DRSC/TRiP Functional Genomics Resources

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Protein Alignment clumsy and glr-2

DIOPT Version :9

Sequence 1:NP_001036373.1 Gene:clumsy / 35394 FlyBaseID:FBgn0026255 Length:1002 Species:Drosophila melanogaster
Sequence 2:NP_001021114.1 Gene:glr-2 / 175999 WormBaseID:WBGene00001613 Length:977 Species:Caenorhabditis elegans


Alignment Length:880 Identity:264/880 - (30%)
Similarity:413/880 - (46%) Gaps:153/880 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    73 MEKMVCNLISQGVIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESI---PDREHSTMTLNV 134
            :.:::|:.:..|.:.:...:...:..|...|.:.:.:|.|  ||.|::|.   ...|::.|..:|
 Worm    82 LNRIICDEMKLGYMLMLAGTNFKNYGIYEDIANHMKMPLI--DWEPSKSENIGKTTENNPMIFSV 144

  Fly   135 HPDNLLLSQGLAEIVQSFAWRSFTVVYE---TDKELQQLQDILQVGEPISNPTTVKQLGPGDDH- 195
            .|.   ..|.|.:.:|...||....:::   .|:.|:.:...|....|.........:.|.|:. 
 Worm   145 APS---AEQLLIDYIQYKGWRDVVYIHDGKNADRTLRTMFSYLHEKSPKYQLFVDNYVAPSDEEM 206

  Fly   196 -RPFLKEI--KLSTDNCL--------ILHCAPDNL-------------LKILQQANELKMLGEYQ 236
             :.||.|.  ::||.:.|        |....|.|:             |:.|:::..:|.  ||.
 Worm   207 FKEFLNEFHRRISTQHTLKSNDSSEEIDEPIPVNVIVDLEGSYRTRAFLRALEESVLVKK--EYH 269

  Fly   237 SVFIPLLDTHSIDFGELSGVE---ANITTVRLMDP---------SDFHVKNVVHDWEEREKREGR 289
            .||    ....:|..:|||..   .|||..|:.|.         ::||           :...|.
 Worm   270 YVF----SNFDVDETDLSGFHFSLINITIFRIFDKNNKKFLKTRAEFH-----------DVYRGG 319

  Fly   290 YFKVDPNRVKSQMILLNDAVWLFSKGLT------ELGIFEELTA------------------PDL 330
            :...|  .:.:.....:||:.:..|.|.      ..|||::...                  ...
 Worm   320 FSNTD--SIPTAAAFAHDAILVAGKALQIAMNEHGKGIFDKSFVRHQLFNRGRKGLYCRPHEDQT 382

  Fly   331 ECRRKKPWPFGKRIIEFIK----ARSEETSTGRIDFNE-NGQRSFFTLRFME-------LNS--- 380
            |.|:.:.:..||:|.|.||    ...:.|.||||.|:: .|:|:.|:...:|       |||   
 Worm   383 ESRQFETFEHGKKIAEAIKKVVLTDKDGTLTGRIQFDKVTGKRTNFSAEIVEIKPGVNSLNSIWE 447

  Fly   381 -------DGFLDLATWDPVNGLDVLND--DEESEKRVG---QKLSNKTFIVSSRLGAPFLTL--R 431
                   :|||       :.|...:.:  .:.|:.|.|   .|.....|.|.:.|..||:.|  |
 Worm   448 RFQWAE
GEGFL-------LGGERYVQEKKKDSSQTRKGILPSKPWQLRFNVVTVLVKPFVMLKRR 505

  Fly   432 EPQEGEILTGNSRYEGYSIDLINEIAK-MLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGN 495
            .|.|.| |.||.|:|||.|||:|.:|| :..|:::..:|...|||: .:...:|||::..|::..
 Worm   506 NPGEPE-LKGNDRFEGYCIDLLNLLAKNITGFEYDVFISDGNKYGS-RQADGSWDGMIGYLLNET 568

  Fly   496 ADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFI 560
            ||:.:..||:|..|.:||||:.||||.||||:..||.....::|||:.|..:.:||:..|:|..:
 Worm   569 ADVAVAPLTITQERERAVDFSKPFMTTGISIMIKKPEKQEFNIFSFMEPLGMTIWIFTLSSYFGV 633

  Fly   561 SLLLFALARMAPDDWENPHPCKEPE-EVENIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGM 624
            ||.:|.::..:|  :|.....|..| .|.|.:::.|:.|.::.:.|.||.||||:|.|.|:.:..
 Worm   634 SLTIFLVSWFSP--YEKRIEFKRGEFTVTNEFTLYNSLWFTLAAFMQQGTDILPRAVSGRIASSC 696

  Fly   625 WWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQK 689
            ||||.|::::|||||||||||..|....|.|.||||.|:||.||...||||..||.||....|:|
 Worm   697 WWFFTLIIVSSYTANLAAFLTLERMTPPIESVEDLANQNKILYGVNEGGSTAAFFEDSIVPLYKK 761

  Fly   690 MWTAM----------------ESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVERK-C 737
            ||..|                .|.|..:|..:..:|:|:|:..|..||||:|.||..|...|: |
 Worm   762 MWNFMVSTTQKQIELEKQSITNSTSNRIFVSSYADGIEKVRTSKGKYAFLLEETTNNYESGRRPC 826

  Fly   738 DLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDG 802
            |.:::|..|:...||||....:|.|..::.|:|.|.|.|:|.:|:.|||   :..|.|:....||
 Worm   827 DTMKVGQNLNTLGYGIATKIGNPLRVSLNLAILYLSEKGELKKLENKWW---YDRGQCDTGTSDG 888

  Fly   803 GDTPELGLENVGGVFLVLGLGLLSAMVLGCTEFLW 837
            |.:..|.|..|.|:|.:|..|::.:|.....|||:
 Worm   889 GTSSSLNLSKVAGIFYILLAGMVLSMCTALVEFLF 923

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
clumsyNP_001036373.1 PBP1_iGluR_Kainate 26..396 CDD:107377 86/411 (21%)
ANF_receptor 39..379 CDD:279440 79/384 (21%)
PBP2_iGluR_Kainate 414..787 CDD:270432 157/393 (40%)
Lig_chan 548..812 CDD:278489 109/281 (39%)
glr-2NP_001021114.1 Periplasmic_Binding_Protein_Type_1 7..453 CDD:299141 82/394 (21%)
Periplasmic_Binding_Protein_Type_2 491..875 CDD:304360 155/387 (40%)
Lig_chan 621..910 CDD:278489 113/293 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG60082
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000021
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100167
Panther 1 1.100 - - O PTHR18966
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.920

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