Protein Alignment clumsy and Grin2b

DIOPT Version :10

• Sequence 1: NP_001036373.1
• Gene: clumsy / 35394
• FlyBaseID: FBgn0026255
• Length: 1002
• Species: Drosophila melanogaster
• Sequence 2: NP_032197.3
• Gene: Grin2b / 14812
• MGIID: 95821
• Length: 1482
• Species: Mus musculus
• Alignment Length: 1116
• Identity: 249/1116 - (22%)
• Similarity: 442/1116 - (39%)
• Gaps: 279/1116 - (25%)

  Fly    10 LLIALPVLADIDRSQ----------FMVGSIFTSDKDESEIAFRTAVDRANILERNVELVP---I 61
            :|..|.|.....|||          .:||   |||    |:|.:.|.::.:.  .::.:||   :
Mouse    15 VLAVLAVSGSKARSQKSAPSIGIAVILVG---TSD----EVAIKDAHEKDDF--HHLSVVPRVEL 70

  Fly    62 VVYANTDDSFIMEKMVCNLIS----QGVIAIFGPSTGSSSDIIASICDTLD----IPHIVYDWIP 118
            |....||...|:.: :|:|:|    |||  :|...|  ..:.||.|.|.:.    .|.:......
Mouse    71 VAMNETDPKSIITR-ICDLMSDRKIQGV--VFADDT--DQEAIAQILDFISAQTLTPILGIHGGS 130

  Fly   119 NESIPDREHSTMTLNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDIL-QVGEPISN 182
            :..:.|::.|:|.....|.....:..:..|::.:.|..|::|   .......||.: ::...|.|
Mouse   131 SMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIV---TTYFPGYQDFVNKIRSTIEN 192

  Fly   183 --------PTTVKQLGPGDDHRPFLKEIKLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVF 239
                    ...:..:...|.......::|......::|:|..:....|.:.||.:.:.|...:..
Mouse   193 SFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWI 257

  Fly   240 IPLLDTHSIDFGELSGVEANITTVRLMDPSDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMIL 304
            :|.|            |..:..||    ||:|....:...::|.:...       |.||:..:.:
Mouse   258 VPSL------------VAGDTDTV----PSEFPTGLISVSYDEWDYGL-------PARVRDGIAI 299

  Fly   305 LNDAVWLFSKGLTELGIFEELTAPDLECRRKKPWPFGKRIIE---FIKARSEETSTGR-IDFNEN 365
            :..|.   |..|:|.....|   |...|.....    |||.:   ..:.....|..|| :.|:|:
Mouse   300 ITTAA---SDMLSEHSFIPE---PKSSCYNTHE----KRIYQSNMLNRYLINVTFEGRNLSFSED 354

  Fly   366 GQRSFFTLRFMELNSDGFLDLATWDPVNGLDVLNDDE-------------ESEKRVGQKLSNKTF 417
            |.:....|..:.||.:     ..|:.|.   ...|..             |:|::....||
Mouse   355 GYQMHPKLVIILLNKE-----RKWERVG---KWKDKSLQMKYYVWPRMCPETEEQEDDHLS---- 407

  Fly   418 IVSSRLGAPFLTLRE-------------PQEGEILTGNSRYE----------GYSIDLINEIAKM 459
            ||:.. .|||:.:..             |.:..|::.|...|          |:.||::.:|:|.
Mouse   408 IVTLE-EAPFVIVESVDPLSGTCMRNTVPCQKRIISENKTDEEPGYIKKCCKGFCIDILKKISKS 471

  Fly   460 LNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGI 524
            :.|.::..:..:||:|  .|:..||:|::.:::...|.:.:..||:...|.:.|||:.||:..||
Mouse   472 VKFTYDLYLVTNGKHG--KKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGI 534

  Fly   525 SILFSKP--PTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENP---HPC--- 581
            |::.|:.  ...|:   :||.|||.|||:.|     |:.||:.:...:...::.:|   :.|
Mouse   535 SVMVSRSNGTVSPS---AFLEPFSADVWVMM-----FVMLLIVSAVAVFVFEYFSPVGYNRCLAD 591

  Fly   582 -KEPEEVENIWSIMNTTWLSIGSLMGQGCDIL-PKAASTRLVTGMWWFFALMMLNSYTANLAAFL 644
             :||....  ::|....||..|.:......:. ||..:::::..:|.|||::.|.|||||||||:
Mouse   592 GREPGGPS--FTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFM 654

  Fly   645 TNSRQANSINSAEDLAAQ------SKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFT 703
            ......:.::...|...|      ...::|.:..|||....|::    |.:|...|        .
Mouse   655 IQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNN----YAEMHAYM--------G 707

  Fly   704 KTNDEGVE----RVQKGKNLYAFLMESTTLEYNVERK--CDLVQIGGWLDYKS--YGIAMPFNSP 760
            |.|..||:    .::.|| |.||:.::..|.|...|.  |.||.||....:.|  ||||:..:|.
Mouse   708 KFNQRGVDDALLSLKTGK-LDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSG 771

  Fly   761 YRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVGGVFLVLGLGL- 824
            :::|:..|:|:|...|::.||:..|..     |.|. ::::...:.:|.::|:.|||.:||..:
Mouse   772 WKRQVDLAILQLFGDGEMEELEALWLT-----GICH-NEKNEVMSSQLDIDNMAGVFYMLGAAMA 830

  Fly   825 LSAMVLGCTE-FLWN--------------------------VKSVAIEEKISLKEAFKSEALFAA 862
            ||.:...|.. |.|.                          :..|||||:.|:
Mouse   831 LSLITFICEHLFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSV------------ 883

  Fly   863 RIWITTKPVHTSSESGSSNSSSSSSSRSKHSFKSQGLSMKSLKSSGYQDVEASVHSKLKKIGSMF 927
                      .:|.:.:.|::.|:..|...:.|    :|.:|  ||......|....:::..|::
Mouse   884 ----------MNSPTATMNNTHSNILRLLRTAK----NMANL--SGVNGSPQSALDFIRRESSVY 932

  Fly   928 SLKSQKTV----------TPPPEIGWKLDKSTQIDVVPTSDVDQELIPEVEPHL---------PH 973
            .:...:..          .||.|                .::..:.|.|||...         .:
Mouse   933 DISEHRRSFTHSDCKSYNNPPCE----------------ENLFSDYISEVERTFGNLQLKDSNVY 981

  Fly   974 RHHHHHHHRHH 984
            :.|:|||||.|
Mouse   982 QDHYHHHHRPH 992

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	27..397	CDD:380605	80/393 (20%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	113/419 (27%)
Grin2b	NP_032197.3	PBP1_iGluR_NMDA_NR2	33..388	CDD:380601	81/412 (20%)
		PBP2_iGluR_NMDA_Nr2	403..803	CDD:270436	117/435 (27%)
		NMDAR2_C	840..1482	CDD:463148	33/197 (17%)