DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and gria2a

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	XP_005170953.1	Gene:	gria2a / 170450	ZFINID:	ZDB-GENE-020125-3	Length:	893	Species:	Danio rerio

Alignment Length:	930	Identity:	317/930 - (34%)
Similarity:	484/930 - (52%)	Gaps:	77/930 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LFLTHFLLIALPVLADIDRSQFMVGSIFTSDKDESEIAFRTAVDRANILERNVELVPIVVYANTD 68
            :.|:..||.||..||........:|.:|....|:...|||..:.:....|  ..|.|.:......
Zfish     1 MILSGLLLPALWGLALGGSPSVQIGGLFPRGADQEYSAFRIGMVQFGTAE--FRLTPHIDNLEVA 63

  Fly    69 DSFIMEKMVCNLISQGVIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESIPDREHSTMTLN 133
            :||.:....|:..|:||.||||.....|.:.|.|.|:||.:..|      ..|.|....:...|.
Zfish    64 NSFAITNCFCSQFSRGVYAIFGFYDKKSVNTITSFCETLHVSFI------TPSFPADGLNQFVLQ 122

  Fly   134 VHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEPISNPTTVKQLGPGDD---- 194
            :.||   :...|..:|:.:.|..|..:|::|:.|..||.:|..........|...:|...|
Zfish   123 MRPD---IKGPLISLVEYYKWEKFAYLYDSDRGLSTLQAVLDTAAERKWQVTAINVGNLKDEWKD 184

  Fly   195 --HRPFLKEIKLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFGELSGVE 257
              :|...::::...:..:||.|..|.:..|::|   :..:|.:...:..::.......|:||.::
Zfish   185 EAYRSLFQDLENKNERRVILDCEQDKVKDIMEQ---VITIGRHVKGYHYIIANFGFVDGDLSKIQ 246

  Fly   258 ---ANITTVRLMDPSDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDAVWLFSKGLTEL 319
               ||::..:::|..|..|......||..|::|  |...| :|::....|..|||.:    :||.
Zfish   247 YGGANVSGFQIVDFDDPLVAKFDQRWEALEEKE--YPGAD-SRIRYTSALTYDAVQV----MTEA 304

  Fly   320 GIFEELTAPDLECRRKK---------PWPFGKRIIEFIKARSEETSTGRIDFNENGQRSFFTLRF 375
            ..|......|:..|...         ||..|..|...:|....:..||.|.|::.|:|..:|:..
Zfish   305 FRFLHKQRIDISRRGNNGDCLANPAVPWAQGVEIERALKQVRVDGLTGNIQFDQYGRRVNYTVNV 369

  Fly   376 MELNSDGFLDLATWDPVNGLDVLNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLREPQEGEILT 440
            |||.:.|.:.:..|:.::.:.|...|......:|  :.|||.||::.|.||::.|:  :..|:.|
Zfish   370 MELKNSGPVKIGYWNEMDKMAVTKSDLFPNDTMG--MENKTVIVTTILEAPYVMLK--KNAELFT 430

  Fly   441 GNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTM 505
            .|.|||||.:||..||||...||::.|:..||||||.:..|:.|:|:|.:|:.|.||:.:..||:
Zfish   431 DNERYEGYCVDLAAEIAKHCGFKYQLRIVADGKYGARDAETKIWNGMVGELVYGKADIAVAPLTI 495

  Fly   506 TSSRRQAVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARM 570
            |..|.:.:||:.|||:|||||:..||......:||||.|.:.::|:.:..||:.:|::||.::|.
Zfish   496 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRF 560

  Fly   571 APDDWENPHPCKE-------PEEVENIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMWWFF 628
            :|.:|..    :|       |.|..|.:.|.|:.|.|:|:.|.|||||.|::.|.|:|.|:||||
Zfish   561 SPYEWHT----EEFEDGQLGPSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFF 621

  Fly   629 ALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQKMWTA 693
            .|::::|||||||||||..|..:.|.||||||.|::|.||.:..|||..|||.|..:.:.|||..
Zfish   622 TLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDAGSTKEFFRRSKIALFDKMWQY 686

  Fly   694 MESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVERK-CDLVQIGGWLDYKSYGIAMPF 757
            |:||.||||.|...|||.||:|.|..||:|:|||..||..:|| ||.:::||.||.|.||||.|.
Zfish   687 MKSAEPSVFVKNTVEGVLRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPK 751

  Fly   758 NSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPE----LGLENVGGVFL 818
            .|..|..::.|||||.|.|.|.:||.|||   :..|.|   ...||::.|    |.|.||.|||.
Zfish   752 GSALRNAVNLAVLKLNEQGLLDKLKNKWW---YDKGEC---GSGGGESKEKTSALSLSNVAGVFY 810

  Fly   819 VL--GLGLLSAMVLGCTEFLWNVKSVAIEEKISLKEAFKSEALFAARIWITTKPVHTSSESGSSN 881
            :|  ||||  ||::...||.:..::.|...|::..:|.:|:    ||:.||    .::.|:|...
Zfish   811 ILVGGLGL--AMLVALVEFCYKSRAEAKRMKMTFTDAMRSK----ARLSIT----GSTGENGRVL 865

  Fly   882 SSSSSSSRSKHSFKSQGLSM 901
            :...|.:.....:...|::|
Zfish   866 TPDFSKAVHAVPYLRPGMAM 885

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	93/387 (24%)
		ANF_receptor	39..379	CDD:279440	87/357 (24%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	179/380 (47%)
		Lig_chan	548..812	CDD:278489	126/275 (46%)
gria2a	XP_005170953.1	Periplasmic_Binding_Protein_Type_1	23..391	CDD:299141	93/388 (24%)
		ANF_receptor	51..373	CDD:279440	83/340 (24%)
		PBP2_iGluR_AMPA	406..783	CDD:270433	180/385 (47%)
		Lig_chan	538..816	CDD:278489	132/287 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591078
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.750