DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and glr-4

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_001254126.1	Gene:	glr-4 / 174258	WormBaseID:	WBGene00001615	Length:	951	Species:	Caenorhabditis elegans

Alignment Length:	967	Identity:	308/967 - (31%)
Similarity:	467/967 - (48%)	Gaps:	169/967 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLIALPVLADIDRSQFMVGSIFTSDKDESEIAF---RTAVDRANI-----LERNVELVPIVVYAN 66
            ||:...:.......:|.:|:|    .:....|:   |.|:||.|.     .:....:|..:.|.|
Worm    14 LLVIFYIANSAADDRFHIGTI----ANRGSFAYEHLRYAIDRWNTEHGAHTQIKFSIVSPIRYDN 74

  Fly    67 TDDSFIMEKMVCNLISQGVIAIFGPSTGSSSD--IIASICDTLDIPHIVYDWIPNESIPDREHST 129
            .     .|:.:|.::.||::|:...:..|..|  :|.|:|...:||.:.   :.:.|:.|.....
Worm    75 N-----YEERMCEIMQQGIVAVVLSNEESEQDSQLIKSMCHYFNIPCLS---LQSTSLRDSVSDF 131

  Fly   130 MTLNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEPISN-----PTTVKQL 189
            :|| :.|.....::..:|.:.|..|..|.:.|:...:|:.|..::|..:.:..     ...:::|
Worm   132 VTL-LGPSRGAGARATSEFLDSMRWTGFLLAYQHGSDLEDLSPLMQYKQIVDTGGRRIHIKIRRL 195

  Fly   190 GPG--DDHRPFLKEIK--LSTDNCLILHCAPDN---LLKILQQANELKML-GEYQSVF----IPL 242
             |.  ||:.||||.:|  |...| :|:|  .:|   |..:||||..|.|. ..:..||    :.|
Worm   196 -PNNTDDYEPFLKYVKTRLKQTN-IIIH--SNNITVLYNLLQQARGLNMAEPPFSYVFTNTDLSL 256

  Fly   243 LDTHSIDF-GELSGV--EANITTVRLMDPSDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMIL 304
            |:    || ..:.|.  ..|||.::|       |||                  || .:|:|:.|
Worm   257 LE----DFLNNMYGASFHCNITGLQL-------VKN------------------DP-MMKTQLAL 291

  Fly   305 LNDAVWLFSKG---LTELGIFEELTAP---DLECRRKKPWPFGKRIIEFI-KARSEETSTGRIDF 362
            .::||::....   :.|||     .||   .:.|.....|..|:.:.|.| |.:.....||.:.|
Worm   292 TSEAVYVVGMSIYRMRELG-----HAPRQSSIMCDSHDIWSDGRIMNEGIRKLKLRNQLTGDVQF 351

  Fly   363 NENGQRSFFTLRFMELNSDGFLDLATWDPVNG------------LDVLNDDEESEKRVGQKLSNK 415
            ..||:|.......:...:..|:.|..|....|            .|:   |.:||...|..|.
Worm   352 KSNGERDDIMYHGVGRINSQFVKLGNWSEKRGWNFDSRYANRWEFDI---DPDSEDLEGLHLR-- 411

  Fly   416 TFIVSSRLGAPFLTLREPQEGEILTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKV 480
               |...|..||:         |.||.::|||:.|||:||:.::|.|.:......||.|| :...
Worm   412 ---VVVYLEEPFV---------IKTGENQYEGFCIDLLNEMTQVLKFNYTIIEVQDGTYG-IEDE 463

  Fly   481 TQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSK--PPTPPTDLFSFLS 543
            :..|:||:..|....|||.:..:|:|.||.:.||||.|||.||||||.::  ..|....|::||.
Worm   464 SGRWNGIIGALQRHEADLSLSAVTITYSRAEVVDFTLPFMHLGISILLARTSEETDKGSLWTFLE 528

  Fly   544 PFSLDVWIYMGSAYLFISLLLFALARMAPDDWENPHPCKEPEEVENI------WSIMNTTWLSIG 602
            |.||.|||.:..:|..:|..:..||:.:|.:|.|.....| .:.|||      ::::|:.|.::|
Worm   529 PLSLTVWISLLISYCIVSYSMHILAKFSPYEWYNLERIDE-RDFENIKNQKNQFTVLNSFWFTMG 592

  Fly   603 SLMGQGCDILPKAASTRLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKY 667
            |||.||.|::|:||:|||:..:||.|..::::||||.||||||..|.:..|.|.:|||.|.||:|
Worm   593 SLMQQGSDVIPRAAATRLIAVVWWMFTQIIISSYTAQLAAFLTVERMSTPIESTQDLANQQKIRY 657

  Fly   668 GAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYN 732
            |.:..||||.|||:|....|::||:.|||:||.||..::.||:.||:.|.  ||::|||:.|||.
Worm   658 GVLKSGSTMDFFRESKIPMYERMWSVMESSSPGVFVNSSREGIARVKSGG--YAYMMESSMLEYY 720

  Fly   733 VERKCDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNC-- 795
            :||.|:|..|||.||.|.||||:|..||.|..:|..||:|.|...|..||.|||::...|.:|
Worm   721 LERDCELQSIGGLLDSKGYGIALPKGSPLRDILSRTVLQLQERTILEALKNKWWRDRREGPSCGP 785

  Fly   796 EKSDEDGGDTPELGLENVGGVFLVLGLGLLSAMVLGCTEFLWNVKSVAIEEKISLKEAFKSEALF 860
            ..|::.....|    :|:.|:|.||..||:.|.:|.|.|:       .||   |..|||:.:...
Worm   786 PPSEKATNSKP----QNIFGIFYVLLTGLIVAFLLACGEY-------CIE---SRHEAFRLKLTI 836

  Fly   861 AARI--WITTKPVHTSSESGSSNSSSSSSSRSKHSFKSQGLSMKSLKSSGYQDVEAS 915
            ..:.  |.          .|:||   .|..|||       |....|.::| |:|..|
Worm   837 VGKFMDWY----------RGNSN---DSKQRSK-------LRNMQLDTAG-QEVSIS 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	99/418 (24%)
		ANF_receptor	39..379	CDD:279440	93/376 (25%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	164/380 (43%)
		Lig_chan	548..812	CDD:278489	117/271 (43%)
glr-4	NP_001254126.1	PBP1_iGluR_Kainate	30..385	CDD:107377	99/406 (24%)
		ANF_receptor	45..365	CDD:279440	92/367 (25%)
		Periplasmic_Binding_Protein_Type_2	410..775	CDD:304360	165/382 (43%)
		Lig_chan	533..810	CDD:278489	122/283 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		otm14234
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.930