Protein Alignment clumsy and Grin1

DIOPT Version :10

• Sequence 1: NP_001036373.1
• Gene: clumsy / 35394
• FlyBaseID: FBgn0026255
• Length: 1002
• Species: Drosophila melanogaster
• Sequence 2: NP_001359487.1
• Gene: Grin1 / 14810
• MGIID: 95819
• Length: 959
• Species: Mus musculus
• Alignment Length: 1029
• Identity: 241/1029 - (23%)
• Similarity: 427/1029 - (41%)
• Gaps: 193/1029 - (18%)

  Fly     8 HFLLIALP-----VLADIDRSQFMVGSIFTSDKDESEIAFRTAVDRAN------ILERNVELVPI 61
            |.|..||.     ..|..|.....:|::.::.|.|.  .||.||::||      .::.|...|
Mouse     5 HLLTFALLFSCSFARAACDPKIVNIGAVLSTRKHEQ--MFREAVNQANKRHGSWKIQLNATSV-- 65

  Fly    62 VVYANTDDSFIMEKMVC-NLISQGVIAIF--GPSTGSSSDIIASICDTLDIPHI-VYDWIPNESI 122
               .:..::..|...|| :|||..|.||.  .|.|.:.......:..|.....| |.......||
Mouse    66 ---THKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSI 127

  Fly   123 -PDREHSTMTLNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKE----LQQLQDILQVGEPISN 182
             .|:......|...|.....|....|:::.:.|....::...|.|    .::|:.:|:..|..|.
Mouse   128 YSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYNWNHIILLVSDDHEGRAAQKRLETLLEERESKSK 192

  Fly   183 PTT-------------------VKQLGPGDDH-RPFLKEIKLSTDNCLILHCAPDNLLKILQQAN 227
            ...                   |.|..||..: ...|.|.:......:||..:.|:...:.:.|.
Mouse   193 KRNYENLDQLSYDNKRGPKAEKVLQFDPGTKNVTALLMEARDLEARVIILSASEDDAATVYRAAA 257

  Fly   228 ELKMLGEYQSVFIPLLDTHSIDFGELSGVEANITTVRLMDPSDFHVKNVVHDWEEREKREGRYFK 292
            .|.|.|   |.::.|:....|....|......|..::|::.
Mouse   258 MLNMTG---SGYVWLVGEREISGNALRYAPDGIIGLQLING------------------------ 295

  Fly   293 VDPNRVKSQMILLNDAVWLFSKGLTELGIFEELTAPDLECRRK----KPWPFGKRIIEFIKARSE 353
                  |::...::|||.:.::.:.||...|.:|.|...|...    |..|..||::  :.::..
Mouse   296 ------KNESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVL--MSSKYA 352

  Fly   354 ETSTGRIDFNENGQRSFFTLRFMELNSDGFLDLATWDPVNGLDVLNDDE-------ESEKRVGQK 411
            :..|||::|||:|.|.|.....|.|.:...:.:..:   ||..|:.:|.       |:||..|.:
Mouse   353 DGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIY---NGTHVIPNDRKIIWPGGETEKPRGYQ 414

  Fly   412 LSNKTFIVSSRLGAPFLTLR----------------EPQEGEILT-------GNSRYE------G 447
            :|.:..||:.. ..||:.::                :|.:..|.|       |:.|:.      |
Mouse   415 MSTRLKIVTIH-QEPFVYVKPTMSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYG 478

  Fly   448 YSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQT----WDGIVRQLIDGNADLGICDLTMTSS 508
            :.:||:.::|:.:||.:|..:..|||:|...:|..:    |:|::.:|:.|.||:.:..||:.:.
Mouse   479 FCVDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNE 543

  Fly   509 RRQAVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPD 573
            |.|.::|:.||...|::||..| ..|.:.|.||:.||...:|:.:|.:...::::|:.|.|.:|
Mouse   544 RAQYIEFSKPFKYQGLTILVKK-EIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSP- 606

  Fly   574 DWENPHPCKEPEEVENIWSIMNTTWLSIGSLMGQGC-DILPKAASTRLVTGMWWFFALMMLNSYT 637
              .........||.|:..::.:..|.|.|.|:..|. :..|::.|.|::..:|..||::::.|||
Mouse   607 --FGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYT 669

  Fly   638 ANLAAFLTNSRQANSINSAEDLAAQS---KIKYGAMAGGSTMGFF-RDSNFSTYQKMWTAMESAS 698
            |||||||...|....|....|...::   |..|..:...|...:| |....||   |:..||..:
Mouse   670 ANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELST---MYRHMEKHN 731

  Fly   699 PSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVERKCDLVQIGGWLDYKSYGIAMPFNSPYRK 763
                .::..|.::.|:..| |:||:.:|..||:...:|||||..|.......:||.|..:||:::
Mouse   732 ----YESAAEAIQAVRDNK-LHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQ 791

  Fly   764 QISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVGGVFLVLGLGLLSAM 828
            .:|.::||..|.|.:.:|.:.|.:       .::.|........|..||:.|||:::..|:::.:
Mouse   792 NVSLSILKSHENGFMEDLDKTWVR-------YQECDSRSNAPATLTFENMAGVFMLVAGGIVAGI 849

  Fly   829 VLGCTEFLWNVKSVAIEEKISLKEAFKSEALFAARIWITTKPVHTSSESGSSNSSSSSSSRSKHS 893
            .|...|..:.....|..:::.|       |..|..:|             ..|.....|.|::..
Mouse   850 FLIFIEIAYKRHKDARRKQMQL-------AFAAVNVW-------------RKNLQDRKSGRAEPD 894

  Fly   894 FKSQGLSMKSLKSSGYQDVEASVHSKLKKI---------GSMFSLKSQK-TVTP 937
            .|         |.:.::.:.:::.|..|:.         |...:|::|| ||.|
Mouse   895 PK---------KKATFRAITSTLASSFKRRRSSKDTSTGGGRGALQNQKDTVLP 939

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	27..397	CDD:380605	85/408 (21%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	114/410 (28%)
Grin1	NP_001359487.1	PBP1_iGluR_NMDA_NR1	25..404	CDD:380602	87/423 (21%)
		PBP2_iGluR_NMDA_Nr1	416..820	CDD:270437	115/423 (27%)
		CaM_bdg_C0	856..884	CDD:402271	6/47 (13%)