DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and Grik5

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	XP_030098003.1	Gene:	Grik5 / 14809	MGIID:	95818	Length:	1003	Species:	Mus musculus

Alignment Length:	902	Identity:	306/902 - (33%)
Similarity:	485/902 - (53%)	Gaps:	98/902 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 YANTDDSFIMEKMVCNLISQGVIAIFGPSTG-SSSDIIASICDTLDIPHIVYDWIPNESIPDREH 127
            |..||       .:|.::.:||:::.|||:. :|:..::.||...:||||.   :..|..|..::
Mouse    76 YETTD-------TMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIK---VGPEETPRLQY 130

  Fly   128 STM-TLNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEPISNPT-TVKQLG 190
            ... :::::|.|..:|..::.|::||.:.|.:::....:.|.:|::::: |..||..| :|:.|.
Mouse   131 LRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVR-GFLISKETLSVRMLD 194

  Fly   191 PGDDHRPFLKEI---KLST----DNCLILHCA-------------PDNL---LKILQQANELKML 232
            ...|..|.||||   |:||    .|..|.|..             |.:|   |..:.||:||.|.
Mouse   195 DSRDPTPLLKEIRDDKVSTIIIDANASISHLVLRLSLNLSSPLGFPRSLPLGLSCVLQASELGMT 259

  Fly   233 GEYQSVFIPLLDTHSIDFGELSGVEANITTVRLMDPS-DFH---VKNVVHDWEEREKREGRYFKV 293
            ..:....:..:|...:....:....:||....:.:.| .|:   |:::...|  ||..|...:
Mouse   260 SAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSW--RENCEASTY-- 320

  Fly   294 DPNRVKSQMILLNDAVWLFSKGLTELGIFEELTAPDLECRRKKPWPFGKRIIEFIKARSEETSTG 358
             |....|..::. |||.:....:.||...:|:....|.|.....||.|..::.:::....:..||
Mouse   321 -PGPALSAALMF-DAVHVVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGLTG 383

  Fly   359 RIDFNENGQRSFFTLRFMELNSDGFLDLATWDP-------VNGLDVLNDDEESEKRVGQKLSNKT 416
            |::||..|||:.:|||.:|.:..|..::..|..       ...||:         .:.|.|:|||
Mouse   384 RVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLDI---------NLSQTLANKT 439

  Fly   417 FIVSSRLGAPFLTLREPQEGEILTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVT 481
            .:|::.|..|:: :|.| ..:.|:||.|:||:.:|::.|:|::|.|::..|:..||.||| .:..
Mouse   440 LVVTTILENPYV-MRRP-NFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGA-PEPN 501

  Fly   482 QTWDGIVRQLID-GNADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPF 545
            .:|.|:|.:||: ..|||.:...|:|:.|.:.:||:.||||||||||:..........||||.||
Mouse   502 GSWTGMVGELINRQKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPF 566

  Fly   546 SLDVWIYMGSAYLFISLLLFALARMAPDDWENPHPC--KEPEEVENIWSIMNTTWLSIGSLMGQG 608
            |..||::|..|||.:|.:||..||::|.:|.|||||  ..|..:||.:::.|:.|..:|..|.||
Mouse   567 SPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQG 631

  Fly   609 CDILPKAASTRLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMAGG 673
            .:|:|:|.|||.|:|:||.|.|::::|||||||||||..|....:.||:|||.|:.|:||.:..|
Mouse   632 SEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAG 696

  Fly   674 STMGFFRDSNFSTYQKMWTAMESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVERKCD 738
            |||.||::|.:.|||:||..|:|..||||.|:.:||:.||...:  ||||:|||..||:....|:
Mouse   697 STMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSR--YAFLLESTMNEYHRRLNCN 759

  Fly   739 LVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGG 803
            |.||||.||.|.|||.||..||:|.:|:.|:|:|.|..:|..||||||:    ||.|.|  |:..
Mouse   760 LTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWE----GGRCPK--EEDH 818

  Fly   804 DTPELGLENVGGVFLVLGLGLLSAMVLGCTEFLWNVKSVAIEEKISLKEAFKSEALFAARIWITT 868
            ....||:||:||:|:||..||:.|:.:...||:|:.:..|..|::|:.:....|...|.
Mouse   819 RAKGLGMENIGGIFVVLICGLIIAVFVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAV------ 877

  Fly   869 KPVHTSSESGSSNSSSSSSSRSKHSFKSQGLSMKSLKSSGYQDVEASVHSKLKKIGS 925
                          |...:|||:...:..|.|...|.....:::..| :.||...|:
Mouse   878 --------------SCRKTSRSRRRRRPGGPSRALLSLRAVREMRLS-NGKLYSAGA 919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	90/368 (24%)
		ANF_receptor	39..379	CDD:279440	88/344 (26%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	175/375 (47%)
		Lig_chan	548..812	CDD:278489	128/265 (48%)
Grik5	XP_030098003.1	PBP1_iGluR_Kainate_KA1_2	23..424	CDD:380616	90/364 (25%)
Grik5	XP_030098003.1	Periplasmic_Binding_Protein_Type_2	437..808	CDD:419667	175/375 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846285
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.660