DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment clumsy and Grin2a

DIOPT Version :9

Sequence 1:NP_001036373.1 Gene:clumsy / 35394 FlyBaseID:FBgn0026255 Length:1002 Species:Drosophila melanogaster
Sequence 2:NP_032196.2 Gene:Grin2a / 14811 MGIID:95820 Length:1464 Species:Mus musculus


Alignment Length:1177 Identity:249/1177 - (21%)
Similarity:427/1177 - (36%) Gaps:363/1177 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 LTHFLLIALPVL-----------ADIDRSQFMVGSIFTSDKDESEIAFRT--AVDRANILERNVE 57
            |.::.|:.||.|           |:.......:..:.....|.:|...|.  ..::|..|..:|.
Mouse     4 LGYWTLLVLPALLVWHGPAQNAAAEKGTPALNIAVLLGHSHDVTERELRNLWGPEQATGLPLDVN 68

  Fly    58 LVPIVVYANTDDSFIMEKMVCNLISQGVI--AIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNE 120
            :|.:::......|.|..  ||:|:|...|  .:||..|  ..:.:|.          :.|:|.::
Mouse    69 VVALLMNRTDPKSLITH--VCDLMSGARIHGLVFGDDT--DQEAVAQ----------MLDFISSQ 119

  Fly   121 S-IPDREHSTMTLNVH-----------PDNLLLSQG---------LAEIVQSFAWRSFTVVYETD 164
            : ||       .|.:|           |.:.....|         :.:|:|.:.|..|::|    
Mouse   120 TFIP-------ILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLV---- 173

  Fly   165 KELQQLQDILQVGEPISNPTTVKQLGPGDDHRPFLKEIKLSTDN--------------------- 208
                               ||:   .||  :|.|:..||.:.||                     
Mouse   174 -------------------TTI---FPG--YRDFISFIKTTVDNSFVGWDMQNVITLDTSFEDAK 214

  Fly   209 -----------CLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFGELSGVEANITT 262
                       .::|:|:.|..:.||.:|..|.:.|......:|.|            |..|...
Mouse   215 TQVQLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSL------------VSGNTEL 267

  Fly   263 VRLMDPSDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDAVWLFSKGLTELGIFEELTA 327
            :....||.. :.....||:         :.::. ||:..:.:|..|.   |..|.:.....|..|
Mouse   268 IPKEFPSGL-ISVSYDDWD---------YSLEA-RVRDGLGILTTAA---SSMLEKFSYIPEAKA 318

  Fly   328 PDLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNENGQRSFFTLRFMELNSDGFLDLATWDPV 392
               .|       :|:                    .|..:....||....:|       .|||  
Mouse   319 ---SC-------YGQ--------------------TEKPETPLHTLHQFMVN-------VTWD-- 344

  Fly   393 NGLD-----------------VLNDDEESEKRVGQKLSNKTFIVSSRL----------------- 423
             |.|                 |||.|.|.|| || |..|:|..:...:                 
Mouse   345 -GKDLSFTEEGYQVHPRLVVIVLNKDREWEK-VG-KWENQTLSLRHAVWPRYKSFSDCEPDDNHL 406

  Fly   424 ------GAPFLTLRE-------------PQEGEILTGNSRYE---------GYSIDLINEIAKML 460
                  .|||:.:.:             |....:...||..|         |:.||::.::::.:
Mouse   407 SIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTV 471

  Fly   461 NFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGIS 525
            .|.::..:..:||:|  .||...|:|::.:::...|.:.:..||:...|.:.|||:.||:..|||
Mouse   472 KFTYDLYLVTNGKHG--KKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGIS 534

  Fly   526 ILFSKP--PTPPTDLFSFLSPFSLDVWIYMGSAYLFIS-LLLFALARMAPDDWEN-------PHP 580
            ::.|:.  ...|:   :||.|||..||:.|....|.:| :.:|.....:|..:..       || 
Mouse   535 VMVSRSNGTVSPS---AFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPH- 595

  Fly   581 CKEPEEVENIWSIMNTTWLSIGSLMGQGCDIL-PKAASTRLVTGMWWFFALMMLNSYTANLAAFL 644
              .|.     ::|....||..|.:......:. ||..:::::..:|.|||::.|.|||||||||:
Mouse   596 --GPS-----FTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFM 653

  Fly   645 TNSRQANSINSAEDLAAQ------SKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFT 703
            ......:.:....|...|      ...::|.:..|||....|::....:|.|            |
Mouse   654 IQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYM------------T 706

  Fly   704 KTNDEGVE----RVQKGKNLYAFLMESTTLEYNVERK--CDLVQIGGWLDYKS--YGIAMPFNSP 760
            |.|..|||    .::.|| |.||:.::..|.|...|.  |.||.||....:.:  ||||:...||
Mouse   707 KFNQRGVEDALVSLKTGK-LDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSP 770

  Fly   761 YRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVGGVFLVLGLGLL 825
            :::||..|:|:....|::.||:..|..     |.|. ::::...:.:|.::|:.|||.:|.    
Mouse   771 WKRQIDLALLQFVGDGEMEELETLWLT-----GICH-NEKNEVMSSQLDIDNMAGVFYMLA---- 825

  Fly   826 SAMVLGCTEFLWNVKSVAIEEKISLKEAF--------KSEALFAAR--IWITTKPVHTSSESGSS 880
            :||.|....|:|       |.....|..|        :...||:..  |:.....||...:..|.
Mouse   826 AAMALSLITFIW-------EHLFYWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKKKSP 883

  Fly   881 NSSSSSSSRSKHSFKSQGLSMKSLKSSGYQDVEASVHSKLKKIGSMFSLKSQKTVTPPPEIGWKL 945
            :.:.:.         ||...:|.|:|:             |.|.:|.::.|.:..:|.....:..
Mouse   884 DFNLTG---------SQSNMLKLLRSA-------------KNISNMSNMNSSRMDSPKRAADFIQ 926

  Fly   946 DKSTQIDVVPT------SD---------VDQELIPEVEPHLPHRHHHHHHHRHHHHHHQPDQEHD 995
            ..|..:|:|..      ||         :..|.:.|::..:.:||.....:......| |...::
Mouse   927 RGSLIVDMVSDKGNLIYSDNRSFQGKDSIFGENMNELQTFVANRHKDSLSNYVFQGQH-PLTLNE 990

  Fly   996 RNPSPPE 1002
            .||:..|
Mouse   991 SNPNTVE 997

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
clumsyNP_001036373.1 PBP1_iGluR_Kainate 26..396 CDD:107377 75/426 (18%)
ANF_receptor 39..379 CDD:279440 69/396 (17%)
PBP2_iGluR_Kainate 414..787 CDD:270432 111/442 (25%)
Lig_chan 548..812 CDD:278489 75/286 (26%)
Grin2aNP_032196.2 PBP1_iGluR_NMDA_NR2 32..392 CDD:107373 88/476 (18%)
PBP2_iGluR_NMDA_Nr2 403..802 CDD:270436 111/430 (26%)
HisJ <458..>541 CDD:223904 24/84 (29%)
Lig_chan 556..828 CDD:278489 80/302 (26%)
NMDAR2_C 839..1464 CDD:287527 32/182 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167846237
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.840

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