYNCLWFTLAAF 649

  Fly   605 MGQGCDILPKAASTRLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGA 669
            |.||.||||::.|.|:.:..||||.:::::|||||||||||..:....|.|.||||.|||||||.
Worm   650 MQQGTDILPRSISGRIASSAWWFFTMIIVSSYTANLAAFLTLEKMQAPIESVEDLAKQSKIKYGI 714

  Fly   670 MAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEY-NV 733
            ..||||..||:.|:...||:||..|||..|.||..:..||:|||:..|..||||:|:|..|| |.
Worm   715 QGGGSTASFFKYSSVQIYQRMWRYMESQVPPVFVASYAEGIERVRSHKGRYAFLLEATANEYENT 779

  Fly   734 ERKCDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKS 798
            .:.||.:::|..|:...||||.||.|.::..|:.|:|.|.|.|:|.:|:.|||   :..|.|:..
Worm   780 RKPCDTMKVGANLNSIGYGIATPFGSDWKDHINLAILALQERGELKKLENKWW---YDRGQCDAG 841

  Fly   799 DEDGGDTPELGLENVGGVFLVLGLGLLSAMVLGCTEFLW---------NVKSVAIEEKISLKEAF 854
            ....|.:..|.|..|.|:|.:|..|::.:|:....|||:         |..|:......:||.|.
Worm   842 ITVDGSSASLNLSKVAGIFYILMGGMVISMLAALGEFLYRSRIEARKSNSNSMVANFAKNLKSAL 906

  Fly   855 KSEALFAARIWITTKPVHTSSESGSSNSSSSSS 887
            .|:             :..|.|.|:.....|.|
Worm   907 SSQ-------------LRLSVEGGAVAQPGSQS 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	87/423 (21%)
		ANF_receptor	39..379	CDD:279440	80/396 (20%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	154/378 (41%)
		Lig_chan	548..812	CDD:278489	109/264 (41%)
glr-1	NP_498887.2	PBP1_iGluR_AMPA	10..439	CDD:107375	89/434 (21%)
		ANF_receptor	44..417	CDD:279440	83/406 (20%)
		Periplasmic_Binding_Protein_Type_2	457..832	CDD:304360	153/378 (40%)
		Lig_chan	593..867	CDD:278489	113/276 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820