Protein Alignment clumsy and Grin3b

DIOPT Version :9

• Sequence 1: NP_001036373.1
• Gene: clumsy / 35394
• FlyBaseID: FBgn0026255
• Length: 1002
• Species: Drosophila melanogaster
• Sequence 2: XP_006513350.1
• Gene: Grin3b / 170483
• MGIID: 2150393
• Length: 1138
• Species: Mus musculus
• Alignment Length: 1003
• Identity: 212/1003 - (21%)
• Similarity: 367/1003 - (36%)
• Gaps: 232/1003 - (23%)

  Fly    52 LERNVELVPIVVYANTDDSFIMEKMVCNLIS-QGVIA-IFGPSTGSSSDIIASICDTLDIP---- 110
            |..|:.|..:.|.:.|.|...:.:.:|.::: .||:| |..|.......::..:....:.|
Mouse   146 LPHNLSLELVAVASPTRDPASLARGLCQVLAPPGVVASITFPEARPELRLLQFLAAATETPVLSV 210

  Fly   111 ---------------HIVYDWI-PNESIPDREHSTMTLNVHPDNLLLSQGLAEIVQSFAWRSFTV 159
                           |:..||. |.|:|.|                   .|..:|::.||....:
Mouse   211 LRREVRAPLGAPTPFHLQLDWASPLETILD-------------------VLVSLVRAHAWEDIAL 256

  Fly   160 VYETDKELQQLQDILQVGEPISNPT--------------TVKQLGPGDDH--------------- 195
            |            :.:|.:|....|              .:.||..|:|.
Mouse   257 V------------LCRVRDPSGLVTLWTSRASQAPKFVLDLSQLDSGNDSLRATLALLGTLEGGG 309

  Fly   196 RPFLKEIKLSTDNCLILHC---------APDNLLKILQQANELKMLGEYQSVFI------PLLDT 245
            .|....:.|   .|...|.         .|..||.....|..|...|....|.:      |.|:.
Mouse   310 TPVSAAVLL---GCSTAHAHEVLEAAPPGPQWLLGTPLPAEALPKTGLPPGVLVLGETGQPSLEA 371

  Fly   246 HSIDFGELSGVEANITTVRLMD------PSDFHVKNVVHDWEEREKR-----------EGRYFKV 293
            ...|..||  |...::::.||.      |:..:.:::.....|...|           :||
Mouse   372 AVHDMVEL--VARALSSMALMHPERALLPAAVNCEDLKTGGSESTARTLARFLSNTSFQGR---- 430

  Fly   294 DPNRVKSQMILLNDAVWLFSKGLTELGIFEELTAPDLECRRKKPW-----PFGKRIIEFIKARSE 353
                        ..|||:  .|.:::.:          .|..|.|     |.|......:.:..:
Mouse   431 ------------TGAVWV--AGSSQVHV----------SRHFKVWSLRRDPLGAPAWATVGSWQD 471

  Fly   354 ETSTGRIDF----------NENGQRSFFTLRFMELNSDGFLDLATWDPVNGLDVLNDDEESEKRV 408
                |::||          :.:|.::...||.:.|....|           :.....||:.:...
Mouse   472 ----GQLDFQPGAAALRVPSPSGTQARPKLRVVTLVEHPF-----------VFTRESDEDGQCPA 521

  Fly   409 GQKLSNKTFIVSSRLGAPFLTLREPQEGEILTGNSR--YEGYSIDLINEIAKMLNFKFEFRMSPD 471
            ||...:.....|:||.|.|..|   :.|.:.....|  | ||.|||:..:|:.|.|.||..:..|
Mouse   522 GQLCLDPGTNDSARLDALFTAL---ENGSVPRTLRRCCY-GYCIDLLERLAEDLAFDFELYIVGD 582

  Fly   472 GKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPPT 536
            ||||||.  ...|.|:|..|:.|.|.:.:...::.|:|.|.||||.||.:..:.|:.....| .:
Mouse   583 GKYGALR--DGRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRTRDT-AS 644

  Fly   537 DLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENPHP-CKEPEEVENIWSIMNTTWLS 600
            .:.:|:.|....:|:.:.:| |.::.|...|.     :|.:|:. .........::|..:...|.
Mouse   645 PIGAFMWPLHWSMWVGVFAA-LHLTALFLTLY-----EWRSPYGLTPRGRNRGTVFSYSSALNLC 703

  Fly   601 IGSLMGQGCDI-LPKAASTRLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAED--LAAQ 662
            ...|.|:.... .||..:.|.:..:|..|.|::|:||||||||.:...:....::...|  |...
Mouse   704 YAILFGRTVSSKTPKCPTGRFLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHP 768

  Fly   663 SK-IKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTKTNDEGVERVQKG-KNLYAFLME 725
            |: .::|.:...|...:.:    :::.:|...|...|    ..|...||..:... ..|.||:|:
Mouse   769 SQGFRFGTVWESSAEAYIK----ASFPEMHAHMRRHS----APTTPHGVAMLTSDPPKLNAFIMD 825

  Fly   726 STTLEY--NVERKCDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKE 788
            .:.|:|  :::..|.|:.:|.....:.|||.:|.|||....:|..:.:....|.:..|..||:|.
Mouse   826 KSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKM 890

  Fly   789 MHGGGNCEKSDEDGGDTPELGLENVGGVFLVLGLGLLSAMVLGCTEFLWNVKSVAIEEKISLKEA 853
            :    .|.|......:|.::|:.::.|:|::|.|||.||::....|.::        .::.|...
Mouse   891 V----PCGKRVFAVTETLQMGVYHLSGLFVLLCLGLGSALLTSLGEHVF--------YRLVLPRI 943

  Fly   854 FKSEALFAARIWITTKPVHTSSESGSSNSSSSSSSRSKHSF-------KSQGLSMKSLKSSGYQD 911
            .:...|   :.|:.|..|....:.|  .......|..||..       ..|..:.:.....|...
Mouse   944 RRGNKL---QYWLHTSQVRRQDKVG--RGGGHLRSLPKHLSVPLEDPPSPQHRATRGATGEGRAG 1003

  Fly   912 VEASVHSKLKKIGSMFSLKSQKTVTPPP 939
            |:.:..........:..|.|::.|.|||
Mouse  1004 VQVTTGRGGAGQSGVPGLASRQAVLPPP 1031

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	73/441 (17%)
		ANF_receptor	39..379	CDD:279440	71/424 (17%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	103/382 (27%)
		Lig_chan	548..812	CDD:278489	63/271 (23%)
Grin3b	XP_006513350.1	PBP1_iGluR_NMDA_NR3	141..481	CDD:380600	68/402 (17%)
		PBP2_iGluR_NMDA_Nr3	494..888	CDD:270438	110/425 (26%)
		Lig_chan	656..922	CDD:365843	67/283 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846269
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830