Protein Alignment clumsy and Grin2c

DIOPT Version :10

• Sequence 1: NP_001036373.1
• Gene: clumsy / 35394
• FlyBaseID: FBgn0026255
• Length: 1002
• Species: Drosophila melanogaster
• Sequence 2: XP_017169765.1
• Gene: Grin2c / 14813
• MGIID: 95822
• Length: 1307
• Species: Mus musculus
• Alignment Length: 1136
• Identity: 231/1136 - (20%)
• Similarity: 419/1136 - (36%)
• Gaps: 301/1136 - (26%)

  Fly    43 RTAVDRANILERNVELVPIVV-YANTDDSFIMEKMVCNLI------------------------- 81
            ||.:...|.|:..:|:.|:.: ..||:.|.|:.: :|.|:
Mouse   109 RTRLTPQNFLDLPLEIQPLTIGVNNTNPSSILTQ-ICGLLGAARVHGIVFEDNVDTEAVAQLLDF 172

  Fly    82 --SQGVIAIFGPSTGSS------------SDIIASICDTLDIPHIV---YDWIPNESIPDREHST 129
              ||..:.|...|.||:            ..:..|:...|.:...|   |||         ....
Mouse   173 VSSQTHVPILSISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDW---------SAFA 228

  Fly   130 MTLNVHPDNLLLSQGLAEIVQS--FAWRSFTVVYETDKELQQLQDILQVGEPISNPTTVKQLGPG 192
            :..::||.:.|..:|:..:..:  .:||              |.|:|.:           :||||
Mouse   229 VITSLHPGHALFLEGVRAVADASYLSWR--------------LLDVLTL-----------ELGPG 268

  Fly   193 DDHRPFLKEIKLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFGELSGVE 257
            .......:.::......|:.:|:.:....:..:|.:..::|......:|.|...|.|
Mouse   269 GPRARTQRLLRQVDAPVLVAYCSREEAEVLFAEAAQAGLVGPGHVWLVPNLALGSTD-------- 325

  Fly   258 ANITTVRLMDPSDFHV---KNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDAVWLFSKGL--- 316
                    ..|:.|.|   ..|...|....:::.|                 |.|.:.:.|.
Mouse   326 --------APPAAFPVGLISVVTESWRLSLRQKVR-----------------DGVAILALGAHSY 365

  Fly   317 -TELGIFEELTAPDLECRRKKPWPFGKRIIEFIKARSEETSTGR-IDFNENGQRSFFTLRFMELN 379
             .:.|   .|.||..:| |..|.|.......|.:.....|..|| ..|:..|.....|:..:.||
Mouse   366 RRQYG---TLPAPAGDC-RSHPGPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVQPTMVVIALN 426

  Fly   380 SDGFLDL-ATWD--------PV-----NGLDVLNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTL 430
            .....:: ..||        ||     ..|..:.|             ::...|::....||:.:
Mouse   427 RHRLWEMVGRWDHGVLYMKYPVWPRYSTSLQPVVD-------------SRHLTVATLEERPFVIV 478

  Fly   431 REPQEGEILTG-------------NSRY-------------EGYSIDLINEIAKMLNFKFEFRMS 469
            ..|..|   ||             |..:             :|:.||::.::||::.|.::..:.
Mouse   479 ESPDPG---TGGCVPNTVPCRRQSNHTFSSGDITPYTKLCCKGFCIDILKKLAKVVKFSYDLYLV 540

  Fly   470 PDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILF--SKPP 532
            .:||:|  .:|...|:|::.::....||:.|..||:...|.:.:||:.||:..|||::.  |...
Mouse   541 TNGKHG--KRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIIDFSVPFVETGISVMVARSNGT 603

  Fly   533 TPPTDLFSFLSPFSLDVWIYMGSAYL-FISLLLFALARMAPDDWENPHPCKEPEEVENIWSIMNT 596
            ..|:   :||.|:|..||:.|....| .:::.:|.....:|..: |.:..|..:.....::|..:
Mouse   604 VSPS---AFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSY-NQNLTKGKKSGGPSFTIGKS 664

  Fly   597 TWLSIGSLMGQGCDI-LPKAASTRLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLA 660
            .||....:......| .|:..:::::..:|.|||::.|.|||||||||:...:..::::...|..
Mouse   665 VWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKK 729

  Fly   661 AQ------SKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTKTNDEGVE----RVQK 715
            .|      ...::|.:..|||....|    |.|:.|.|.|        .|.|...||    .::.
Mouse   730 FQRPQDQYPPFRFGTVPNGSTERNIR----SNYRDMHTHM--------VKFNQRSVEDALTSLKM 782

  Fly   716 G-----KNLYAFLMESTTLEY--NVERKCDLVQIGGWLDYKS--YGIAMPFNSPYRKQISAAVLK 771
            |     :.|.||:.::..|.|  ..:..|.||.||....:.:  |||||..:|.:::.|..|:|:
Mouse   783 GARHVSRKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQ 847

  Fly   772 -LGELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVGGVFLVLGLGLLSAMVLGCTEF 835
             ||: |:..:|:..|.     .|.|. ::::...:.:|.::|:.|||.:|.:.:..|:::...|.
Mouse   848 FLGD-GETQKLETVWL-----SGICH-NEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEH 905

  Fly   836 L--WNVK-SVAIEEKISLKEAFKSEALFAARIWITTKPVHTSSESGSSNSSSSSSSRSKHSFKSQ 897
            |  |.:: ||....::....|| |..:::....:.:.|......|....:.|           :|
Mouse   906 LVYWKLRHSVPSSSQLDFLLAF-SRGIYSCFNGVQSLPSPARPPSPDLTAGS-----------AQ 958

  Fly   898 GLSMKSLKSS----GYQDVEASVHSKLKKIGSMF--------SLKSQKTVTP-----PPEIGWKL 945
            ...:|.|:::    ...||..|:....:.|.:..        :....::.||     |...||:.
Mouse   959 ANVLKMLQAARDMVSTADVSGSLDRATRTIENWGNNRRAPAPTTSGPRSCTPGPPGQPSPSGWRP 1023

  Fly   946 DKSTQIDVV----------------PTSDVDQELIPEV-EPHLPHRHHHHHHH------------ 981
            ....:..:.                |..||.:...... :...|.|..|...|
Mouse  1024 PGGGRTPLARRAPQPPARPATCAGSPQPDVSRASCRHAWDARWPVRVGHQGSHLSASERRALPER 1088

  Fly   982 --RHHHHHHQPDQEHDRN--------PSPPE 1002
              .|.|.|:......:|:        |.|||
Mouse  1089 SLLHAHCHYSSFPRAERSGRPFLPLFPEPPE 1119

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	27..397	CDD:380605	76/420 (18%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	107/422 (25%)
Grin2c	XP_017169765.1	PBP1_iGluR_NMDA_NR2	90..446	CDD:380601	73/408 (18%)
		PBP2_iGluR_NMDA_Nr2	462..868	CDD:270436	109/433 (25%)
		NMDAR2_C	905..>980	CDD:463148	15/86 (17%)