Protein Alignment clumsy and Grin2a

DIOPT Version :10

• Sequence 1: NP_001036373.1
• Gene: clumsy / 35394
• FlyBaseID: FBgn0026255
• Length: 1002
• Species: Drosophila melanogaster
• Sequence 2: NP_032196.2
• Gene: Grin2a / 14811
• MGIID: 95820
• Length: 1464
• Species: Mus musculus
• Alignment Length: 1177
• Identity: 249/1177 - (21%)
• Similarity: 427/1177 - (36%)
• Gaps: 363/1177 - (30%)

  Fly     6 LTHFLLIALPVL-----------ADIDRSQFMVGSIFTSDKDESEIAFRT--AVDRANILERNVE 57
            |.::.|:.||.|           |:.......:..:.....|.:|...|.  ..::|..|..:|.
Mouse     4 LGYWTLLVLPALLVWHGPAQNAAAEKGTPALNIAVLLGHSHDVTERELRNLWGPEQATGLPLDVN 68

  Fly    58 LVPIVVYANTDDSFIMEKMVCNLISQGVI--AIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNE 120
            :|.:::......|.|..  ||:|:|...|  .:||..|  ..:.:|.          :.|:|.::
Mouse    69 VVALLMNRTDPKSLITH--VCDLMSGARIHGLVFGDDT--DQEAVAQ----------MLDFISSQ 119

  Fly   121 S-IPDREHSTMTLNVH-----------PDNLLLSQG---------LAEIVQSFAWRSFTVVYETD 164
            : ||       .|.:|           |.:.....|         :.:|:|.:.|..|::|
Mouse   120 TFIP-------ILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLV---- 173

  Fly   165 KELQQLQDILQVGEPISNPTTVKQLGPGDDHRPFLKEIKLSTDN--------------------- 208
                               ||:   .||  :|.|:..||.:.||
Mouse   174 -------------------TTI---FPG--YRDFISFIKTTVDNSFVGWDMQNVITLDTSFEDAK 214

  Fly   209 -----------CLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFGELSGVEANITT 262
                       .::|:|:.|..:.||.:|..|.:.|......:|.|            |..|...
Mouse   215 TQVQLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSL------------VSGNTEL 267

  Fly   263 VRLMDPSDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDAVWLFSKGLTELGIFEELTA 327
            :....||.. :.....||:         :.::. ||:..:.:|..|.   |..|.:.....|..|
Mouse   268 IPKEFPSGL-ISVSYDDWD---------YSLEA-RVRDGLGILTTAA---SSMLEKFSYIPEAKA 318

  Fly   328 PDLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNENGQRSFFTLRFMELNSDGFLDLATWDPV 392
               .|       :|:                    .|..:....||....:|       .|||
Mouse   319 ---SC-------YGQ--------------------TEKPETPLHTLHQFMVN-------VTWD-- 344

  Fly   393 NGLD-----------------VLNDDEESEKRVGQKLSNKTFIVSSRL----------------- 423
             |.|                 |||.|.|.|| || |..|:|..:...:
Mouse   345 -GKDLSFTEEGYQVHPRLVVIVLNKDREWEK-VG-KWENQTLSLRHAVWPRYKSFSDCEPDDNHL 406

  Fly   424 ------GAPFLTLRE-------------PQEGEILTGNSRYE---------GYSIDLINEIAKML 460
                  .|||:.:.:             |....:...||..|         |:.||::.::::.:
Mouse   407 SIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTV 471

  Fly   461 NFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGIS 525
            .|.::..:..:||:|  .||...|:|::.:::...|.:.:..||:...|.:.|||:.||:..|||
Mouse   472 KFTYDLYLVTNGKHG--KKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGIS 534

  Fly   526 ILFSKP--PTPPTDLFSFLSPFSLDVWIYMGSAYLFIS-LLLFALARMAPDDWEN-------PHP 580
            ::.|:.  ...|:   :||.|||..||:.|....|.:| :.:|.....:|..:..       ||
Mouse   535 VMVSRSNGTVSPS---AFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPH- 595

  Fly   581 CKEPEEVENIWSIMNTTWLSIGSLMGQGCDIL-PKAASTRLVTGMWWFFALMMLNSYTANLAAFL 644
              .|.     ::|....||..|.:......:. ||..:::::..:|.|||::.|.|||||||||:
Mouse   596 --GPS-----FTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFM 653

  Fly   645 TNSRQANSINSAEDLAAQ------SKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFT 703
            ......:.:....|...|      ...::|.:..|||....|::....:|.|            |
Mouse   654 IQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYM------------T 706

  Fly   704 KTNDEGVE----RVQKGKNLYAFLMESTTLEYNVERK--CDLVQIGGWLDYKS--YGIAMPFNSP 760
            |.|..|||    .::.|| |.||:.::..|.|...|.  |.||.||....:.:  ||||:...||
Mouse   707 KFNQRGVEDALVSLKTGK-LDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSP 770

  Fly   761 YRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVGGVFLVLGLGLL 825
            :::||..|:|:....|::.||:..|..     |.|. ::::...:.:|.::|:.|||.:|.
Mouse   771 WKRQIDLALLQFVGDGEMEELETLWLT-----GICH-NEKNEVMSSQLDIDNMAGVFYMLA---- 825

  Fly   826 SAMVLGCTEFLWNVKSVAIEEKISLKEAF--------KSEALFAAR--IWITTKPVHTSSESGSS 880
            :||.|....|:|       |.....|..|        :...||:..  |:.....||...:..|.
Mouse   826 AAMALSLITFIW-------EHLFYWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKKKSP 883

  Fly   881 NSSSSSSSRSKHSFKSQGLSMKSLKSSGYQDVEASVHSKLKKIGSMFSLKSQKTVTPPPEIGWKL 945
            :.:.:.         ||...:|.|:|:             |.|.:|.::.|.:..:|.....:..
Mouse   884 DFNLTG---------SQSNMLKLLRSA-------------KNISNMSNMNSSRMDSPKRAADFIQ 926

  Fly   946 DKSTQIDVVPT------SD---------VDQELIPEVEPHLPHRHHHHHHHRHHHHHHQPDQEHD 995
            ..|..:|:|..      ||         :..|.:.|::..:.:||.....:......| |...::
Mouse   927 RGSLIVDMVSDKGNLIYSDNRSFQGKDSIFGENMNELQTFVANRHKDSLSNYVFQGQH-PLTLNE 990

  Fly   996 RNPSPPE 1002
            .||:..|
Mouse   991 SNPNTVE 997

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	27..397	CDD:380605	76/443 (17%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	111/442 (25%)
Grin2a	NP_032196.2	PBP1_iGluR_NMDA_NR2	32..387	CDD:380601	88/471 (19%)
		PBP2_iGluR_NMDA_Nr2	403..802	CDD:270436	111/430 (26%)
		NMDAR2_C	839..1464	CDD:463148	32/182 (18%)