Protein Alignment clumsy and Grin2d

DIOPT Version :9

• Sequence 1: NP_001036373.1
• Gene: clumsy / 35394
• FlyBaseID: FBgn0026255
• Length: 1002
• Species: Drosophila melanogaster
• Sequence 2: XP_036008580.1
• Gene: Grin2d / 14814
• MGIID: 95823
• Length: 1345
• Species: Mus musculus
• Alignment Length: 852
• Identity: 187/852 - (21%)
• Similarity: 318/852 - (37%)
• Gaps: 249/852 - (29%)

  Fly   118 PNESIPDREHSTMTLNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEPISN 182
            |.|...::|..:..|.:........|.:.|:::.:.|.||..|
Mouse   150 PKEQGHEKEKGSTFLQLGSSTEQQLQVIFEVLEEYDWTSFVAV---------------------- 192

  Fly   183 PTTVKQLGPGDDHRPFLKEIKLSTDNCLI--------------------------------LHCA 215
             ||   ..||  ||.||..|::.||..|:                                |.||
Mouse   193 -TT---RAPG--HRAFLSYIEVLTDGSLVGWEHRGALTLDPGAGEAVLGAQLRSVSAQIRLLFCA 251

  Fly   216 PDNLLKILQQANELKMLGEYQSVFI----------------PLLDTHSIDFGELSG--------- 255
            .:....:.:.|.|..:.|.....|:                |||         |.|
Mouse   252 REEAEPVFRAAEEAGLTGPGYVWFMVGPQLAGGGGSGVPGEPLL---------LPGGAPLPAGLF 307

  Fly   256 --------------VEANITTVR------LMD----PS---DFHVKNVVH------------DWE 281
                          |.|.:..|.      |.|    |.   |...:|..|            .|:
Mouse   308 AVRSAGWRDDLARRVAAGVAVVARGAQALLRDYGFLPELGHDCRAQNRTHRGESLHRYFMNITWD 372

  Fly   282 ERE---KREGRYFKVDPNRVKSQMILLNDAVWLFSKGLTELGIFEELTAPDLECRRKKPWPFGKR 343
            .|:   ..:|  |.|:|:.|  .:.|..|..|      ..:|.:|:.|.       :..:|...|
Mouse   373 NRDYSFNEDG--FLVNPSLV--VISLTRDRTW------EVVGSWEQQTL-------RLKYPLWSR 420

  Fly   344 IIEFIKARSEETSTGRIDFNENGQRSFFTLRFMELNSDGFLDLATWDPVNGLDVLNDDEESEKRV 408
            ...|::.         :|..::       |....|....|:.:...||::| ..:.|......::
Mouse   421 YGRFLQP---------VDDTQH-------LTVATLEERPFVIVEPADPISG-TCIRDSVPCRSQL 468

  Fly   409 GQKLSNKTFIVSSRLGAPFLTLREPQEGEILTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGK 473
                 |:|    ..|.||    |.|............:|:.||::..:|..:.|.::..:..:||
Mouse   469 -----NRT----HSLVAP----RSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTNGK 520

  Fly   474 YGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSK-------- 530
            :|  .|:...|:|::.::....||:.|..||:...|.:.|||:.||:..|||::.::
Mouse   521 HG--KKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPS 583

  Fly   531 ---------PPTPPTDLFSFLSPFSLDVWIYMGSAYL-FISLLLFALARMAPDDWENPHPC-KEP 584
                     ||..|       .|:|..||:.|....| .:::.:|....::|..:...... |.|
Mouse   584 AFLAFAWLMPPMSP-------EPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRP 641

  Fly   585 EEVENIWSIMNTTWLSIGSLMGQGCDI-LPKAASTRLVTGMWWFFALMMLNSYTANLAAFLTNSR 648
            .  .:.::|..:.||....:......: .|:..:::::..:|.|||::.|.|||||||||:....
Mouse   642 G--GSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEE 704

  Fly   649 QANSINSAEDLAAQ------SKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAM-ESASPSVFTKTN 706
            ..::::...|...|      ..:|:|.:..|||....|    |.|..|.:.| ....|.|
Mouse   705 YVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIR----SNYPDMHSYMVRYNQPRV----- 760

  Fly   707 DEGVERVQKGKNLYAFLMESTTLEYNVERK---CDLVQIGGWLDYKS--YGIAMPFNSPYRKQIS 766
            :|.:.:::.|| |.||:.::..|.| :.||   |.||.||....:.:  ||||:...|.:::.|.
Mouse   761 EEALTQLKAGK-LDAFIYDAAVLNY-MARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPID 823

  Fly   767 AAVLK-LGELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVGGVFLVLGLGLLSAMVL 830
            .|:|: ||: .::..|:|.|.     .|.|. :|:....:.:|.::|:.|||.:    ||.||.|
Mouse   824 LALLQFLGD-DEIEMLERLWL-----SGICH-NDKIEVMSSKLDIDNMAGVFYM----LLVAMGL 877

  Fly   831 GCTEFLW 837
            ....|.|
Mouse   878 SLLVFAW 884

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	66/376 (18%)
		ANF_receptor	39..379	CDD:279440	61/359 (17%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	105/405 (26%)
		Lig_chan	548..812	CDD:278489	72/279 (26%)
Grin2d	XP_036008580.1	Periplasmic_Binding_Protein_type1	<156..415	CDD:415822	54/312 (17%)
		PBP2_iGluR_NMDA_Nr2	432..849	CDD:270436	114/466 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846257
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.830