DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and glr-3

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_492017.3	Gene:	glr-3 / 172449	WormBaseID:	WBGene00001614	Length:	836	Species:	Caenorhabditis elegans

Alignment Length:	801	Identity:	267/801 - (33%)
Similarity:	422/801 - (52%)	Gaps:	88/801 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 VCNLISQGVIAIFGPSTG----SSSDIIASICDTLDIPHIVYDWIPNESIPDREHSTMTLNVHPD 137
            |||.:..|..||..|...    :::.|:.||.|..::|.:.....|    |.|.    :.::||.
Worm    75 VCNCLILGASAIILPEQYDGHLAAAAIVQSIADNTNVPCVSLHLSP----PTRP----STHLHPH 131

  Fly   138 NLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVG--EPISNPTTVKQLGPGDDHRPFLK 200
            ....|..:|..::...|:...||:|...||.::.|::..|  :|.|..:.:.:|..|||:...||
Worm   132 LNAKSLAVAAFIKREKWKDVVVVFEEPDELLEITDMITAGHFDPDSFSSQLVRLKHGDDYGNELK 196

  Fly   201 EIKLSTDNC-LILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFGELSGVE-ANITTV 263
            .||...|.. ::::......|..|:||..:.|.|......:..:|..::|...:.|:| .|||:.
Worm   197 HIKNKLDRYRIVINIPLQKALHFLEQAANMSMCGVLYHYVVMDMDLVTVDIDSIRGIEDCNITSF 261

  Fly   264 RLMDPSDFHVKN----VVHDWEEREKREGRYFKVDPNRVKSQMILLNDAVW-----LFSKGLTEL 319
            .:.|.:..::::    :||....|..::|              :....::|     |..:.:..:
Worm   262 GVHDVNSEYIEDIRQEIVHKSSIRLPKKG--------------VPYTTSIWIDTLRLLIRSMKSI 312

  Fly   320 GIFEELTAPDLECRRKKPWPFGKRIIEFIKARSEETS----TGRIDFNENGQRSFFTLRFMELNS 380
            .|::|   |    |....|..|..    ||.|..|..    :|.:.:..:|:||.:||.... .:
Worm   313 QIWDE---P----RCGSSWKSGSD----IKKRFFENPLAGISGDLHWAPSGERSNYTLHVYR-RT 365

  Fly   381 DGFLDLATWDP----VNGLDVLNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLREPQEGEILTG 441
            ..|...|.|..    :...:.:.....|||..   |..|...:|..|.|||:         ::|.
Worm   366 LSFQKFAEWSSRTRRIASSEAVVIANSSEKLT---LEGKHLKISVYLEAPFV---------MITS 418

  Fly   442 NSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMT 506
            |..||||.|||:::||.:|.|.:..:...|..||: .:....|.|:|.:|..|:|||.:..||::
Worm   419 NGSYEGYCIDLLHKIANILKFTYTIQKVRDNAYGS-KESNGKWSGMVGELQRGDADLAVASLTIS 482

  Fly   507 SSRRQAVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMA 571
            ..|.:.:|||.|:|.|||||||.||....:|.|.|:.|.|..|||...::|..:|:.::.:|:::
Worm   483 YGRSEVIDFTVPYMHLGISILFKKPRIRDSDWFKFMDPLSTQVWIMTFASYFVVSVAIWIIAKIS 547

  Fly   572 P-DDWENPHPCKEPEEVENIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMWWFFALMMLNS 635
            | :.:|......:.:.|:|.:|:.|:.|.::.|||.||.::.|:||||||:||:||||||::::|
Worm   548 PYEQFERDEDNGQYKPVDNQFSLRNSFWFTVCSLMQQGSELCPRAASTRLLTGIWWFFALILISS 612

  Fly   636 YTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPS 700
            |||||||.||..|....|.:|:|||||:|||||.:..||||.||.:|...||::||..| |:||.
Worm   613 YTANLAAVLTTRRMETPIENADDLAAQTKIKYGTLGRGSTMSFFNESKIETYERMWQLM-SSSPG 676

  Fly   701 VFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVERKCDLVQIGGWLDYKSYGIAMPFNSPYRKQI 765
            :|.:::.||:.||:...  ||:||||:.|||.|||.|:|:||||.:|.|.|||.:|..||||:.|
Worm   677 LFVQSSKEGIARVKSSD--YAYLMESSMLEYAVERDCELMQIGGLIDQKGYGIGLPKGSPYRELI 739

  Fly   766 SAAVLKLGELGQLAELKRKWWKEMHGGGNCE---KSDEDGGDTPELGLENVGGVFLVLGLGLLSA 827
            |.|:|:|.|..:|.|||.||||:.  ...||   :.|:|.|       |::||:|::|.:||:..
Worm   740 STAILRLQEKTELTELKEKWWKDK--SVVCEQPKRKDQDDG-------ESIGGIFIILVVGLVLT 795

  Fly   828 MVLGCTEFLWNVKSVAIEEKI 848
            .||...|.:...|....:.::
Worm   796 AVLVIFELITTRKPSPAQSQV 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	77/343 (22%)
		ANF_receptor	39..379	CDD:279440	74/322 (23%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	168/373 (45%)
		Lig_chan	548..812	CDD:278489	123/267 (46%)
glr-3	NP_492017.3	PBP1_iGluR_non_NMDA-like	21..385	CDD:380591	77/343 (22%)
glr-3	NP_492017.3	Periplasmic_Binding_Protein_Type_2	401..761	CDD:419667	168/372 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		otm14234
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.820